DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment su(Hw) and Zfp281

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001153723.1	Gene:	Zfp281 / 226442	MGIID:	3029290	Length:	893	Species:	Mus musculus

Alignment Length:	529	Identity:	119/529 - (22%)
Similarity:	191/529 - (36%)	Gaps:	139/529 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 GTQVVKKPEYMCHTCKNC---FYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALVALKKHRRYHTG 465
            |...|..|....|.|.:|   |.|...|..|:..||||:||.|..|...|.....|::|.:.|:.
Mouse   246 GEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSR 310

  Fly   466 EKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHSKTHIRPFPCEQCDE 530
            |||:.|..|:..|..|..:.||.:.|:||:|:|||.|.:.|.:..:|..|.:|         |.|
Mouse   311 EKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRT---------CGE 366

  Fly   531 KF-KTEKQLERHVKTH-SRTKRPVFS---CAECKRNFRTPALL---KEHMDEGKHSPKQQRSSMR 587
            .. |.....|.....| |.....|.|   .:..:|..::.::.   ||| ..||.:..|..:::.
Mouse   367 AIAKGAASAEPGSSNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEH-KTGKTNESQMSNNIN 430

  Fly   588 SAVKIME----RTDCAICDKNFDSSDTLRRHIRTV-------HECDPDDIFGVEPHPSKRAKKDI 641
            .....:|    .|..:|.....|.   |::.:..:       ...|...:..|.|.|....:|.:
Mouse   431 MQSYSVEMPTVSTSGSIIGTGIDE---LQKRVPKLIFKKGSRKNADKSYLNFVSPLPDVVGQKSL 492

  Fly   642 ESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDEGDGAAQTITLENETYTILPLDGAI----- 701
            ..:         ..|||        |:|        .:.:.:||:|...|   ....|.|
Mouse   493 SGK---------PGGSL--------GIV--------SNNSVETISLLQST---SGKQGPISSNYD 529

  Fly   702 EGEQLTDEAGVKPEAKKEEAQVSPVVKKEQRKSLAASLAAAIADNLE--------------ESCS 752
            :..|.:.:....|.|....|....|.....::|:..|...::.||..              :||.
Mouse   530 DAMQFSKKRRYLPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCH 594

  Fly   753 E-------------DDFSGEILTEEDIKLKENVGKLIDMLVDPPILKKYGWPNAPEETVLCKVIE 804
            :             |.:||:..|:     ||:...|.:..||   |...|     |.:.|.:. |
Mouse   595 DKSGIPDEVLQSILDQYSGKSETQ-----KEDPFNLTEPRVD---LHTSG-----EHSELVQE-E 645

  Fly   805 NCGHDLTKGGENYAELDYGSRMREYCKLL-----------FTV-----------VIHNDSI---K 844
            |    |:.|.:..:. |..|.::||.|.|           ||:           .:||.::   |
Mouse   646 N----LSPGTQTPSN-DKTSMLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEK 705

  Fly   845 SLLNNFPID 853
            .:....|::
Mouse   706 QIYTTSPLE 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368
		COG5048	<312..517	CDD:227381	42/115 (37%)
		C2H2 Zn finger	321..341	CDD:275368
		zf-C2H2	348..368	CDD:278523
		C2H2 Zn finger	350..368	CDD:275368
		C2H2 Zn finger	382..402	CDD:275368
		C2H2 Zn finger	415..435	CDD:275368	7/22 (32%)
		zf-H2C2_2	428..451	CDD:290200	10/22 (45%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		zf-H2C2_2	455..479	CDD:290200	8/23 (35%)
		COG5048	<467..620	CDD:227381	40/171 (23%)
		C2H2 Zn finger	471..491	CDD:275368	6/19 (32%)
		zf-H2C2_2	484..508	CDD:290200	11/23 (48%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	525..545	CDD:275368	4/20 (20%)
		C2H2 Zn finger	555..572	CDD:275368	3/19 (16%)
		C2H2 Zn finger	598..615	CDD:275371	3/16 (19%)
Zfp281	NP_001153723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..148
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..251		1/4 (25%)
		zf-C2H2	258..280	CDD:278523	7/21 (33%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	11/24 (46%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		zf-H2C2_2	301..325	CDD:290200	9/23 (39%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	11/24 (46%)
		C2H2 Zn finger	344..363	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..425		11/54 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..658		15/63 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..815
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000