Protein Alignment MCM5 and Mcm7

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_523984.1
• Gene: Mcm7 / 39014
• FlyBaseID: FBgn0020633
• Length: 720
• Species: Drosophila melanogaster
• Alignment Length: 754
• Identity: 231/754 - (30%)
• Similarity: 374/754 - (49%)
• Gaps: 116/754 - (15%)

Human    19 AQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDED 83
            |:.|..|.|:|     .|.||.::....|.....|.|..:|.:..:..:..|.::::|||.|:|.
  Fly     2 ARRDYAQDRES-----IKTFLSEFCKCDDDGKKEFVYGSQLVKLAHREQVLITIDLDDLAEFNES 61

Human    84 LADYL---------------------YKQP-----------AEHLQLLEEAAKEVADEVTRPRPS 116
            ||:.:                     |||.           .||..::|...:...::.......
  Fly    62 LAEAVVDNCRRYTSIFSDVIAELLPSYKQQEVHAKDALDVYIEHRLMMESRTRNPMEQRDERNSF 126

Human   117 GEEVLQDIQVMLK--SDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRN-- 177
            ..|:::..:|..|  |.....|||.:|:..:..||.:.||:...:.|:......:..|..|.:
  Fly   127 PSELMKRFEVGFKPLSTEKAHSIREVKAQHIGKLVTVRGIVTRCTEVKPMMVVATYTCDRCGSET 191

Human   178 --TLTNIAMRPGLEGYALPR-KCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHG 239
              .:.:::..|   .:..|. .|..::||      ...::.....|.|.||.:|:||..|.||.|
  Fly   192 YQPVNSLSFTP---VHDCPSDDCRVNKAG------GRLYLQTRGSKFVKFQEVKMQEHSDQVPVG 247

Human   240 EMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSR-GRDRVGVGIRSSYI----RVLGI 299
            .:||.|.:.|...:.....||:.:.:.|::      |...| |..::..|:.|...    |::.|
  Fly   248 HIPRSMTIMCRGEVTRMAQPGDHIVVSGVF------LPLMRTGFAQMIQGLLSETFLQAHRIICI 306

Human   300 QVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKR 364
            ..:.:.|.:.  ..::|:|.||.    |..:.||.::.|:||.|:|..|:|||:..||.||..||
  Fly   307 NKNDEISDKD--AELTPEELEEL----AQDDFYERLATSLAPEIYGHLDVKKALLLLLVGGVDKR 365

Human   365 LPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIM 429
             |||:..||:||:.::||||.||||||.::.:.:....||:|:|||..||||:||:||.:....:
  Fly   366 -PDGMKIRGNINICLMGDPGVAKSQLLGYISRLAVRSQYTTGRGSSGVGLTAAVMKDPLTGEMTL 429

Human   430 EGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGR 494
            ||||:||||.||.||||||||.:.||.||||.|||||||||||||.||||:|.|:|||||..|||
  Fly   430 EGGALVLADQGVCCIDEFDKMADQDRTAIHEVMEQQTISIAKAGIMTTLNARVSILAAANPAFGR 494

Human   495 WDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAK 558
            ::..:. |.||.....:|||||::::::|:.:.:.|:.||||:..:|..:......|:. :|:..
  Fly   495 YNPRRTVEQNIQLPAALLSRFDLLWLIQDKPDRDNDLRLAKHITYVHSHSKQPPTRVKA-LDMNL 558

Human   559 LKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEAL 623
            ::::|..|:.| .|.:..|..:.:...|:.:|..|| :::|....|:     |.|..|:|::.||
  Fly   559 MRRYINLCKRK-NPTIPDELTDYIVGAYVELRREAR-NQKDMTFTSA-----RNLLGILRLSTAL 616

Human   624 SKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLK-------- 680
            ::::|.....:.||.|||||.::|                     ::.|::|.:..|
  Fly   617 ARLRLSDSVEKDDVAEALRLLEMS---------------------KDSLNQIHEHQKGHVPNTSD 660

Human   681 RRFAI-------GSQVSEHSIIKDFTKQKYPEHAIHKVL 712
            |.|||       |..|....|:...|.:.:....:.|.:
  Fly   661 RIFAIVRELAGSGKAVKISDIMDRCTTKGFKPDQVDKCI 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	24/131 (18%)
		MCM	133..649	CDD:214631	189/526 (36%)
Mcm7	NP_523984.1	MCM_N	10..103	CDD:464206	20/97 (21%)
		MCM	145..641	CDD:475121	189/546 (35%)