DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and CG8944

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	690	Identity:	131/690 - (18%)
Similarity:	209/690 - (30%)	Gaps:	268/690 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 TKADTTV----TVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDED------------- 191
            |.|||.:    .|:.:|   :..:...|::||.|. |:::.|.:..:|.|||
  Fly    99 TDADTALLEPQMVIKQE---LQDLPCSDDDVVAGE-EDDDEQRLNDSEADEDEAILPESDVPVVS 159

  Fly   192 ----------------------LGEDGDE--------------------------DGEDSSGKGN 208
                                  :..|||.                          ||.:.||.|.
  Fly   160 SKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDHSYMDDNSGEYMDFAGFDGVNHSGFGT 224

  Fly   209 SSQ-------------TKIKEIVEHVCGK-----CYKTFRRVQSLKKH----------------- 238
            .|.             .:.:|:..|:..:     ...:::|...|..|
  Fly   225 ESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKRARFLDW 289

  Fly   239 --LEFCRYDSGYHL--------RKADMLKNLEKIEKDAVVMEKKDICFCCSESYDTFHLGHIN-- 291
              |||   .|.:::        ||.|.|:.:.|.|.:.:.:||.:|    |..:....|..:|
  Fly   290 IVLEF---KSRFNISLAKDAITRKWDNLRTVYKRECNRMALEKTNI----STLWYFKELHFLNEV 347

  Fly   292 ---CPDCPKSFKTQTSYERHIFITHSE----------------FSDFPCSICNANLRSEAL--LA 335
               ......:...:|||.|......::                ::.|.....:...|.|.|  :|
  Fly   348 YSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYRSKERRGEGLHQMA 412

  Fly   336 LHEEQ--------------------HKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTM 380
            :..:|                    .|.:.:....:..||.|..:|.......:   ..::....
  Fly   413 IELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKFIANYLYYDQMHF---MDDDIPPF 474

  Fly   381 SCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPE----YMCHTCKNCFYSLSTLNIHIRTHTG---E 438
            .|..|..:...|..|..|:..|       :|.    |.|:.|...|::....:.|.:.|.|   |
  Fly   475 KCAHCPEIVQTLRELDLHMLTH-------QPSLGGGYYCNICSIQFHNAQEFDNHKQLHLGGVTE 532

  Fly   439 KPFDCDLCDKKFSALVALKKHRRYHTGE------------------------------------- 466
            ..|:|:||...|.......:|.|.|..|
  Fly   533 IKFNCELCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEIGVEGEESRGSGSRRK 597

  Fly   467 ----------------------------------KPYSCTVCNQAFAVKEVLNRHMKRHTGERP- 496
                                              |||.|.||.::||....||.|...|..||.
  Fly   598 RRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPGHLNAHRIVHQDERER 662

  Fly   497 -HKCD--ECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCA 556
             :|||  :|.|||:....|..|.|.|.  ..|.|:.|.:.||:.|.|:.|.:.|.:.||  :.|.
  Fly   663 CYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKTFKSTKNLQNHKQIHDKIKR--YVCQ 725

  Fly   557 ECKRNFRTPALLKEHMDEGKHSPKQQRSSMRSAVKIMERT 596
            .|...|...|.|..|        |::.:....||..:.|:
  Fly   726 ICGSAFAQAAGLYLH--------KRRHNRPNGAVGAVGRS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	4/20 (20%)
		COG5048	<312..517	CDD:227381	58/324 (18%)
		C2H2 Zn finger	321..341	CDD:275368	5/41 (12%)
		zf-C2H2	348..368	CDD:278523	4/19 (21%)
		C2H2 Zn finger	350..368	CDD:275368	4/17 (24%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		zf-H2C2_2	428..451	CDD:290200	8/25 (32%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	10/94 (11%)
		COG5048	<467..620	CDD:227381	46/136 (34%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		zf-H2C2_2	484..508	CDD:290200	13/27 (48%)
		C2H2 Zn finger	499..519	CDD:275368	9/21 (43%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	598..615	CDD:275371
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	18/91 (20%)
		MADF	379..472	CDD:214738	11/95 (12%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	8/19 (42%)
		zf-C2H2_8	639..712	CDD:292531	27/72 (38%)
		C2H2 Zn finger	666..688	CDD:275368	9/21 (43%)
		zf-C2H2	694..716	CDD:278523	8/21 (38%)
		C2H2 Zn finger	696..716	CDD:275368	7/19 (37%)
		zf-H2C2_2	708..733	CDD:290200	8/26 (31%)
		C2H2 Zn finger	724..744	CDD:275368	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010