DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and Zfp865

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_017177788.1	Gene:	Zfp865 / 319748	MGIID:	2442656	Length:	1120	Species:	Mus musculus

Alignment Length:	567	Identity:	124/567 - (21%)
Similarity:	189/567 - (33%)	Gaps:	187/567 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 LGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADML 256
            ||..|: .|....|.|..|:|       ..||.|.:.|.|.::||:|
Mouse   588 LGGAGN-GGAGGPGAGGPSKT-------FCCGICGRAFGRRETLKRH------------------ 626

  Fly   257 KNLEKIEKDAVVMEKKDICFCCSESY-DTFHLG--HI--------NCPDCPKSFKTQTSYERHIF 310
               |:|...    ||...|..|.:.: ::|||.  |:        .|..|.|.|....|..||..
Mouse   627 ---ERIHTG----EKPHQCPVCGKRFRESFHLSKHHVVHTRERPYKCELCGKVFGYPQSLTRHRQ 684

  Fly   311 ITHSEFS---------------------------------DFPCSICNANLRSEALLALHEEQHK 342
            :...:..                                 .:.||.|..:......:..|:|.|.
Mouse   685 VHRLQLPCALAGATGLATGQGTTGACGPGAAGTSGGPADLSYACSDCGEHFPDLFHVMSHKEAHM 749

  Fly   343 SRGKPYACKICGKDF----TRSYHLKRHQ--------------------------KYSSC----- 372
            |. |||.|..|||.|    ...:|...||                          ..||.
Mouse   750 SE-KPYGCDACGKTFGFIENLMWHKLVHQAAPERLLAPTPSGPQSSDGGSSGGGTDASSVLDNGL 813

  Fly   373 --------------------------------SSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGT 405
                                            :|:..:..||..|.:.|.....|.:|...||..
Mouse   814 AGEVGTAVAALAGVSGGSEDAGGATVAGSGGGTSSGAERFSCATCGQSFKHFLGLVTHKYVHLVR 878

  Fly   406 QVV-----------------------KKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCD 447
            :.:                       :|..:.|..|...|:..:.|..|.|.||.::|:.|.:|.
Mouse   879 RTLGCGLCGQSFAGAYDLLLHRRSHRQKRGFRCPVCGKRFWEAALLMRHQRCHTEQRPYRCGVCG 943

  Fly   448 KKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQL 512
            :.|.....|::||..||||:.:.|.||.:.||....|..|.:.|...||.:|..|||:|...:.|
Mouse   944 RGFLRSWYLRQHRVVHTGERAFKCGVCAKHFAQSSSLAEHRRLHAVARPQRCGACGKTFRYRSNL 1008

  Fly   513 RTHSKTHI--RPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEG 575
            ..|.:.|:  |.:.||.|.:.|.....:.||.:.| ...||...|..|.:.|:.|...::|:
Mouse  1009 LEHQRLHLGERAYRCEHCGKGFFYLSSVLRHQRAH-EPPRPELRCPACLKAFKDPGYFRKHL--- 1069

  Fly   576 KHSPKQQRSSMRSAVKIMERTDCAICDKNFDSSDTLRRHIRTVHECD 622
              :..|.....|          |:.|.:.|.::..|::| |.:|:.:
Mouse  1070 --AAHQGGRPFR----------CSSCGEGFANTYGLKKH-RLMHKAE 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	7/20 (35%)
		COG5048	<312..517	CDD:227381	66/327 (20%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		zf-C2H2	348..368	CDD:278523	9/49 (18%)
		C2H2 Zn finger	350..368	CDD:275368	8/47 (17%)
		C2H2 Zn finger	382..402	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	8/22 (36%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..479	CDD:290200	10/23 (43%)
		COG5048	<467..620	CDD:227381	41/154 (27%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	10/23 (43%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	4/16 (25%)
Zfp865	XP_017177788.1	PHA03378	<225..>411	CDD:223065
		C2H2 Zn finger	284..304	CDD:275368
		C2H2 Zn finger	312..332	CDD:275368
		PHA03247	<334..405	CDD:223021
		COG5048	411..>483	CDD:227381
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	471..491	CDD:275368
		C2H2 Zn finger	503..523	CDD:275370
		C2H2 Zn finger	610..630	CDD:275368	9/40 (23%)
		zf-H2C2_2	623..646	CDD:372612	9/47 (19%)
		C2H2 Zn finger	638..658	CDD:275368	6/19 (32%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	728..748	CDD:275368	5/19 (26%)
		C2H2 Zn finger	756..776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	855..875	CDD:275368	5/19 (26%)
		C2H2 Zn finger	883..903	CDD:275368	0/19 (0%)
		C2H2 Zn finger	911..931	CDD:275368	6/19 (32%)
		zf-H2C2_2	924..948	CDD:372612	9/23 (39%)
		C2H2 Zn finger	939..959	CDD:275368	6/19 (32%)
		C2H2 Zn finger	967..987	CDD:275368	7/19 (37%)
		C2H2 Zn finger	995..1015	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1023..1043	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1052..1072	CDD:275368	5/24 (21%)
		C2H2 Zn finger	1080..1100	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910