DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and D19B

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	150/730 - (20%)
Similarity:	238/730 - (32%)	Gaps:	257/730 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DTTVTVVT---EEDDTIDF---------ILADDEEVVP--------------------GRIENNN 179
            ||:..|..   ||:|.:.|         |:.::|:|..                    ||:..::
  Fly   100 DTSAAVADLPGEEEDNVHFDPLLNSKIEIIENEEDVFKMLESVEKEVEEVEMEMEQPFGRVSQDD 164

  Fly   180 GQEIVVTEDDEDLGED----GDED-------------GEDSSGKGNSSQTKIKEIVE-------- 219
            ..|   :.:|.||..|    .|:|             |..:.||..|:..:.:|..|
  Fly   165 SFE---SGNDNDLDADFQISSDDDIPLAQRSRRGATRGSKAKGKPKSAAKRQEEESEESEETSSS 226

  Fly   220 -----------------------------HVCGKCYKTFRRVQSLKKH----LEF-CRYDSGYHL 250
                                         |:|.:.:|...|.:...||    |.| |..:|   .
  Fly   227 DDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVES---C 288

  Fly   251 RKADMLKNLEKIEKDAVVMEKKDICFC----CSESYD-----TFHLGHINCPDCPKSFKTQTSYE 306
            ||.....|..::..:....|...:..|    |::|:.     :||:..::..|.|:
  Fly   289 RKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQ--------- 344

  Fly   307 RHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSY----HLKRHQ 367
                      .||||:.|....|....|..|..:|.....|:||:||||.|..:.    ||.||.
  Fly   345 ----------RDFPCTECEKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHA 399

  Fly   368 KYSS-----CSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLST 427
            ...:     |...:|                 .|....:|:.|. .|:.:|.|..|.:..::...
  Fly   400 GIKNHVCPYCGVGKT-----------------TRQEWNKHILTH-TKEKKYECRQCDHASHNKQA 446

  Fly   428 LNIHIR-THTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRH 491
            |..|:: .|...|.|.|..|.|.|....|.|.|.|.|||||...|.:|.:.|..::.|.:|:|.|
  Fly   447 LANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTH 511

  Fly   492 -------------------TG-------------------------------------------- 493
                               :|
  Fly   512 EKRDLPKTQGTNALMGDGASGSSTIAKPSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVN 576

  Fly   494 ----ERPHKCDECGKSFIQATQLRTHSKT---HIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRP 551
                |..|.|.:|||.|...:.::.|.|.   .::.|.|..|.::|..::.|..|...|:..|
  Fly   577 FTKKEGQHICPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEK-- 639

  Fly   552 VFSCAECKRNFRTPALLKEHM--------DEGK-HSPKQQRSSMRSAVKIMERTDCAICDKNFDS 607
            .:.|..|.::||...:||.||        ..|| ..|...::...:|||..:       .|||:.
  Fly   640 PYECKVCGKHFRQEQVLKTHMKVHDKPPRPPGKPKEPAGPKAESSTAVKRQQ-------PKNFEQ 697

  Fly   608 -SDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDIESEEVVPVAL----------NTSAGSLISS 661
             .|..........|.   ..:.:|.:.:|| |.:.|..::...|.          ||..| ..:.
  Fly   698 YQDPAAERAAATAEL---LAYQIEENEAKR-KAEAELRKIQEAAFEQLNKLQKQSNTYDG-FYAQ 757

  Fly   662 QTDGNGVVVREFLVD 676
            :.:..|..|....:|
  Fly   758 KAEAEGTSVDALKLD 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	2/20 (10%)
		COG5048	<312..517	CDD:227381	64/281 (23%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		zf-C2H2	348..368	CDD:278523	11/23 (48%)
		C2H2 Zn finger	350..368	CDD:275368	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	1/19 (5%)
		C2H2 Zn finger	415..435	CDD:275368	4/20 (20%)
		zf-H2C2_2	428..451	CDD:290200	8/23 (35%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..479	CDD:290200	11/23 (48%)
		COG5048	<467..620	CDD:227381	44/232 (19%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	12/90 (13%)
		C2H2 Zn finger	499..519	CDD:275368	7/22 (32%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..572	CDD:275368	6/16 (38%)
		C2H2 Zn finger	598..615	CDD:275371	4/17 (24%)
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..335	CDD:275368	11/54 (20%)
		C2H2 Zn finger	318..338	CDD:275368	4/19 (21%)
		COG5048	<347..512	CDD:227381	53/182 (29%)
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..426	CDD:275368	4/36 (11%)
		C2H2 Zn finger	434..455	CDD:275368	4/20 (20%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	586..607	CDD:275368	7/20 (35%)
		C2H2 Zn finger	615..635	CDD:275368	5/19 (26%)
		zf-H2C2_2	627..652	CDD:290200	7/26 (27%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930