DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and Clamp

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001014498.1	Gene:	Clamp / 35445	FlyBaseID:	FBgn0032979	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	130/607 - (21%)
Similarity:	208/607 - (34%)	Gaps:	176/607 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GKLLGVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNE 76
            |.:|....|...|.::..|.....|..|...:.....||..::|....|    .|.|....::|
  Fly    28 GTILKQPKIEGQKTEQQPTFYYTTNGNGGTVNLAQLATTDDNKTCYIAQ----PVGGYNYALVN- 87

  Fly    77 EILGTPKTEKRGATKSTAPAASTVKILNEKKTPSA-TVTAVE------------------TTKIK 122
               |.|..:......:|..|...::|:|:.|..:| |::.:.                  ..::.
  Fly    88 ---GMPLNQGAALGIATVDAQGRIQIVNQNKPIAANTISNISFKCDVCSDMFPHLALLNAHKRMH 149

  Fly   123 TSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTE 187
            |...::::.:|         |.:|                                .|..|.|
  Fly   150 TDGEQQQQQQH---------NAQA--------------------------------GGDSIAV-- 171

  Fly   188 DDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRK 252
                :...|....::..|.|...|.:|                 |.|
  Fly   172 ----VSAQGLVQAQNIIGNGQMGQIQI-----------------VSS------------------ 197

  Fly   253 ADMLKNLEKIEKDAVVME----KKDICFCCSES--YDTFHLG--HINCPDCPKSFKTQTSYERHI 309
                ..||.:::..:..:    |...|..|..|  ..:...|  .:.|..|.::.:| ...::.:
  Fly   198 ----DTLEPVQQSVMQQQQHESKASKCINCGSSMLQQSKRKGPKQVRCESCMQAEQT-AQQQQQL 257

  Fly   310 FITHSEFSDFPCSICNANLRSEALL---------------------ALHEEQHKSRGKPYACKIC 353
            |:........|..|.:...:::|.|                     ..|..:.::..:...|:.|
  Fly   258 FVAQDGQMAHPVQIISTTPQAQAQLQQIVAAQTGGTTPKREASSGSGHHPVKKRNSQQMTKCQKC 322

  Fly   354 -------------------GKDFTRSYHLKRHQKYSSCSS--NETDTMSCKVCDRVFYRLDNLRS 397
                               |....:|..:|     :.|.|  |.:...||.:|..:|.|..:|.|
  Fly   323 NGSGVVLVGQHSHASHSGVGGSVKQSVTVK-----TECLSCRNPSKPFSCNICGGLFSRYSSLWS 382

  Fly   398 HLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRY 462
            |.|.|.|     :..|.|..|...|.....|..|.|.||||||:.|..|..:||....||.|.|.
  Fly   383 HKKLHSG-----EKNYKCSICGLAFAKAVYLKNHARIHTGEKPYKCQTCGMQFSQSPHLKNHERT 442

  Fly   463 HTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPC 525
            |:||:||.|.||::.||....|..|.:.||||:|:||:.||.:|.||..|:.|:|.|.  :|:.|
  Fly   443 HSGERPYVCGVCDKGFARHATLWNHRRIHTGEKPYKCEICGSAFSQAAHLKNHAKVHSGEKPYKC 507

  Fly   526 EQCDEKFKTEKQLERHVKTHSR 547
            |.|...|.....|:||...|.:
  Fly   508 EICSAAFADRFALKRHRGIHQK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	4/20 (20%)
		COG5048	<312..517	CDD:227381	71/246 (29%)
		C2H2 Zn finger	321..341	CDD:275368	4/40 (10%)
		zf-C2H2	348..368	CDD:278523	5/38 (13%)
		C2H2 Zn finger	350..368	CDD:275368	5/36 (14%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	11/22 (50%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		zf-H2C2_2	455..479	CDD:290200	12/23 (52%)
		COG5048	<467..620	CDD:227381	34/83 (41%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	12/23 (52%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368
		C2H2 Zn finger	598..615	CDD:275371
Clamp	NP_001014498.1	COG5048	<359..498	CDD:227381	59/143 (41%)
		C2H2 Zn finger	367..387	CDD:275368	8/19 (42%)
		zf-H2C2_2	379..403	CDD:290200	9/28 (32%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		zf-H2C2_2	407..432	CDD:290200	12/24 (50%)
		C2H2 Zn finger	423..443	CDD:275368	8/19 (42%)
		zf-H2C2_2	435..460	CDD:290200	13/24 (54%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	464..488	CDD:290200	12/23 (52%)
		COG5048	475..>529	CDD:227381	21/53 (40%)
		C2H2 Zn finger	479..499	CDD:275368	9/19 (47%)
		zf-H2C2_2	491..515	CDD:290200	8/23 (35%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910