Protein Alignment MCM5 and rec

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_732072.1
• Gene: rec / 49241
• FlyBaseID: FBgn0003227
• Length: 885
• Species: Drosophila melanogaster
• Alignment Length: 788
• Identity: 183/788 - (23%)
• Similarity: 316/788 - (40%)
• Gaps: 186/788 - (23%)

Human    38 FLRQ-YRVGTD-------------RTGFTFKY---RDE---------LKRHYNLGEYWIEVEMED 76
            |||: |..|.:             |...||.:   ||.         :|....|.|.|
  Fly   119 FLREKYEEGNELATRIMAVEAYYQRNPHTFDFVMIRDRGFFPLCAAGIKSDAQLKEVW------- 176

Human    77 LASFDEDLADYLYKQPAEHLQLLEEAAKEVA--------DEVTRPRPSGEEVLQDIQVMLKSDAS 133
             .|..||:.::    |...|..|..|...|.        |..|....:.|:.:.....:.|..|.
  Fly   177 -PSLSEDIREH----PLRTLGTLSLAMHTVVVNHQLDCNDSTTAMVSTPEQYVLPTPRVRKIYAR 236

Human   134 P------SSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYA 192
            |      .||..:....:..|..|.|.:..........|..:.:|..|:   ..||||.  .|..
  Fly   237 PDDFVPVESIEGISHSRVDTLFSIRGFVSNVGEPSYSLTWQAFRCSRCQ---MEIAMRQ--RGTF 296

Human   193 LPRKCNTDQAGRPKC-------PL--DPYFIMPDKCKCVDFQTLKLQELPDAVPHG---EMPRHM 245
            .||..   |..|.:|       ||  .||..:..:      |.::::|....:.|.   .||..|
  Fly   297 QPRPY---QCKRSECVARDEFVPLRSSPYTRLSIR------QIIRVEESSLNLVHDFETSMPAEM 352

Human   246 QLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSF 310
            .:.....|.|.|..|..|.:.||..:::.|..|:.|...   .....|::.:.|: |.....|.|
  Fly   353 DVELRHDLVDAVRVGQEVVVTGILKLQELGDDTTTGDTS---NQMQPYLKAVSIR-DASSIKREF 413

Human   311 AGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACL--LFGGSRKRLPDGLTRRG 373
                |.::.|....:.|.||.::::.:||||.:: |.::.|| |||  |.||.      |.....
  Fly   414 ----SERDLEAIVMINAEPNSFKLLVQSIAPEVY-GHELPKA-ACLLSLLGGK------GAETEA 466

Human   374 DINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGK-GSSAA---GLTASVMRDPSSRN-FIMEGGA 433
             ||:|::||||..|:::|:...:.:..|.:.||| |:.:|   |:|.      :.|| .:::.|:
  Fly   467 -INVLLVGDPGIGKTKILQSCAQIAERGAHVSGKRGAQSAQQLGVTF------AGRNKRVLQAGS 524

Human   434 MVLADGGVVC-IDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDE 497
            :::|.||..| :|:.||:.....|.: :.::.:.:::..||...:..::.||:|.||...|::||
  Fly   525 LMMASGGGHCTLDDVDKLASKQAVLL-QCLQSEEVNLPLAGAFASFPAQPSVIACANPQRGQYDE 588

Human   498 TKGE---DNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAV--------- 550
              |.   .||:..|::|..|.:::|:.|:.: |||:.|..||..||..|..:.:..
  Fly   589 --GRYLLQNINISPSLLREFHLVYILLDKPS-ERDMSLTAHVRALHAGARKRARIAARYALKPKM 650

Human   551 ----------------------------------------------EGEIDLAK---LKKFIAYC 566
                                                          ||::||..   :|||::|.
  Fly   651 SDSMCEVSLNVPAAGKDDDTIKTEDDNDSIMQQDYDLDKRLEVLPEEGDLDLLPPILIKKFLSYA 715

Human   567 RVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPF 631
            |.:..|.|:.:|:..:. ||.:...|:...:.|    .|..|...||.||:.:::|.:::.|...
  Fly   716 RQELNPVLNEDASNAVL-RYFLELKGSCNLDED----VSSQIGAGQLLAIIHLSQARARLDLSHV 775

Human   632 ATEADVEEALRLFQVSTLDAAL------SGTL-SGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQV 689
            .:...|.:.:.|...|....:|      .||. .|..|..:.:..::.:.:|...:|..|:|.::
  Fly   776 VSPQHVRDVIALLTESITQTSLKEGSSRQGTRGGGGAGGGAGKSAQLRNFLELTKRRSAALGRRI 840

Human   690 SEHSIIKD 697
            .|...:|:
  Fly   841 FEFDELKE 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	25/125 (20%)
		MCM	133..649	CDD:214631	145/602 (24%)
rec	NP_732072.1	Mcm2	177..799	CDD:440854	159/671 (24%)
		MCM8	433..791	CDD:350665	95/381 (25%)
		MCM8_WHD	819..883	CDD:439328	6/30 (20%)