DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and Oaz

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	1119	Identity:	210/1119 - (18%)
Similarity:	336/1119 - (30%)	Gaps:	385/1119 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASKEGKE----KKGKLLGVEN--ISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNK 59
            ||..|:.|.    |.|:....||  :..||:       :||:.....||:|..         ...
  Fly     1 MSRRKQAKPRACLKLGEKEDEENTGLLEPKE-------ELLSGDEDNEDNEGE---------DED 49

  Fly    60 QEKRGSVA-----GSRIKILNEEI--LGTPKTEKRGATKSTAPAASTVKILNEKKTPSATVTAVE 117
            :|....||     |.|.:::..|.  ...|..::..|..:.|......:...|.:.|...|.|.:
  Fly    50 EEVADEVAPEGGGGERPQLVPNESQQQSWPTADEPAAPAAVAKEEEAEEGSEELQHPRDEVVASD 114

  Fly   118 TTKIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEE------------- 169
            .........|....|...:.|.:.|:.:.|..:..::.::|      .||||
  Fly   115 AAANANGHCKSSGHEEDAVDAEEPEDLELDDELLSLSGDED------YDDEELQSLDSFYSDMYS 173

  Fly   170 ----------VVPGRIENNN----------GQEIVVTEDDEDLGEDGDE---------------- 198
                      :..|.:..|:          |||...||...:.|.||::
  Fly   174 THTSSSYSPSISDGTMTPNSHHLIGAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHH 238

  Fly   199 ----------------------DGEDSSGKGNSSQTKIKEIV----------EHVCGKCYKTFRR 231
                                  .|..:.|....:.:|..::.          .:.|..|.|||.|
  Fly   239 HYHHQQALKIANKLRKINKEAKMGATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPR 303

  Fly   232 -------VQSLKKHLEF-CRYDSGY--HLRKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFH 286
                   |||..:||.| |.|.|..  |.|..|..|.|...|:
  Fly   304 LGYLKHHVQSHAEHLPFKCEYCSKLFKHKRSRDRHKKLHTNER---------------------- 346

  Fly   287 LGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSR------- 344
              :..||.|..:|......:.|: .||.....|.||:||....:.|.|..|.::||..
  Fly   347 --NYKCPHCEAAFSRSDHLKIHM-KTHDIQKPFQCSMCNRGYNTAAALTSHMQKHKKNAAILAAG 408

  Fly   345 GKP---------------------------YACKICG------KDF---TRSYHLKRHQKYSSCS 373
            |.|                           ||..:..      .||   :||.|:..    ::.:
  Fly   409 GNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRMDFPKRSRSNHVGG----TTTT 469

  Fly   374 SNETDTMSCKVCDRV--FYRLDNLRSHLK---QHLGTQVVKKP-------EYMCHTCKNCFYSLS 426
            :..|..:.|..|.:|  |..|:.|.:||:   :...||.||.|       :..|..|...|.:::
  Fly   470 ATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGEGFQLSCEYCTMKFGNIA 534

  Fly   427 TLNIHIR-THTGE-------------------------------KP------------------- 440
            .|..|:| ||...                               ||
  Fly   535 GLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDLGSPERESRPAEDDLPTD 599

  Fly   441 ----------------------------FDCDLCDKKFSALVALKKHRRYHTGE-KPYSCTVCNQ 476
                                        |.|:.|:.......:.:.|.:.|..| ....|..|..
  Fly   600 LSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHLKSHIAEGMQLVCPHCGM 664

  Fly   477 AFAVKEVLNRHMKRH---TGERPHKCDECGKSFIQATQLRTH--SKTHIRPFPCEQCDEKFKTEK 536
            :...:....||:..|   ||...:....|||||.::..|:.|  |:..:....|..|.|..::..
  Fly   665 SLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHVLTLLKCSLCSELCESRM 729

  Fly   537 QLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDE----GKH-----------SPKQ---QR 583
            .::.|:......:..:..|:.|...||:.|....|:..    |.|           :|.|   .|
  Fly   730 AMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRHQLGGHPTLGATSSAPTNPLQCMFCR 794

  Fly   584 SSMRSAVKI-------MERTDCAICDKNFDSSDTLRRHIRTVHECDPDDIFGVEPHPSKRAKKDI 641
            :...|.:::       ..:..|..|.:.|.....|.||:::.|.       ||:       .|:.
  Fly   795 AVCSSELEMHFHLAAHARQFRCPSCPETFHVEFLLDRHMQSQHG-------GVK-------DKEA 845

  Fly   642 ESEEVVPVALNT-----SAGSLISSQTDGNGVVVREFLVDEG--DGAAQTITLENETYTILPLDG 699
            .|..:..:.:|.     :|.:..::.|:.|..::...:..:|  .||:               .|
  Fly   846 NSPNMGSLYVNALLPPLAAAAAAAAATNNNSSIIDYNVAFKGLFGGAS---------------GG 895

  Fly   700 AIEGEQLTDEAGVKPEAKK--EEAQVSPVVKKEQRKSLAASLAAAIADNLEESCSEDDFSGEILT 762
            |..|.......|..|.|.|  ...||.....|.|     .|...|:...|.:....:.::.:..:
  Fly   896 AGSGGGGAQSGGAPPSANKFYSPLQVDTNALKAQ-----TSPHPALMYGLSQRYLMEMYAAKSTS 955

  Fly   763 EEDIKLKENVGK----LIDMLVDPPILKKYGWPNAPEETVLCKVIENCGHDLTKGGENYA----- 818
            ...   .|.||.    .......||.      |||...|..|.:.|.  .||....|.::
  Fly   956 PSG---NEGVGNSQPPAPQATAPPPP------PNASTATFSCGMCER--QDLRSEAELHSHRKLA 1009

  Fly   819 -ELDYGSRMR-EYC 830
             .|..|..:| .||
  Fly  1010 HNLKTGVSLRCAYC 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	5/20 (25%)
		COG5048	<312..517	CDD:227381	65/344 (19%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		zf-C2H2	348..368	CDD:278523	7/28 (25%)
		C2H2 Zn finger	350..368	CDD:275368	5/26 (19%)
		C2H2 Zn finger	382..402	CDD:275368	8/24 (33%)
		C2H2 Zn finger	415..435	CDD:275368	6/20 (30%)
		zf-H2C2_2	428..451	CDD:290200	10/101 (10%)
		C2H2 Zn finger	443..463	CDD:275368	3/19 (16%)
		zf-H2C2_2	455..479	CDD:290200	5/24 (21%)
		COG5048	<467..620	CDD:227381	37/182 (20%)
		C2H2 Zn finger	471..491	CDD:275368	4/19 (21%)
		zf-H2C2_2	484..508	CDD:290200	10/26 (38%)
		C2H2 Zn finger	499..519	CDD:275368	8/21 (38%)
		C2H2 Zn finger	525..545	CDD:275368	4/19 (21%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	598..615	CDD:275371	5/16 (31%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	8/48 (17%)
		COG5048	336..769	CDD:227381	85/461 (18%)
		zf-C2H2	348..370	CDD:278523	5/22 (23%)
		C2H2 Zn finger	350..370	CDD:275368	5/20 (25%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	630..650	CDD:275368	3/19 (16%)
		C2H2 Zn finger	659..679	CDD:275368	4/19 (21%)
		C2H2 Zn finger	689..707	CDD:275368	6/17 (35%)
		C2H2 Zn finger	1020..1041	CDD:275368	2/4 (50%)
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930