Protein Alignment IFT54 and TRAF3IP1

DIOPT Version :10

• Sequence 1: NP_650353.1
• Gene: IFT54 / 41739
• FlyBaseID: FBgn0038221
• Length: 588
• Species: Drosophila melanogaster
• Sequence 2: XP_011509246.1
• Gene: TRAF3IP1 / 26146
• HGNCID: 17861
• Length: 725
• Species: Homo sapiens
• Alignment Length: 730
• Identity: 199/730 - (27%)
• Similarity: 314/730 - (43%)
• Gaps: 169/730 - (23%)

  Fly     8 AIILETQKVLGKYIKKPPLTEKLLKKPPFRFLMDVFSNFIKQSGTFDGLYTPEEQMFENITSRED 72
            |::..||:.|||.|::||||||||.|||||:|.|:.:..|:.:|...||||..|...:|:..::.
Human     4 AVVRRTQEALGKVIRRPPLTEKLLSKPPFRYLHDIITEVIRMTGFMKGLYTDAEMKSDNVKDKDA 68

  Fly    73 KIRFLQKMIDATKLTTKLDLKVRTSKIVAGQEPELTNELLQAMASVAEKNLEWDSIVDQVVISHS 137
            ||.||||.||...:.:...|..:.::||||.|||.||||||.:.......|..|..|.:|:....
Human    69 KISFLQKAIDVVVMVSGEPLLAKPARIVAGHEPERTNELLQIIGKCCLNKLSSDDAVRRVLAGEK 133

  Fly   138 ---KTPLTLTKPPKETKNSS---------KNPSPAGKDEDAKRRKEKRISPQEQKLR-------- 182
               |...:||...:|..|.:         ||....| |.:.|.|...|...|:::|:
Human   134 GEVKGRASLTSRSQELDNKNVREEESRVHKNTEDRG-DAEIKERSTSRDRKQKEELKEDRKPREK 197

  Fly   183 -----KVKEQ-------------VSRSTP---------------PTEKDKASQKKSKAPKDETKL 214
                 |.||.             .:|:.|               .:|:.|.:::||:..|::.:|
Human   198 DKDKEKAKENGGNRHREGERERAKARARPDNERQKDRGNRERDRDSERKKETERKSEGGKEKERL 262

  Fly   215 ---------------------------------SRQNSKQKSPSPVKQKSKAKLQPSTESDNLSQ 246
                                             :|::.|.:..|....:...||...|..|:.::
Human   263 RDRDRERDRDKGKDRDRRRVKNGEHSWDLDREKNREHDKPEKKSASSGEMSKKLSDGTFKDSKAE 327

  Fly   247 SMSPVE--------------------EGSTKPAASESAPSKPEPE------------MVPPLKEK 279
            :.:.:.                    ||...|..||::.| ||.|            .:..|..|
Human   328 TETEISTRASKSLTTKTSKRRSKNSVEGRRDPKTSENSLS-PEKEHNFSYCKAKKEHSMKQLGRK 391

  Fly   280 E---------AVV-----RPVQETPTAPPAEPESR-KSSSRSRRSSGSHRQPEPNPIPNESQSQP 329
            |         ::|     .|.|||.|:.....|:. .|:|.|..:|.|.|.....|.|.|.|...
Human   392 EDNISAKSLDSIVSGINNEPNQETTTSEIGTKEANINSTSISDDNSASLRCENIQPNPTEKQKGD 456

  Fly   330 AVQSSETSSPPETNSGEAKREVPLTRENSKEVNQRPRTSLRPPSARPASARPGAPRRRNVEIVLQ 394
            :...:|..:.|   :|:.|.|||.|.|...|::...|...||.|||||.  |...|:.::|.:
Human   457 STSDAEGDAGP---AGQDKSEVPETPEIPNELSSNIRRIPRPGSARPAP--PRVKRQDSMEAL-- 514

  Fly   395 PNDQIKMSG-----INVKLETFGDLDDDGENLVIIEDSAAHDIVEGGGDEPALEGQLDAQ---GR 451
               |:..||     .||..|:....:::.:..|:   .||..:.|....|.....:|:.:   |.
Human   515 ---QMDRSGSGKTVSNVITESHNSDNEEDDQFVV---EAAPQLSEMSEIEMVTAVELEEEEKHGG 573

  Fly   452 LVQQILETQKELVNQGAEVEPPPAQAGR-----------QTSARQVNDVRDVVQKLTKSIGPLGK 505
            ||::||||:|:.  :..:..|.|.:..|           ...::::..:|..:|.|.||..||||
Human   574 LVKKILETKKDY--EKLQQSPKPGEKERSLFESAWKKEKDIVSKEIEKLRTSIQTLCKSALPLGK 636

  Fly   506 LLDCIPEDFDAMQLELTMWRDTYTQASTELKREQTLTASATEPLQHQLQQIQASIAEYRELIDES 570
            ::|.|.||.||||.||.||.....|.:..|::||.:|..|.|||:.:|.:::..|.:.::.|...
Human   637 IMDYIQEDVDAMQNELQMWHSENRQHAEALQQEQRITDCAVEPLKAELAELEQLIKDQQDKICAV 701

  Fly   571 RHKILQNNARILKLM 585
            :..||:|..:|.|::
Human   702 KANILKNEEKIQKMV 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IFT54	NP_650353.1	MIP-T3	9..119	CDD:463020	51/109 (47%)
		PHA03247	<146..395	CDD:223021	79/378 (21%)
		MIP-T3_C	444..588	CDD:465481	50/156 (32%)
TRAF3IP1	XP_011509246.1	MIP-T3	5..117	CDD:463020	51/111 (46%)
		PTZ00121	<100..621	CDD:173412	118/537 (22%)
		PRK12678	<132..>300	CDD:237171	26/168 (15%)
		MIP-T3_C	566..719	CDD:465481	49/153 (32%)