Protein Alignment MCM5 and dpa

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_477185.1
• Gene: dpa / 35679
• FlyBaseID: FBgn0015929
• Length: 866
• Species: Drosophila melanogaster
• Alignment Length: 735
• Identity: 242/735 - (32%)
• Similarity: 379/735 - (51%)
• Gaps: 96/735 - (13%)

Human    29 SQLQRRFKEFLRQY------------RVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFD 81
            ||.:.:||.|:.::            .:..::.    .|..:|:..:.|.|.::.:....|.:||
  Fly   162 SQCKSKFKSFIMRFIDPSAEQDEISENIDVNQP----LYLQKLEEIHTLEEPYLNLNCAHLKTFD 222

Human    82 EDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMS 146
            :||...|...|.|.:...:.|..|:..|    |.....:...|||...:.....::|||..:.|.
  Fly   223 QDLYRQLICYPQEVIPGFDMAINEMFFE----RYPAALLEHQIQVRPFNADKTRNMRSLNPEDMD 283

Human   147 HLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDP 211
            .|:.|.|::|.:|.|..:.......|..|..:.|....|..:....|...|||:...|
  Fly   284 QLISISGMVIRSSNVIPEMREAFFSCNICSFSTTVEVDRGRINQPTLCTNCNTNHCFR------- 341

Human   212 YFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIY---SIKK 273
              ::.::.:..|.|.:||||.||.:..|:.|.::.||....|.|||.||:|||:.|||   .:|.
  Fly   342 --LIHNRSEFTDKQLVKLQESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKT 404

Human   274 FGLTTSRGRDRVGVGIRSSY---IRVL--------GIQVDTDGSGRSFAGAVSPQEEEEFRRLAA 327
            .||::|         ::|.|   :.|:        .:..|.:|....|    .|:..|..:.||.
  Fly   405 GGLSSS---------VKSVYKTHVDVVHFRKVDNKRLYEDEEGKDHIF----PPERVELLQLLAK 456

Human   328 LPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTR---RGDINLLMLGDPGTAKSQ 389
            .|::|:.::::|||||:...|:||.|...||||::|:... |.|   |.:|:||:.|||||:|||
  Fly   457 KPDIYDRLARAIAPSIYENDDIKKGILLQLFGGTKKKHAT-LGRQNFRSEIHLLLCGDPGTSKSQ 520

Human   390 LLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDD 454
            :|::|....|...||||:||||.||||.|.:||.:|..:::.||:||||.||.||||||||.:..
  Fly   521 MLQYVFNLVPRSQYTSGRGSSAVGLTAYVTKDPETRQLVLQTGALVLADNGVCCIDEFDKMNDST 585

Human   455 RVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKG-EDNIDFMPTILSRFDMIF 518
            |..:||.|||||:|||||||...||:|.|:|||||....:|::.|. .||:....|:|||||:||
  Fly   586 RSVLHEVMEQQTLSIAKAGIICQLNARTSILAAANPAESQWNKRKNIIDNVQLPHTLLSRFDLIF 650

Human   519 IVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLK 583
            :|.|..:|..|..||.|:::|:.  :|:.:..:...|::.|:.:|||.|....|.||.||.::|.
  Fly   651 LVLDPQDEIFDKRLASHLVSLYY--VTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAQQRLI 713

Human   584 NRYIIMRS-GARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS 647
            ..|:.||. ||        .|..|....||||:::|::||.:|::|.......|||||.||.:.:
  Fly   714 QAYVDMRKVGA--------GRGQISAYPRQLESLIRLSEAHAKVRLSNQVELLDVEEAWRLHREA 770

Human   648 TLDAA---LSGTL------SGVEGFTSQEDQEMLSRIEKQLKRRFAI--------------GSQV 689
            ...:|   |||.:      :|:.....::..::::.|::.||::..:              |||:
  Fly   771 LKQSATDPLSGKIDVGILTTGLSTAARKKRADLVAAIKENLKKKGKVLTVPYQKLFSDIKEGSQI 835

Human   690 S-EHSIIKDFTKQKYPEHAI 708
            . .....:|..|:...|.||
  Fly   836 MITREQFEDALKEVQDEGAI 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	22/109 (20%)
		MCM	133..649	CDD:214631	202/534 (38%)
dpa	NP_477185.1	PHA03307	2..>150	CDD:223039
		MCM_N	165..267	CDD:464206	22/109 (20%)
		MCM	270..772	CDD:214631	202/534 (38%)