DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment su(Hw) and LOC110437786

DIOPT Version :9

Sequence 1:	NP_001247098.1	Gene:	su(Hw) / 41740	FlyBaseID:	FBgn0003567	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	XP_017211305.1	Gene:	LOC110437786 / 110437786	-ID:	-	Length:	578	Species:	Danio rerio

Alignment Length:	578	Identity:	156/578 - (26%)
Similarity:	236/578 - (40%)	Gaps:	119/578 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 EDGEDSSGKGNSSQTKIKEIVEHVCGKCYKTFRRVQSLKKHLEFCRYDSGYHLRKADMLKNLEKI 262
            |:.||...|..:.:.:|||..|.:      :...|.::|.  |.....:|..:.|.:..:..|..
Zfish     6 EENEDVWIKEENEELRIKEESEGL------SITEVFTVKH--EDPEEQTGLMVLKEETRELNEIE 62

  Fly   263 EKDAVVMEKKDICFCCSESYDTF-----------------HLGHINCPDCPKSFKTQTSYERHIF 310
            |||.           |.:.:|..                 ...|..|..|.|||..:.....|:.
Zfish    63 EKDQ-----------CGKQFDLMTDEPSSVAKNTSCEGAEKTKHFPCHQCGKSFSRKHGLNLHMR 116

  Fly   311 ITHSEFSDFPCSICNANLRSEALLALHEEQHKSRGKPYACKICGKDFTRSYHLKRHQKYSSCSSN 375
            | |:....:.|::|..:..:::....|...|... |||:|.:|||.||.......|.:..:...
Zfish   117 I-HTGEKPYSCTVCGKSFSAKSGFNTHMRIHTGE-KPYSCTVCGKSFTEKSRFNIHMRIHTGER- 178

  Fly   376 ETDTMSCKVCDRVFYRLDNLRSHLKQHLGTQVVKKPEYMCHTCKNCFYSLSTLNIHIRTHTGEKP 440
               ..||.||::.|.....|..|::.|.|    :|| |.|..|...|...|.|.:|:|.||||||
Zfish   179 ---PFSCTVCEKSFNEKKKLEIHMRIHTG----EKP-YSCTECGKSFSEKSKLGMHMRIHTGEKP 235

  Fly   441 FDCDLCDKKFSALVALKKHRRYHTGEKPYSCTVCNQAFAVKEVLNRHMKRHTGERPHKCDECGKS 505
            |.|..|.|:||.:|:||.|.|.||||||::|..|.::||.|..|..|:.|||||:|..||:|.|.
Zfish   236 FACQHCGKRFSQMVSLKSHFRVHTGEKPHTCQQCGKSFAQKSTLTAHIIRHTGEKPFPCDQCEKR 300

  Fly   506 FIQATQLRTHSKTHIRP--FPCEQCDEKFKTEKQLERHVKTHSRTKRPVFSCAECKRNFRTPALL 568
            ::....|:.|.:.|.:.  |.|:||...||.::..::|:|.|:...   |.|.:|.||..:.:.|
Zfish   301 YVCKHHLKRHKRIHAKHKYFICDQCGSSFKLKQNFDQHMKNHAEKS---FICDQCGRNCISESGL 362

  Fly   569 KEHM------------DEGKHSPKQQRSSMRSAVKIMERT-DCAICDKNFDSSDTLRRHIRTVHE 620
            :.||            :.||....:...::...|...|:. .|..|.|.|.:|..|:.|: ..|.
Zfish   363 ESHMKVHTGEKPYSCTECGKSCSHKHNLTVHMRVHTGEKPFQCHHCGKRFVTSYLLKSHM-NFHT 426

  Fly   621 CDPDDIFGVEPHPSKRAKKDIESEEVVPVALNTSAGSLISSQTDGNGVVVREFLVDE-GDGAAQT 684
                   |.:||..:...|.......:.|.|...:|.             |.:...: |.|.||.
Zfish   427 -------GKKPHTCRPCGKRFVQYSALKVHLRVHSGE-------------RPYTCAQCGKGFAQK 471

  Fly   685 --ITLENETYTILPLDGAIEGEQ---------------------LTDEAGVKPEAKKE 719
              :.:...|:|         ||:                     .|...|:||.|.||
Zfish   472 HGLYVHMRTHT---------GEKPFTCTQCGKSFTSKKSQVIHMRTHHTGIKPFACKE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
su(Hw)	NP_001247098.1	C2H2 Zn finger	292..313	CDD:275368	7/20 (35%)
		COG5048	<312..517	CDD:227381	76/204 (37%)
		C2H2 Zn finger	321..341	CDD:275368	3/19 (16%)
		zf-C2H2	348..368	CDD:278523	8/19 (42%)
		C2H2 Zn finger	350..368	CDD:275368	7/17 (41%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..451	CDD:290200	13/22 (59%)
		C2H2 Zn finger	443..463	CDD:275368	10/19 (53%)
		zf-H2C2_2	455..479	CDD:290200	12/23 (52%)
		COG5048	<467..620	CDD:227381	50/167 (30%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..508	CDD:290200	12/23 (52%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		C2H2 Zn finger	555..572	CDD:275368	5/16 (31%)
		C2H2 Zn finger	598..615	CDD:275371	6/16 (38%)
LOC110437786	XP_017211305.1	COG5048	91..511	CDD:227381	131/463 (28%)
		C2H2 Zn finger	98..118	CDD:275368	7/20 (35%)
		C2H2 Zn finger	126..146	CDD:275368	3/19 (16%)
		C2H2 Zn finger	154..174	CDD:275368	7/19 (37%)
		C2H2 Zn finger	182..202	CDD:275368	6/19 (32%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	238..258	CDD:275368	10/19 (53%)
		C2H2 Zn finger	266..286	CDD:275368	7/19 (37%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	2/19 (11%)
		C2H2 Zn finger	405..425	CDD:275368	7/20 (35%)
		C2H2 Zn finger	433..453	CDD:275368	3/19 (16%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		C2H2 Zn finger	489..509	CDD:275368	0/19 (0%)
		C2H2 Zn finger	518..538	CDD:275368	2/3 (67%)
		C2H2 Zn finger	544..560	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910