DRSC/TRiP Functional Genomics Resources

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Protein Alignment su(Hw) and ZBTB48

DIOPT Version :9

Sequence 1:NP_001247098.1 Gene:su(Hw) / 41740 FlyBaseID:FBgn0003567 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001265576.1 Gene:ZBTB48 / 3104 HGNCID:4930 Length:688 Species:Homo sapiens


Alignment Length:554 Identity:146/554 - (26%)
Similarity:223/554 - (40%) Gaps:95/554 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 GVENISPPKDKRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNKQEKRGSVAGSRIKILNEEILG 80
            |...:.||..:...:.:|  ...|..|:..:.|.....|    .||.|||.:..|.::       
Human   126 GQSGLGPPASQNVNSHVK--EPAGLEEEEVSRTLGLVPR----DQEPRGSHSPQRPQL------- 177

  Fly    81 TPKTEKRGATKSTAPAASTVKI--------LNEKKTPSATVTAVETTKIKTSPSKRKKMEHYVLQ 137
                  ....:|..|::...|:        |.:||.....|           |.:..:.|...||
Human   178 ------HSPAQSEGPSSLCGKLKQALKPCPLEDKKPEDCKV-----------PPRPLEAEGAQLQ 225

  Fly   138 AVKSENTKADTTVTVVTEEDDTIDFILADDEEVVPGRIENNNGQEIVVTEDDEDLGEDGDEDGED 202
            ...:|     ..|.|..|:|...|::  .:.|.|..|.::|..::....|.....|....|..|:
Human   226 GGSNE-----WEVVVQVEDDGDGDYM--SEPEAVLTRRKSNVIRKPCAAEPALSAGSLAAEPAEN 283

  Fly   203 SSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKH---------LEFCRYDSGYHLRKADMLKN 258
            ..|..          |...|..|:|.|.....||.|         .| |......:.||.::|::
Human   284 RKGTA----------VPVECPTCHKKFLSKYYLKVHNRKHTGEKPFE-CPKCGKCYFRKENLLEH 337

  Fly   259 LEKIEKDAVVMEKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSI 323
                       |.::   |.:.|...|     .|..|.::|:.:.....|: ::|:....:.||.
Human   338 -----------EARN---CMNRSEQVF-----TCSVCQETFRRRMELRVHM-VSHTGEMPYKCSS 382

  Fly   324 CNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRV 388
            |:.....:..|..|..:.....||:||..|.|.|.....|:.|:.:.....      ...||:..
Human   383 CSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKCFLSRTELQLHEAFKHRGE------KLFVCEEC 441

  Fly   389 FYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSAL 453
            .:|..: |:.|:.|:..:...:..::|..|.:.|...:.||:|:|||||||||.|.||.|.|...
Human   442 GHRASS-RNGLQMHIKAKHRNERPHVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHLCGKTFRTQ 505

  Fly   454 VALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHM-KRHTGERPHKCDECGKSFIQATQLRTHSK 517
            .:|.||.|.||||:|:||..|.|.|..|..|.||: .||...|||.|..|||:|....|||.|.:
Human   506 ASLDKHNRTHTGERPFSCEFCEQRFTEKGPLLRHVASRHQEGRPHFCQICGKTFKAVEQLRVHVR 570

  Fly   518 TH--IRPFPCEQCDEKFKTEKQLERHVKTHSRTK 549
            .|  :|.|.|.:|..||..:..|.||::.|.|.:
Human   571 RHKGVRKFECTECGYKFTRQAHLRRHMEIHDRVE 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
su(Hw)NP_001247098.1 C2H2 Zn finger 292..313 CDD:275368 4/20 (20%)
COG5048 <312..517 CDD:227381 73/205 (36%)
C2H2 Zn finger 321..341 CDD:275368 5/19 (26%)
zf-C2H2 348..368 CDD:278523 7/19 (37%)
C2H2 Zn finger 350..368 CDD:275368 6/17 (35%)
C2H2 Zn finger 382..402 CDD:275368 5/19 (26%)
C2H2 Zn finger 415..435 CDD:275368 7/19 (37%)
zf-H2C2_2 428..451 CDD:290200 16/22 (73%)
C2H2 Zn finger 443..463 CDD:275368 9/19 (47%)
zf-H2C2_2 455..479 CDD:290200 13/23 (57%)
COG5048 <467..620 CDD:227381 36/86 (42%)
C2H2 Zn finger 471..491 CDD:275368 8/20 (40%)
zf-H2C2_2 484..508 CDD:290200 13/24 (54%)
C2H2 Zn finger 499..519 CDD:275368 9/19 (47%)
C2H2 Zn finger 525..545 CDD:275368 7/19 (37%)
C2H2 Zn finger 555..572 CDD:275368
C2H2 Zn finger 598..615 CDD:275371
ZBTB48NP_001265576.1 BTB 16..119 CDD:306997
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..140 3/13 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..192 9/47 (19%)
C2H2 Zn finger 293..313 CDD:275368 7/19 (37%)
zf-H2C2_2 305..328 CDD:316026 5/23 (22%)
C2H2 Zn finger 321..372 CDD:275368 12/70 (17%)
SFP1 <374..459 CDD:227516 20/91 (22%)
C2H2 Zn finger 380..401 CDD:275368 5/20 (25%)
C2H2 Zn finger 409..425 CDD:275370 5/15 (33%)
C2H2 Zn finger 438..459 CDD:275368 5/21 (24%)
COG5048 <464..612 CDD:227381 64/141 (45%)
C2H2 Zn finger 467..487 CDD:275368 7/19 (37%)
C2H2 Zn finger 495..515 CDD:275368 9/19 (47%)
C2H2 Zn finger 523..540 CDD:275368 7/16 (44%)
C2H2 Zn finger 555..572 CDD:275368 8/16 (50%)
C2H2 Zn finger 580..600 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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