DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and Zfp148

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_006522161.1	Gene:	Zfp148 / 22661	MGIID:	1332234	Length:	800	Species:	Mus musculus

Alignment Length:	724	Identity:	158/724 - (21%)
Similarity:	253/724 - (34%)	Gaps:	211/724 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 VCGKCYKTFRRVQSLKKHLEFCRYD---SGYHLRKADMLKNLEKIEKDAVVMEKKDICFCCSESY 282
            |.|:..::..:.:|| .|.|....|   ....:|:.||:.:.|.:..:..|  |.|     .|..
Mouse    38 VSGELQESVLQDRSL-PHQEILAADEVLQESEMRQQDMISHDELMVHEETV--KND-----EEQM 94

  Fly   283 DTFHLGHINCP-------DCPKSFKTQTSYERHIFITHSEFSDFPCSICNANLRSEALLALHEEQ 340
            ||    |...|       :.|.|.|.:.:           |:|....:.....:....:.|.:::
Mouse    95 DT----HERLPQGLQYALNVPISVKQEIT-----------FTDVSEQLMRDKKQVREPVDLQKKK 144

  Fly   341 HKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSNETDTMSCKVCDRVFYRLDNLRSHLKQHLGT 405
            .:.:..|...:.|.|..|               .||.                          |:
Mouse   145 KRKQRSPAKVRDCAKILT---------------INED--------------------------GS 168

  Fly   406 QVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTGEKPYS 470
            ..:|.|:  .|.|::|..:..| |.|                        |::|...||||||:.
Mouse   169 LGLKTPK--SHVCEHCNAAFRT-NYH------------------------LQRHVFIHTGEKPFQ 206

  Fly   471 CTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHI--RPFPCEQCDEKF- 532
            |:.|:..|..|.:|.||.|.||||:|.:|||||..|||...:..|.:||.  :|:.||.|.:.|
Mouse   207 CSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFS 271

  Fly   533 KTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALLKEHMDEG-KHSPK------------QQRS 584
            :|::.|:.....|....:.:..||      ....||....|.| ..|||            :::|
Mouse   272 RTDRVLKHKRMCHENHDKKLNRCA------IKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKS 330

  Fly   585 SMRSAVKIMERTDCAICDKN-----FDSSDTLRRHI-----------RTVHECDPDDIFGVEPHP 633
            |......:::::|.. .|||     :.||..::...           .:|.....:|..| |.||
Mouse   331 SGMDKESVLDKSDLK-KDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASG-EIHP 393

  Fly   634 SKRAKKDIESEEVVPVALNTSAG-SLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPL 697
            .|...|.|.|:..:...|..|.. |.:||..|.........|||:              ..:|..
Mouse   394 PKLVLKKINSKRSLKQPLEQSQTISPLSSYEDSKVSKYAFELVDK--------------QALLDS 444

  Fly   698 DGAIEGEQLTD--EAGVKPEAKKEEAQVSPVVKKEQRKSLAAS-------------------LAA 741
            :|:.:.:|:.:  |...||.........:....|::|...|||                   ..|
Mouse   445 EGSADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQA 509

  Fly   742 AIADNLEESCSEDDFSGEILTEEDIKLKENVGK-LIDMLVDPPILKKYGW-PNAPEE-------T 797
            |:|..::||.:......:.|   ::::|.|..| :|...|...:|..|.. ||...|       |
Mouse   510 AVASVIDESTTASILDSQAL---NVEIKSNHDKNVIPDEVLQTLLDHYSHKPNGQHEISFSVADT 571

  Fly   798 VLCKVI-------------ENCGHDLTKGGENYAELDYGSRMREYCKLLFTVVIHNDSIKSLLN- 848
            .:...|             ||.|     .....:..|..:.::||.|.|...:.......:.||
Mouse   572 EVTSSISINSSDVPEVTQSENVG-----SSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNS 631

  Fly   849 ---NFPIDD 854
               ||..|:
Mouse   632 PSLNFVTDN 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	4/27 (15%)
		COG5048	<312..517	CDD:227381	48/204 (24%)
		C2H2 Zn finger	321..341	CDD:275368	1/19 (5%)
		zf-C2H2	348..368	CDD:278523	3/19 (16%)
		C2H2 Zn finger	350..368	CDD:275368	3/17 (18%)
		C2H2 Zn finger	382..402	CDD:275368	0/19 (0%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	2/22 (9%)
		C2H2 Zn finger	443..463	CDD:275368	2/19 (11%)
		zf-H2C2_2	455..479	CDD:290200	10/23 (43%)
		COG5048	<467..620	CDD:227381	52/184 (28%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		zf-H2C2_2	484..508	CDD:290200	15/23 (65%)
		C2H2 Zn finger	499..519	CDD:275368	9/19 (47%)
		C2H2 Zn finger	525..545	CDD:275368	6/20 (30%)
		C2H2 Zn finger	555..572	CDD:275368	4/16 (25%)
		C2H2 Zn finger	598..615	CDD:275371	5/21 (24%)
Zfp148	XP_006522161.1	zf-C2H2	177..199	CDD:333835	8/46 (17%)
		C2H2 Zn finger	179..199	CDD:275368	7/44 (16%)
		zf-H2C2_2	191..216	CDD:372612	12/48 (25%)
		C2H2 Zn finger	207..227	CDD:275368	8/19 (42%)
		zf-H2C2_2	220..244	CDD:372612	15/23 (65%)
		C2H2 Zn finger	235..255	CDD:275368	9/19 (47%)
		zf-H2C2_2	247..272	CDD:372612	8/24 (33%)
		C2H2 Zn finger	263..281	CDD:275368	6/17 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000