Protein Alignment MCM5 and Mcm6

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_511065.1
• Gene: Mcm6 / 31603
• FlyBaseID: FBgn0025815
• Length: 817
• Species: Drosophila melanogaster
• Alignment Length: 677
• Identity: 213/677 - (31%)
• Similarity: 339/677 - (50%)
• Gaps: 77/677 - (11%)

Human    19 AQADEGQAR-KSQL----QRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLA 78
            |.|..||.| |.::    |:.|::||.:::...:     .||........:.....:||..||:.
  Fly     4 ADAQVGQLRVKDEVGIRAQKLFQDFLEEFKEDGE-----IKYTRPAASLESPDRCTLEVSFEDVE 63

Human    79 SFDEDLA-----DYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIR 138
            .:|::||     :|.:..|.    |.:..:..|.|.:      |.:..:|..|......:...:|
  Fly    64 KYDQNLATAIIEEYYHIYPF----LCQSVSNYVKDRI------GLKTQKDCYVAFTEVPTRHKVR 118

Human   139 SLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAG 203
            .|.:..:..|::|.|.::....|..:.......|..|:..:.|:..:   ..:..|..|.
  Fly   119 DLTTSKIGTLIRISGQVVRTHPVHPELVSGVFMCLDCQTEIRNVEQQ---FKFTNPTICR----- 175

Human   204 RPKCPLDPYFIMP-DKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMG 267
            .|.|.....|::. :|...:|||.:::||....:|.|.:||.:::.....|.:.|..|:|....|
  Fly   176 NPVCSNRKRFMLDVEKSLFLDFQKIRIQETQAELPRGCIPRAVEIILRSELVETVQAGDRYDFTG 240

Human   268 IYSIKK-----FGLTT----------SRGRDRV----GVGIRSSYIRVLGIQVDTDGSGRSFAGA 313
            ...:..     .|:.|          ..|.|.|    .:|:|....|:..:......:...|.|.
  Fly   241 TLIVVPDVSVLAGVGTRAENSSRHKPGEGMDGVTGLKALGMRELNYRMAFLACSVQATTARFGGT 305

Human   314 VSPQEE---EEFRR------------LAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRK 363
            ..|..|   |:.::            ::...|:|:.:..|:.|||:|..::|:.|....|||..|
  Fly   306 DLPMSEVTAEDMKKQMTDAEWHKIYEMSKDRNLYQNLISSLFPSIYGNDEVKRGILLQQFGGVAK 370

Human   364 RLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFI 428
            ...:..:.|||||:.::|||.|||||.||.|...||..:|||||.||||||||:|:||..|.:|:
  Fly   371 TTTEKTSLRGDINVCIVGDPSTAKSQFLKQVSDFSPRAIYTSGKASSAAGLTAAVVRDEESFDFV 435

Human   429 MEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFG 493
            :|.||::|||.|:.||||||||.:.|:|||||||||||||||:||:..|||:|.|:|||||.:.|
  Fly   436 IEAGALMLADNGICCIDEFDKMDQRDQVAIHEAMEQQTISIARAGVRATLNARTSILAAANPING 500

Human   494 RWDETKG-EDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLA 557
            |:|.:|. :.||.....|:||||:.||:.||.||..|..:|:.::.||.:.   .::||......
  Fly   501 RYDRSKSLQQNIQLSAPIMSRFDLFFILVDECNEVVDYAIARKIVDLHSNI---EESVERAYTRE 562

Human   558 KLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEA 622
            ::.:::.:.| :..|.:|.||...|...|    ...||.:..:..||:..|||||||:::|::||
  Fly   563 EVLRYVTFAR-QFKPVISQEAGHMLVENY----GHLRQRDTGTSGRSTWRITVRQLESMIRLSEA 622

Human   623 LSKMKLQPFATEADVEEALRLFQVSTL 649
            ::|::......|..|:||.||...|.:
  Fly   623 MAKLECSNRVLERHVKEAFRLLNKSII 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	21/102 (21%)
		MCM	133..649	CDD:214631	186/551 (34%)
Mcm6	NP_511065.1	MCM_N	22..109	CDD:464206	21/101 (21%)
		MCM	113..649	CDD:475121	186/551 (34%)
		MCM6_C	702..816	CDD:465688