Protein Alignment MCM5 and Mcm2

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_477121.1
• Gene: Mcm2 / 40973
• FlyBaseID: FBgn0014861
• Length: 887
• Species: Drosophila melanogaster
• Alignment Length: 679
• Identity: 227/679 - (33%)
• Similarity: 364/679 - (53%)
• Gaps: 66/679 - (9%)

Human    28 KSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKR--HYNLGEYWIEVEMEDLASFDEDLADYLYK 90
            ::::..||:.|||.:   .|..| .:.|||.::|  ..|:..:  .|...|||:.:..||.:|.:
  Fly   177 RTEIANRFQSFLRTF---VDERG-AYTYRDRIRRMCEQNMSSF--VVSYTDLANKEHVLAYFLPE 235

Human    91 QPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGII 155
            .|.:.|::.::.||   |.|....|:.|.|..:|.|.:........:|:.:...::.||:..|::
  Fly   236 APFQMLEIFDKVAK---DMVLSIFPTYERVTTEIHVRISELPLIEELRTFRKLHLNQLVRTLGVV 297

Human   156 IAASAVRAKATRISIQCRSCRNTL------TNIAMRPGLEGYALPRKCNTDQAGRPKC-PLDPYF 213
            .|.:.|..:.:.|...|..|...|      .|..::||        .|       |:| ...|:.
  Fly   298 TATTGVLPQLSVIKYDCVKCGYVLGPFVQSQNTEIKPG--------SC-------PECQSTGPFS 347

Human   214 IMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFG-LT 277
            |..::....::|.:.|||.|..:|.|.:||...:.....|||:..||:.:.:.|||:....| |.
  Fly   348 INMEQTLYRNYQKITLQESPGRIPAGRIPRSKDVILLADLCDQCKPGDELEVTGIYTNNYDGSLN 412

Human   278 TSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPS 342
            |.:|.......|.::::.|        ...:....:::.::....::|:..|.:.|.:..|:|||
  Fly   413 TDQGFPVFATVIIANHVVV--------KDSKQVVQSLTDEDIATIQKLSKDPRIVERVVASMAPS 469

Human   343 IFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGK 407
            |:|...:|:|:|..||||..|...:....|||||||:.|||||||||.||:.||.:|..|:|:|:
  Fly   470 IYGHDYIKRALALALFGGESKNPGEKHKVRGDINLLICGDPGTAKSQFLKYTEKVAPRAVFTTGQ 534

Human   408 GSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKA 472
            |:||.||||.|.|:|.||.:.:|.||:||||.||..|||||||.:.||.:||||||||:|||:||
  Fly   535 GASAVGLTAYVRRNPVSREWTLEAGALVLADQGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKA 599

Human   473 GITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHV 536
            ||.|:|.:||:|:||||.:.||:|.:.. .:|::....||||||::.:||||.:..:|..|||.|
  Fly   600 GIVTSLQARCTVIAAANPIGGRYDPSMTFSENVNLSEPILSRFDVLCVVKDEFDPMQDQQLAKFV 664

Human   537 ITLHV----SALTQTQAVE------GEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRS 591
            :..|:    |...|.:..|      .||....|:::|.|.:....|:|:....:|:...|..:|
  Fly   665 VHSHMKHHPSEEEQPELEEPQLKTVDEIPQDLLRQYIVYAKENIRPKLTNIDEDKIAKMYAQLR- 728

Human   592 GARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGT 656
                  ::|....|:|||||.:|:::|::||.::|.|:....||||..|:|:...|.::|.....
  Fly   729 ------QESFATGSLPITVRHIESVIRMSEAHARMHLRENVMEADVSMAIRMMLESFIEAQKFSV 787

Human   657 LSGVEG-----FTSQED-QEMLSRIEKQL 679
            :..:..     .:.|:| .|:|..|.:||
  Fly   788 MKKMRSTFQKYLSFQKDHSELLFFILRQL 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	30/99 (30%)
		MCM	133..649	CDD:214631	189/534 (35%)
Mcm2	NP_477121.1	MCM2_N	59..166	CDD:403724
		MCM_N	182..271	CDD:464206	30/97 (31%)
		MCM	276..780	CDD:214631	189/533 (35%)