DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and CG8301

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	126/554 - (22%)
Similarity:	219/554 - (39%)	Gaps:	121/554 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 KSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGEDSS 204
            ::|.||..|||:..|:.::|    .:|..|:....::.:..:|   .|::|:..:..||:.|:..
  Fly   117 ETETTKPTTTVSAETQPNNT----ASDPIEIFVDAVDIDEAEE---EEEEEEQQQQYDEEVEEPI 174

  Fly   205 GKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVVM 269
             ...|:..::  .:.:.|                 :||             |:..|..:...:::
  Fly   175 -TDESAPPQL--TISYAC-----------------KFC-------------LRPQENYQLQQLLL 206

  Fly   270 EKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALL 334
            |..:......:.|        |||:|...|:...|...|:..:|.| ....|.:|.........|
  Fly   207 EHINASHDPEQPY--------NCPECEARFQDAASRTVHLKSSHVE-KQHACGVCGKKYGDRHNL 262

  Fly   335 ALHEEQHKSRGKPYACKICGKDF-TR---SYHLKRHQKYSSCSSNETDTMSCK--VCDRVFYRLD 393
            ..|.|::.|. ..:.|.:|.|.| ||   :||:|.|        |......|:  .|:|:|....
  Fly   263 RHHVEKYHSE-TDFECALCEKRFYTRKSLNYHMKWH--------NPDRQFKCRHSGCERLFISQR 318

  Fly   394 NLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHI-RTHTGEKPFDCDLCDKKFSA----- 452
            :|..|...|.||. .:|.|: |..|...|..|.||..|| |.|.||||:.|..|.:.|::
  Fly   319 HLMCHEATHSGTS-SRKSEH-CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKR 381

  Fly   453 LVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERP--------------------- 496
            :..|::||...|..:...|.:|.|.|:.:..|..||.....:||
  Fly   382 IHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYS 446

  Fly   497 --HKCDECGKSFIQATQLRTHSKTHI---RPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCA 556
              .:|..|.:.|...:.|..|:..|.   ||..|..|.::||..:.::.|:|||.:.|..|  |.
  Fly   447 GLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNV--CD 509

  Fly   557 ECKRNFRTPALLKEHMDEGKHSPKQQRSSM-------RSAVKIMERT-------DCAICDKNFDS 607
            .|.:.|....:|.:|....:...|..:.::       ..::::.:||       .|.:|.:.|.:
  Fly   510 VCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVT 574

  Fly   608 SDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDI 641
            ...|:.|::..|...       :||.:.:...|:
  Fly   575 HIKLKTHMQKAHAAS-------QPHSADQPLDDL 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	65/239 (27%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		zf-C2H2	348..368	CDD:278523	10/23 (43%)
		C2H2 Zn finger	350..368	CDD:275368	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	6/21 (29%)
		C2H2 Zn finger	415..435	CDD:275368	9/20 (45%)
		zf-H2C2_2	428..451	CDD:290200	11/23 (48%)
		C2H2 Zn finger	443..463	CDD:275368	6/24 (25%)
		zf-H2C2_2	455..479	CDD:290200	7/23 (30%)
		COG5048	<467..620	CDD:227381	40/192 (21%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	8/46 (17%)
		C2H2 Zn finger	499..519	CDD:275368	5/19 (26%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	4/16 (25%)
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	87/331 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	5/19 (26%)
		C2H2 Zn finger	537..557	CDD:275368	1/19 (5%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930