DRSC/TRiP Functional Genomics Resources

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Protein Alignment su(Hw) and bcl-11

DIOPT Version :9

Sequence 1:NP_001247098.1 Gene:su(Hw) / 41740 FlyBaseID:FBgn0003567 Length:941 Species:Drosophila melanogaster
Sequence 2:NP_001122913.1 Gene:bcl-11 / 179019 WormBaseID:WBGene00017430 Length:694 Species:Caenorhabditis elegans


Alignment Length:661 Identity:133/661 - (20%)
Similarity:198/661 - (29%) Gaps:259/661 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 SNKQEKRGSVAGSRIKILNEEILGTPKTEKRGATKSTAPAASTVKI---LNEKK----------- 107
            |..|....|.||.|.:..|.|:       ..||.:.||.::|..|.   |:.||           
 Worm     6 SKSQTIETSSAGRRRRKANSEV-------DSGAEEPTATSSSDDKSDYRLDLKKRLTTFLTSNSQ 63

  Fly   108 --TPSATVTAVETT------KIKTSPSKRKKMEHYVLQAVKSENTKADTTVTVVTEEDDTIDFIL 164
              :..:.|:.||:|      ::|.|.|   .|.|   ....|...:.|.|..||..|..| .|.|
 Worm    64 MASSDSGVSGVESTVEHDLSELKASDS---PMSH---DGADSPRPELDRTDIVVCGECHT-SFSL 121

  Fly   165 --------------------ADDEEVVP-------------------GRIENNN----GQEIVVT 186
                                :||.||.|                   ||..:.|    ...:.||
 Worm   122 SCFSNFIEHKVSNCGGKLTPSDDCEVTPRNFDRSRRRTFNPAALIRCGRSTSANALLPNYNMDVT 186

  Fly   187 EDDEDLGEDGDEDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKH------LEFC--- 242
            .|..|||         ||.|..:            |..|.:.|..|.:|.||      |..|   
 Worm   187 TDTNDLG---------SSSKSLT------------CCNCKERFGDVWTLLKHSYDIHGLRVCQEA 230

  Fly   243 ------------------------RYDSGYHLRK-----------------ADMLKNL-----EK 261
                                    ||:......|                 ::.||.:     |:
 Worm   231 IPESDVSVTSTSSPTSNESMHMSSRYNHNDTSSKIMHQTIKSESTMMNSFCSERLKEIVTRAGEQ 295

  Fly   262 IEKDAVVM---------EKKDICFCCSESYDTFHLGHINCPDCPKSFKTQTSYERHIFITHSEFS 317
            .:|..:.:         |::.:....|.|...........|....|...|||             
 Worm   296 DQKPLMALRRLMPSEETEEEQVSAFTSTSLLNSRASQPQLPTVSSSAGFQTS------------- 347

  Fly   318 DFPCSICNANLRSEALLALHEEQHKSRGKPY------ACKICG------KDFTRSYHLKRHQKYS 370
               .|:.|..::...|.|:.|.....:..||      |..:..      :...:...|::.|:..
 Worm   348 ---GSMPNVWMQPSMLAAMQEYYASIQQMPYPMTNSTAVALLNISNNLQQQQQQQQQLQQQQQNL 409

  Fly   371 SCSSNETDTMSCKVCDRVFYRLDNL------------------------------RSHLK----- 400
            ..:..:..|........:|..|:.|                              |..:|     
 Worm   410 IAAQPQVATPQPPAPTPLFQSLNRLSTADESSYTPRPASVAIRRRASPEEELTPPRKSMKIEEED 474

  Fly   401 -------QHLGTQVVKKPEYM----CHTCKNCFYSLSTLNIHIRTHTGEKPFDCDLCDKKFSALV 454
                   ..|.....:||..:    |:.|...|.:.|.|.:|:|:||||||:.|.||....:...
 Worm   475 QLIVVDDGELAEPAARKPNNIKKERCNFCNKVFTNRSNLIVHLRSHTGEKPYKCQLCPYACAQSS 539

  Fly   455 ALKKHRRYH--TGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKSFIQATQLRTHS- 516
            .|.:|.|.|  .|::.|.|.:|...|:|...|.:||:        ||       :.:||.|... 
 Worm   540 KLTRHMRTHGQQGKETYHCYICRMPFSVHSTLEKHMR--------KC-------VVSTQGRREGG 589

  Fly   517 ---KTHIRPFP 524
               :..|||.|
 Worm   590 SPPERSIRPTP 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
su(Hw)NP_001247098.1 C2H2 Zn finger 292..313 CDD:275368 5/20 (25%)
COG5048 <312..517 CDD:227381 53/268 (20%)
C2H2 Zn finger 321..341 CDD:275368 5/19 (26%)
zf-C2H2 348..368 CDD:278523 3/31 (10%)
C2H2 Zn finger 350..368 CDD:275368 1/23 (4%)
C2H2 Zn finger 382..402 CDD:275368 5/61 (8%)
C2H2 Zn finger 415..435 CDD:275368 7/19 (37%)
zf-H2C2_2 428..451 CDD:290200 12/22 (55%)
C2H2 Zn finger 443..463 CDD:275368 6/19 (32%)
zf-H2C2_2 455..479 CDD:290200 8/25 (32%)
COG5048 <467..620 CDD:227381 17/62 (27%)
C2H2 Zn finger 471..491 CDD:275368 7/19 (37%)
zf-H2C2_2 484..508 CDD:290200 5/23 (22%)
C2H2 Zn finger 499..519 CDD:275368 4/23 (17%)
C2H2 Zn finger 525..545 CDD:275368 133/661 (20%)
C2H2 Zn finger 555..572 CDD:275368
C2H2 Zn finger 598..615 CDD:275371
bcl-11NP_001122913.1 zf-C2H2 499..520 CDD:278523 7/20 (35%)
zf-C2H2_2 500..>577 CDD:289522 29/84 (35%)
C2H2 Zn finger 500..520 CDD:275368 7/19 (37%)
zf-H2C2_2 512..537 CDD:290200 12/24 (50%)
C2H2 Zn finger 528..548 CDD:275368 6/19 (32%)
C2H2 Zn finger 558..576 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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