DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and Zfp438

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_017456046.1	Gene:	Zfp438 / 307024	RGDID:	1307214	Length:	800	Species:	Rattus norvegicus

Alignment Length:	696	Identity:	136/696 - (19%)
Similarity:	231/696 - (33%)	Gaps:	205/696 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GKEKKGKLLGVENISPPKD------------KRPATRMKLLNDVGAGEDSEASTTTTTSRTPSNK 59
            |:|....|:.:.|::..:.            |.|..|.:.|:..|..:..:.|:....||.|...
  Rat    87 GQEGTFSLVALPNVASAQPVQKPRMSIHENLKLPIPRYQPLSSKGLRKKHDLSSPKGGSRDPPGP 151

  Fly    60 QEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAP-----AASTVKI------------LNEKK 107
            .:........:   .:.|:|..|...||..|.:.:|     |..|..|            ..:.:
  Rat   152 AQLCHLSPSPQ---AHPELLHKPSPWKRMPTLNPSPTNINTATVTSAIGQGDLSPLETDSCGDLE 213

  Fly   108 TPSATVTAVETTKIKTSPSKRKK-----MEHYVLQAVKSENTKADTTV--TVVTEEDDTIDFILA 165
            .|:....:.|.:..::.|:..:|     .|.....||.||..:.....  :||:....::..:..
  Rat   214 PPAIPAYSTENSSPQSLPASMQKAGCARKETPTKPAVASEELQEQVAPAHSVVSSTVQSVSVVTK 278

  Fly   166 DDEEVVP-GRIENNNGQEIVVTEDDEDLGEDGDEDGEDSSG------------KGNSSQTKIKEI 217
            |...::| .|::..   |:|..|.|.:..|      ..|||            :|..:.|:|...
  Rat   279 DKLPILPSSRVKTT---EVVKVEPDAENAE------SSSSGCRANCEERLSITEGFDAATEIANK 334

  Fly   218 VEHVCGK----CYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLE------KIEKDAVVME-K 271
            ...:.|.    |...|..|..|..:            |||.....::      |:..|.:.:: |
  Rat   335 TPALHGSKQSACKSAFCPVTKLDLN------------RKAKPSSGVKRRGRKWKVPDDILALQGK 387

  Fly   272 KDICF--CCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALL 334
            :..|.  .|.:|.:...    |.|..|:..|.:.:..::..|...     |..:.:|.....:..
  Rat   388 RRRCIIGMCGDSIERAR----NNPPEPRDQKPRATSRKYRSIMPK-----PVIVLSALAPLASPA 443

  Fly   335 ALHEEQHKSRGK-------PYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRL 392
            |:..:.....|:       |..|                     .||.::|.::.|....
  Rat   444 AMLSQAPSGLGQDVLNNALPPKC---------------------LSSKQSDNLAPKPSSA----- 482

  Fly   393 DNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALK 457
              ||:      |...:|||.:||..|          |.|.:       |...|.|
  Rat   483 --LRN------GFSGIKKPWHMCPVC----------NYHFQ-------FKHHLLD---------- 512

  Fly   458 KHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGE-RPHK---CDECGKSFIQATQLRTHSKT 518
             |...||..:||||.:|.:.:.....|:.|||.|.|: ||.|   |:.|.|.|           .
  Rat   513 -HMNTHTNRRPYSCGICRKTYVRPGSLSAHMKLHHGDNRPKKLVCCEFCAKVF-----------G 565

  Fly   519 HIRPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEGKHS--PKQ 581
            |:|.:        |...|::.|.|.:...|...:.|....|...|.|::      :|..|  .::
  Rat   566 HVRVY--------FGHLKEVHRVVISTEPTPSELQSEDTPKNKDRDPSM------QGPDSSLERE 616

  Fly   582 QRSSMR--------SAVKIMERTDCAICDKNFDSSDTLRRHIRTVH 619
            .:||:.        ..||:..|  |..|.....|...::.|:..||
  Rat   617 TKSSLEEDFLLNQADEVKLQIR--CGRCQITAQSFAEIKFHLLHVH 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	4/20 (20%)
		COG5048	<312..517	CDD:227381	45/215 (21%)
		C2H2 Zn finger	321..341	CDD:275368	2/19 (11%)
		zf-C2H2	348..368	CDD:278523	1/19 (5%)
		C2H2 Zn finger	350..368	CDD:275368	1/17 (6%)
		C2H2 Zn finger	382..402	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		zf-H2C2_2	428..451	CDD:290200	5/22 (23%)
		C2H2 Zn finger	443..463	CDD:275368	3/19 (16%)
		zf-H2C2_2	455..479	CDD:290200	8/23 (35%)
		COG5048	<467..620	CDD:227381	42/167 (25%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	13/27 (48%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	525..545	CDD:275368	4/19 (21%)
		C2H2 Zn finger	555..572	CDD:275368	3/16 (19%)
		C2H2 Zn finger	598..615	CDD:275371	3/16 (19%)
Zfp438	XP_017456046.1	C2H2 Zn finger	497..517	CDD:275368	8/47 (17%)
		zf-H2C2_2	509..534	CDD:290200	10/35 (29%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		C2H2 Zn finger	557..575	CDD:275368	7/36 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100