DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and znf740a

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_005172837.1	Gene:	znf740a / 571608	ZFINID:	ZDB-GENE-030131-5064	Length:	543	Species:	Danio rerio

Alignment Length:	639	Identity:	165/639 - (25%)
Similarity:	248/639 - (38%)	Gaps:	171/639 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEI 78
            |:...:|:.||        |:::.:|     .||...:..|   :.||:     |::..::....
Zfish    30 LMQASSIAAPK--------KMMSPLG-----PASAHGSGQR---DMQER-----GTQGHMVLPTS 73

  Fly    79 LGTPKTEKRGATKSTAPAASTVKILNEKK-TPSATVTAVETTKIKTSPSKRKKMEHYVLQAVKSE 142
            :..|....|.....|||     ::|:||: .||..:...:.|:...:|||.::.:....:||..|
Zfish    74 MTCPPLLLRKEADFTAP-----RLLDEKEMRPSEDMQLKKKTRKSGTPSKVREQDGPAGKAVVDE 133

  Fly   143 NTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSGKG 207
            |                                                               |
Zfish   134 N---------------------------------------------------------------G 135

  Fly   208 NSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVMEKK 272
            |...:|:::  ..:|..||..||               |||||::..::.          ..||.
Zfish   136 NCPLSKVQK--NFICDHCYGAFR---------------SGYHLKRHILIH----------TGEKP 173

  Fly   273 DICFCCS---------ESYDTFHLG--HINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNA 326
            ..|..|.         |.:...|.|  ...|..|...|..:...||| .:||:....:.|::|:.
Zfish   174 FACAVCDMRFIQRYHLERHSLTHTGVKPYACSMCDMRFFQRYHLERH-SLTHTGVKPYACTMCDM 237

  Fly   327 NLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYR 391
            .......|..|...| :..|||||.:|.:.|.:.|||:||    |.:.......:|.:||..|::
Zfish   238 RFFQRYHLQRHSLIH-TGVKPYACSMCDRRFFQRYHLQRH----SLTHTGVKPYACSICDMRFFQ 297

  Fly   392 LDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVAL 456
                |.||::|..|....|| :.|..|...|:....|..|..||||.||:.|.:||.:|.....|
Zfish   298 ----RYHLQRHSLTHTGVKP-FACTMCDMRFFQRYHLQRHSITHTGVKPYACSMCDMRFFHRYHL 357

  Fly   457 KKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTH-- 519
            ::|...|||.|||:||:|:..|..:..|.||...|||.:|:.|..|...|.|...|:.||.||
Zfish   358 QRHSLTHTGVKPYACTMCDMRFFQRYHLQRHSLTHTGVKPYACSMCDMRFFQRYHLQRHSLTHTG 422

  Fly   520 IRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGK--HS---P 579
            ::|:.|..||.:|.....||||..||:..|  .|:|..|...|    :.:.|::..|  ||   |
Zfish   423 VKPYACSMCDMRFFQRYHLERHSLTHTGEK--PFACDMCDMRF----IQRYHLERHKRVHSGEKP 481

  Fly   580 KQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHP 633
            .|                |..|.:||..:|.|.||.|.   |....:..||..|
Zfish   482 YQ----------------CERCQQNFSRTDRLLRHRRL---CQGRGVTKVEAQP 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	71/204 (35%)
		C2H2 Zn finger	321..341	CDD:275368	4/19 (21%)
		zf-C2H2	348..368	CDD:278523	10/19 (53%)
		C2H2 Zn finger	350..368	CDD:275368	8/17 (47%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-H2C2_2	428..451	CDD:290200	11/22 (50%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	11/23 (48%)
		COG5048	<467..620	CDD:227381	54/159 (34%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	10/23 (43%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	8/19 (42%)
		C2H2 Zn finger	555..572	CDD:275368	3/16 (19%)
		C2H2 Zn finger	598..615	CDD:275371	7/16 (44%)
znf740a	XP_005172837.1	COG5048	138..503	CDD:227381	128/424 (30%)
		C2H2 Zn finger	148..168	CDD:275368	10/34 (29%)
		C2H2 Zn finger	176..196	CDD:275368	3/19 (16%)
		C2H2 Zn finger	204..224	CDD:275368	6/20 (30%)
		C2H2 Zn finger	232..252	CDD:275368	4/19 (21%)
		C2H2 Zn finger	260..280	CDD:275368	9/23 (39%)
		C2H2 Zn finger	288..308	CDD:275368	8/23 (35%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	5/23 (22%)
		C2H2 Zn finger	484..503	CDD:275368	8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100