DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and Kr-h1

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	179/727 - (24%)
Similarity:	263/727 - (36%)	Gaps:	229/727 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 TEKRGATKSTAPAASTVK---------ILNEKKTPSATVTAVETTKIKTSPSK---RKKMEHYVL 136
            ||.:..|||.||....:|         :|:..|:|:..|.      :|.||:|   ..||.:|
  Fly     2 TESKNDTKSWAPKQIWIKDVLKKSGTELLDISKSPAKAVA------VKKSPAKDSATTKMVYY-- 58

  Fly   137 QAVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGE 201
                |.|     .:.:.||:.....|.|    :|.|         .:..|.....||.      .
  Fly    59 ----SAN-----QLLIKTEQSSQAQFCL----QVPP---------PLTATTTSVGLGV------P 95

  Fly   202 DSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKIEKDA 266
            .|.|:           .||     ::..:..|..:..|:               |::..:.|:..
  Fly    96 PSGGQ-----------QEH-----FELLQTPQQRQMQLQ---------------LQDQHQQEQQQ 129

  Fly   267 VVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSE 331
            .|            ||......|          :.|...::|..||::..:..|.:   ..:::|
  Fly   130 FV------------SYQLAIQQH----------QKQQQQQQHESITNAAPTAAPSA---QRIKTE 169

  Fly   332 ------ALLALHEEQHK-SRGKP-YACKICGKDF----TRSYHLKRHQKYSSCSSN--------- 375
                  |..|:..:..| |..|| :.|..||..|    ..:.|.|.|.|....|.|
  Fly   170 PVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKSAHTSHTKSHSKNQDLSLNGASGAGVAA 234

  Fly   376 ETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKP-------------EYMCHTCKNCFYSLST 427
            ...|.:.::.|              ..|...:.|.|             .|.|:.|:..|...:.
  Fly   235 PVSTAAIELND--------------AGLPVGIPKSPTIKPLANVAAGADPYQCNVCQKTFAVPAR 285

  Fly   428 LNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHT 492
            |..|.||||||:||:|:.|.|.||....|:.|||.||.|:||.|.||.:||.....|:|||:.||
  Fly   286 LIRHYRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAFEHSGKLHRHMRIHT 350

  Fly   493 GERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQ--CDEKFKTEKQLERHVKTHSRTKRPVF 553
            |||||||..|.|:|||:.||..|.:||.  :|:.|.:  |.:.|...|||:.|.:||:..|  .:
  Fly   351 GERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLKVHSRTHTGEK--PY 413

  Fly   554 SCAECKRNFRTPALLKEHMDE--GKHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIR 616
            .|..|.|:|....:||.|..:  |....|                 |.|||:.|.:...:..||:
  Fly   414 HCDICFRDFGYNHVLKLHRVQHYGSKCYK-----------------CTICDETFKNKKEMEAHIK 461

  Fly   617 TVHECDPDDIFGVEPHPSKRAKKDIESE-EVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDG 680
            ......|||                |:| .....|.:|||||                  ..|..
  Fly   462 GHANEVPDD----------------EAEAAAASAAASTSAGS------------------SAGSP 492

  Fly   681 AAQTITLENETYTILPLDGAIEGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIAD 745
            :.|.::..:|:....|             ....|..||......|.|.    |::||:|:...:.
  Fly   493 SLQGVSSNSESSNHSP-------------PSSPPATKKPRQARQPRVS----KTVAATLSIPTSS 540

  Fly   746 NLEESCSEDDFS 757
            .|..|.....:|
  Fly   541 PLSPSSLSSTYS 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	3/20 (15%)
		COG5048	<312..517	CDD:227381	78/238 (33%)
		C2H2 Zn finger	321..341	CDD:275368	3/25 (12%)
		zf-C2H2	348..368	CDD:278523	7/23 (30%)
		C2H2 Zn finger	350..368	CDD:275368	7/21 (33%)
		C2H2 Zn finger	382..402	CDD:275368	1/19 (5%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	13/22 (59%)
		C2H2 Zn finger	443..463	CDD:275368	9/19 (47%)
		zf-H2C2_2	455..479	CDD:290200	13/23 (57%)
		COG5048	<467..620	CDD:227381	57/158 (36%)
		C2H2 Zn finger	471..491	CDD:275368	9/19 (47%)
		zf-H2C2_2	484..508	CDD:290200	16/23 (70%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	525..545	CDD:275368	7/21 (33%)
		C2H2 Zn finger	555..572	CDD:275368	6/16 (38%)
		C2H2 Zn finger	598..615	CDD:275371	5/16 (31%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	69/151 (46%)
		zf-C2H2	271..293	CDD:278523	7/21 (33%)
		C2H2 Zn finger	273..293	CDD:275368	6/19 (32%)
		zf-H2C2_2	286..309	CDD:290200	13/22 (59%)
		C2H2 Zn finger	301..321	CDD:275368	9/19 (47%)
		zf-H2C2_2	313..338	CDD:290200	14/24 (58%)
		C2H2 Zn finger	329..349	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..366	CDD:290200	15/21 (71%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..396	CDD:290200	8/25 (32%)
		C2H2 Zn finger	385..407	CDD:275368	7/21 (33%)
		zf-H2C2_2	400..424	CDD:290200	9/25 (36%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-C2H2	441..463	CDD:278523	8/38 (21%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010