Protein Alignment MCM5 and Mcm5

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_524308.2
• Gene: Mcm5 / 41296
• FlyBaseID: FBgn0017577
• Length: 733
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 506/737 - (68%)
• Similarity: 617/737 - (83%)
• Gaps: 9/737 - (1%)

Human     1 MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNL 65
            |.||||.|:|:||:||||.|.| .|.....:::::|||:|.:    :...|.:||||.|||:|..
  Fly     1 MEGFDDAGVFFSDNFGGDNQQD-AQINLQAVKKKYKEFIRTF----NEENFFYKYRDTLKRNYLN 60

Human    66 GEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKS 130
            |.|::|:|||||..|||.|||.|.|||.|||::.||||:|||||:|.|||..||.:.|||::|.|
  Fly    61 GRYFLEIEMEDLVGFDETLADKLNKQPTEHLEIFEEAAREVADEITAPRPEHEEHMHDIQILLSS 125

Human   131 DASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPR 195
            :|:|::||.||||.:|.||||.|||:|||.:.|||||:||||.||...:.|:.:.||||||||||
  Fly   126 NANPTNIRQLKSDCVSKLVKIAGIIVAASGISAKATRMSIQCLSCSTVIPNLKVNPGLEGYALPR 190

Human   196 KCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPG 260
            ||||:|||||||||||:||||||||||||||||||||||.||.||:|||:||:|||.||::||||
  Fly   191 KCNTEQAGRPKCPLDPFFIMPDKCKCVDFQTLKLQELPDFVPQGEIPRHLQLFCDRSLCERVVPG 255

Human   261 NRVTIMGIYSIKKFGLTTSR-GRDRVGVGIRSSYIRVLGIQVDTDGSGR-SFAGAVSPQEEEEFR 323
            |||.|.|||||:|.|..:.| ||::..||:|:.|:||:||.||::|:|. |....::..|||.||
  Fly   256 NRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFR 320

Human   324 RLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKS 388
            |:||..::||.:|:|:||||||..|:||||.|:|||||||||||||.||||||:|:|||||||||
  Fly   321 RMAASGDIYERLSQSLAPSIFGSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKS 385

Human   389 QLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMRED 453
            ||||||||.:||.||||||||||||||||||:||.:|||:|||||||||||||||||||||||||
  Fly   386 QLLKFVEKVAPIAVYTSGKGSSAAGLTASVMKDPQTRNFVMEGGAMVLADGGVVCIDEFDKMRED 450

Human   454 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIF 518
            |||||||||||||||||||||||||||||||||||||:|||||:||||:||||||||||||||||
  Fly   451 DRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSIFGRWDDTKGEENIDFMPTILSRFDMIF 515

Human   519 IVKDEHNEERDVMLAKHVITLHVSA--LTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEK 581
            ||||.|:|.||:.||||:|.:|:|:  ...::..||||.|:..||:|.|||..||||||..|.||
  Fly   516 IVKDIHDESRDITLAKHIINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAGEK 580

Human   582 LKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQV 646
            ||:||::|||||.|.|:.||:|.|||||||||||::||:|:|:|::||||||:..|.||||||||
  Fly   581 LKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKIRLQPFATDEHVNEALRLFQV 645

Human   647 STLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKV 711
            ||||||::|:|:|.||||::||||.|:||||||||||||||||||.:|::||.:|||.|..:.||
  Fly   646 STLDAAMTGSLAGAEGFTTEEDQETLNRIEKQLKRRFAIGSQVSEQNILQDFLRQKYEERTVMKV 710

Human   712 LQLMLRRGEIQHRMQRKVLYRL 733
            :..|:||||:|||||||:|||:
  Fly   711 IHTMIRRGELQHRMQRKMLYRI 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	53/97 (55%)
		MCM	133..649	CDD:214631	376/519 (72%)
Mcm5	NP_524308.2	MCM_N	31..125	CDD:464206	53/97 (55%)
		MCM	128..648	CDD:214631	376/519 (72%)