DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and CTCF

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	209/944 - (22%)
Similarity:	327/944 - (34%)	Gaps:	257/944 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KDKRPATRMKLLNDV-----GAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEE------ 77
            ||:.|......||:.     |..::...:|........:...::.|:.||....:...|
  Fly     7 KDEDPEDLQTFLNNFHKEIEGNSDEKVVNTILEAISAEAIDLDENGAEAGGSKPMEEAEADLDHA 71

  Fly    78 -----------------------ILGTPKTE-------KRGATK---------STA--------P 95
                                   |..|||.:       |:.|.|         |||        |
  Fly    72 EEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRSVVSTATNKSINLRP 136

  Fly    96 AASTVKILNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQAV----------------KSENT 144
            |.||.|....|..|.....:|...:...:.:|:..|.......|                |.|..
  Fly   137 AKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPEPM 201

  Fly   145 KADTTVTVVTEEDDTIDFI--LAD---DEEVVPGRIENNNGQEIVVTE-DDEDLGEDGDEDGEDS 203
            ..:..:..:.:|.|....:  |:|   ||..|..........|..|.| :|....||.:.|
  Fly   202 DLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENAD---- 262

  Fly   204 SGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDAVV 268
                                            ||.::|             :|.|.|...|.|
  Fly   263 --------------------------------KKDVDF-------------VLSNKEVKLKTA-- 280

  Fly   269 MEKKDICFCCSESYDTFHLGH-INCPDCPKSFKTQTSYERHIFITHSEFSD----FPCSICNANL 328
                     .|.|.::...|| .:||.||     .|:.::.:...||...|    |.||||..:.
  Fly   281 ---------SSTSQNSNASGHKYSCPHCP-----YTASKKFLITRHSRSHDVEPSFKCSICERSF 331

  Fly   329 RSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLD 393
            ||...|..|...|.. .||:.||:|...||.|..|.||.:|   ...:.....|..|......|.
  Fly   332 RSNVGLQNHINTHMG-NKPHKCKLCESAFTTSGELVRHTRY---KHTKEKPHKCTECTYASVELT 392

  Fly   394 NLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKK 458
            .||.|:..|.|    ::| |.|..|......:..|..|:..|||||.:.||:|..:|:...:||.
  Fly   393 KLRRHMTCHTG----ERP-YQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKA 452

  Fly   459 HRRYHT-GEKP-YSCTVCNQAFAVKEVLNRHMKR-HTGERPHKCDECGKSFIQATQLRTHSKTH- 519
            |:..|: .:|| :.|..|......|..|..|:|. ||.:.|..|..||:......|.:.|.|:|
  Fly   453 HKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHE 517

  Fly   520 -IRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMD---EGKHSPK 580
             .:.:.|:.|.....|::.|..|:..|...|  .|.|.:|.:.||...||:.||:   ..::.|.
  Fly   518 GEKCYSCKLCSYASVTQRHLASHMLIHLDEK--PFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPP 580

  Fly   581 QQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEE 645
            :.|..:..         |..|.:.|.....|.||:.| |    ||  .......:|..|
  Fly   581 EPREKLHK---------CPSCPREFTHKGNLMRHMET-H----DD--SANAREKRRRLK------ 623

  Fly   646 VVPVALNTSAGSLISSQTDGNGV-VVREFLVDEGDGAAQTITLEN-ETYTILPLDGA-IEGEQLT 707
                     .|..:..|.||..: ::::..||......:....:| |:|.:..::.. .|.|...
  Fly   624 ---------LGRNVRLQKDGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDAD 679

  Fly   708 DEA-GVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADN-------------LEESCSEDDFS- 757
            |:. .:..:..::..:.:|::..:|.: ||||....:..|             ::|.....||:
  Fly   680 DDVETIVSDPIRQRIKPAPIIINKQAR-LAASEKQPMIINQRLRSQRGTKTFHIKEEPDNSDFTV 743

  Fly   758 ------GEILTEEDIKLKENVGKLIDMLV--DPPILKKYGWPNAPEETVLCKV-IENC-----GH 808
                  ||::..|              ||  |..:|.|:      |.:...|: .:||     ..
  Fly   744 EWQGDDGEVMVVE--------------LVNGDEEVLVKH------EPSANSKISAKNCFGFEDDD 788

  Fly   809 DLTKGGENYAELDYGSRMREYCKLLFTVVIHNDS 842
            |..:.|:...|:|..|  :|:.:|:  .:|..||
  Fly   789 DYEEYGDGENEVDGAS--QEFLQLM--DMIEQDS 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	5/20 (25%)
		COG5048	<312..517	CDD:227381	68/211 (32%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		zf-C2H2	348..368	CDD:278523	9/19 (47%)
		C2H2 Zn finger	350..368	CDD:275368	9/17 (53%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		zf-H2C2_2	428..451	CDD:290200	10/22 (45%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		zf-H2C2_2	455..479	CDD:290200	8/25 (32%)
		COG5048	<467..620	CDD:227381	43/159 (27%)
		C2H2 Zn finger	471..491	CDD:275368	6/20 (30%)
		zf-H2C2_2	484..508	CDD:290200	9/24 (38%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..572	CDD:275368	6/16 (38%)
		C2H2 Zn finger	598..615	CDD:275371	5/16 (31%)
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	16/89 (18%)
		C2H2 Zn finger	296..316	CDD:275368	7/24 (29%)
		COG5048	321..>621	CDD:227381	95/326 (29%)
		zf-C2H2	322..344	CDD:278523	9/21 (43%)
		C2H2 Zn finger	324..344	CDD:275368	8/19 (42%)
		zf-H2C2_2	337..361	CDD:290200	9/24 (38%)
		C2H2 Zn finger	352..373	CDD:275368	10/23 (43%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	9/25 (36%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	8/26 (31%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	7/31 (23%)
		C2H2 Zn finger	589..609	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100