Protein Alignment MCM5 and Mcm3

DIOPT Version :10

• Sequence 1: NP_006730.2
• Gene: MCM5 / 4174
• HGNCID: 6948
• Length: 734
• Species: Homo sapiens
• Sequence 2: NP_511048.2
• Gene: Mcm3 / 31449
• FlyBaseID: FBgn0284442
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 826
• Identity: 250/826 - (30%)
• Similarity: 379/826 - (45%)
• Gaps: 174/826 - (21%)

Human    21 ADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDEL----KRHYNLGEYWIEVEMEDLASFD 81
            |.||:.....:||.:.:||....   |:..:....:|.:    ||        :.|.:.||..
  Fly     2 AHEGEQFIKDIQREYVDFLDDEE---DQGIYAGHVKDMIAEKSKR--------LIVNVNDLKR-- 53

Human    82 EDLADYLYKQPAEHLQLLEEAA----------KEVADEVTRPRPSGEEVLQDIQVMLKS-----D 131
                    |.|...|.||..||          ||.|..|.   |...::.:|:.|..:.     .
  Fly    54 --------KNPQRALGLLSNAADEQLAFGRALKEYASTVD---PGYAKMHEDLFVGFEGCFGNRH 107

Human   132 ASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNT-------LTNIAMRPGLE 189
            .:|   |||.|..:.::|.:.||:...|.:|.|..|....|.:.|..       ||:....|  .
  Fly   108 VTP---RSLTSIYLGNMVCVEGIVTKVSLIRPKVVRSVHYCPNTRKVMERKYTDLTSFEAVP--S 167

Human   190 GYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLC 254
            |.|.|.|.........:..|..|         .|.|||.:||:|:..|.|::||.:.:.||..|.
  Fly   168 GAAYPTKDEDGNLLETEYGLSVY---------KDHQTLTIQEMPEKAPAGQLPRSVDIVCDDDLV 223

Human   255 DKVVPGNRVTIMGIYSI---KKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSP 316
            |:..||:||.|:|.|..   |:.|.|:...|    ..:.::.|.:|..:.:.|         :|.
  Fly   224 DRCKPGDRVQIVGSYRCLPGKRGGYTSGTFR----TVLLANNISLLSKESNLD---------ISR 275

Human   317 QEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLG 381
            ::....::||...:::|::|||:||||.|...:|:||.|||.||..|.||:|...|||||:|::|
  Fly   276 EDIMLCKKLAKNNDIFELLSKSLAPSIHGHAYVKQAILCLLLGGVEKILPNGTRLRGDINVLLIG 340

Human   382 DPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDE 446
            ||..||||||::|...:|..:.|:|:|||..||||:|..|..:....:|.|||||||.|||||||
  Fly   341 DPSVAKSQLLRYVLNTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDE 405

Human   447 FDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGE-DNIDFMPTI 510
            ||||.:.||.||||.|||..::|:||||..:||:|||||||||.|:||:|:.|.. :||....::
  Fly   406 FDKMSDIDRTAIHEVMEQGRVTISKAGIHASLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSL 470

Human   511 LSRFDMIFIVKDEHNEERDVMLAKHVITLH-------------------VSALTQTQAVEGEIDL 556
            |||||::|::.|..:.:.|.|::.||:.:|                   ..:|:...:.|.:.|.
  Fly   471 LSRFDLLFVMLDVIDSDVDQMISDHVVRMHRYRNPKEADGEPLSMGSSYADSLSFVSSSEEKKDT 535

Human   557 AKLKKFIA---------------------YCRV-KC-GPRLSAEAAEKLKNRYIIMRSGARQHER 598
            ...:|:.|                     |..: || .|:|..:|.|.:.|.|..:||   |...
  Fly   536 EVYEKYDALLHGKSRQRHEKILSVEFMRKYIHIAKCMKPKLGEQACEAIANEYSRLRS---QEAV 597

Human   599 DSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVS----TLDAALSGTLSG 659
            ::|...:.|||.|.||.::|::.|.::.::....|..|...|:.|.|.:    .||.........
  Fly   598 ETDVARTQPITARTLETLIRLSTAHARARMSKSVTIDDAHAAIELVQFAYFKKVLDKDRPSKRRR 662

Human   660 VEGFTSQED------QEMLSRIEKQLKRRFAIGSQVSEHSI----------IKDFTKQKYPEHAI 708
            ..|..:::|      |...||..|: .|...:|:...|..|          .:..|::..|..:
  Fly   663 NSGSDAEDDNGEASSQRSPSRRSKR-TRTATVGADSDEEDIEPPQPDAGDLTRRETRRSLPARS- 725

Human   709 HKVLQLM----------------------LRRGEIQHRMQRKVLYR 732
              |..||                      .|.||.::.:||  |:|
  Fly   726 --VAMLMASPSSEEQSVATSTTEPAIISDARLGEFKNNLQR--LFR 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MCM5	NP_006730.2	MCM_N	32..130	CDD:464206	25/111 (23%)
		MCM	133..649	CDD:214631	198/572 (35%)
Mcm3	NP_511048.2	MCM_N	13..101	CDD:464206	25/111 (23%)
		MCM	106..648	CDD:214631	198/571 (35%)