DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and ZNF660

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_775929.2	Gene:	ZNF660 / 285349	HGNCID:	26720	Length:	331	Species:	Homo sapiens

Alignment Length:	347	Identity:	112/347 - (32%)
Similarity:	163/347 - (46%)	Gaps:	31/347 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 RKADMLKNLEKIEKDAVVM-------EKKDICFCC----SESYDTFHLGHINCPDCPKSFKTQTS 304
            ||....|:  |..||..|:       .:||...||    :|........:: |.:|.|:|....:
Human     3 RKTRNFKH--KTVKDNKVLTEGSDQESEKDNSQCCDPATNERVQAEKRQYV-CTECGKAFSQSAN 64

  Fly   305 YERHIFITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKY 369
            ...|..| |:....:.|..|.......:.|.:|...|... |||.|..|||.|:...||.|||..
Human    65 LTVHERI-HTGEKPYKCKECGKAFSHSSNLVVHRRIHTGL-KPYTCSECGKSFSGKSHLIRHQGI 127

  Fly   370 SSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRT 434
            .|...    |..||.|.:.|.|...|.||.:.|.|    :|| |.|..|...|...|.|..|.|.
Human   128 HSGEK----TYECKECGKAFSRSSGLISHHRVHTG----EKP-YSCIECGKAFSRSSNLTQHQRM 183

  Fly   435 HTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKC 499
            |.|:|.:.|..|.|...:...:..|:|.|||||||.|..|.:.|.:::.||.|.:.|..|:|:||
Human   184 HRGKKVYKCKECGKTCGSNTKIMDHQRIHTGEKPYECDECGKTFILRKTLNEHQRLHRREKPYKC 248

  Fly   500 DECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNF 562
            :||||:|.....|..|.:.|.  :|:.|.:|.:.|:...|:..|::||  ||...:.|:||.:.:
Human   249 NECGKAFTSNRNLVDHQRVHTGEKPYKCNECGKTFRQTSQVILHLRTH--TKEKPYKCSECGKAY 311

  Fly   563 RTPALLKEHMDEGKHSPKQQRS 584
            |..:.|.:|  :.||:.:::.|
Human   312 RYSSQLIQH--QRKHNEEKETS 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	6/20 (30%)
		COG5048	<312..517	CDD:227381	74/204 (36%)
		C2H2 Zn finger	321..341	CDD:275368	4/19 (21%)
		zf-C2H2	348..368	CDD:278523	10/19 (53%)
		C2H2 Zn finger	350..368	CDD:275368	9/17 (53%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..451	CDD:290200	9/22 (41%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		zf-H2C2_2	455..479	CDD:290200	11/23 (48%)
		COG5048	<467..620	CDD:227381	41/120 (34%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	13/23 (57%)
		C2H2 Zn finger	499..519	CDD:275368	8/19 (42%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	598..615	CDD:275371
ZNF660	NP_775929.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		9/33 (27%)
		C2H2 Zn finger	52..72	CDD:275368	6/20 (30%)
		zf-H2C2_2	64..89	CDD:316026	5/25 (20%)
		C2H2 Zn finger	80..100	CDD:275368	4/19 (21%)
		COG5048	<107..294	CDD:227381	72/195 (37%)
		C2H2 Zn finger	108..128	CDD:275368	10/19 (53%)
		C2H2 Zn finger	136..156	CDD:275368	8/19 (42%)
		C2H2 Zn finger	164..184	CDD:275368	7/19 (37%)
		C2H2 Zn finger	192..207	CDD:275368	3/14 (21%)
		C2H2 Zn finger	220..240	CDD:275368	6/19 (32%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	5/19 (26%)
		C2H2 Zn finger	304..324	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100