Fly 80 ASSSAGSGNSGNGSSSGSSTG-SGSSGSGSTNGGSVNGGTHHKSAANLDKEAVTKDQNGDGDKTR 143
|:::.|....|.||:.|...| ...:|.|...||..||....:.|.. |
Human 2 AAAAGGGSCPGPGSARGRFPGRPRGAGGGGGRGGRGNGAERVRVALR-----------------R 49
Fly 144 GNVSSAPSGK--------LSAAASGKALSKSSRTFSASTSVTSSGRSSGSSPDGNSGA-----SS 195
|..::.|.|. |......:.|.:..|.::........||..|.....:.|. ||
Human 50 GGGATGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGPRVQRGRGRGRGRGWGPSRGCVPEEESS 114
Fly 196 DGAS-----SGISCGKSTAKSTEASS------------GKLAKTTG---------AGTCSSAKSS 234
||.| .|....:..|.|:..|: |:..|||. |.|.....:.
Human 115 DGESDEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPPRLADVAPTPPKTPAR 179
Fly 235 K-ASSGT------------TSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPI 286
| ...|| .::|..:..|.||.. :||..|.| .|.|...|
Human 180 KRGEEGTERMVQALTELLRRAQAPQAPRSRACEP----STPRRSRG------RPPGRPAG----- 229
Fly 287 SAALLRARKNSNKKFKNLNLARGEVMLPSTSKLKQLNSPVVDNPSPSPPIA-----SGSTPSVEG 346
...:|.:.:.:|...|.:| .|.|.||:. :||....||
Human 230 ---------PCRRKQQAVVVAEAAVTIP--------------KPEPPPPVVPVKHQTGSWKCKEG 271
Fly 347 GIGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSS 411
|| |.|.:.......:..|:|....|
Human 272 ---------PG-------------------PGPGTPRRGGQSSRGGRGGRGRG------------ 296
Fly 412 PKSGADTGPSTSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYS 476
Human 297 ----------------------------------------------------------------- 296
Fly 477 RGGECIVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDD 541
|||.. |.:: |.:::...: |:..|. .||....|....|:.
Human 297 RGGGL---PFVI-KFVSRAKKV-KMGQLS---------------------LGLESGQGQGQHEES 335
Fly 542 EGGVTFRRNDSPEDQN---NAEDDEMDDDDDD--EEAEEDDENEDDNDEAVSEKSAETEKSAGAD 601
...|..||..|.:..: ..::.::||:::: ||.|:|.|.|:..:.||:|:
Human 336 WQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEE----------- 389
Fly 602 ERDPDEKQLVMDSHFVLPKRSTRSSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAG 666
::|......:::..|. |...|.|...||.
Human 390 ---------------MMPAAEKEEAKLPPPP---LTPPAPSPPPPLP------------------ 418
Fly 667 STASTFSASTNLKLGKETFFNFGTLKPNSSAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSA 731
.|::|. .|.| ..|...|.||..
Human 419 -------------------------PPSTSP-------PPPL-----------CPPPPPPVSPPP 440
Fly 732 IPKPANSLATSSFGSLASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMT 796
:|.|....| ......:|.|...:.||.......:|.::: ..:..::..
Human 441 LPSPPPPPA---------QEEQEESPPPVVPATCSRKRGRPPLTPSQR--------AEREAARAG 488
Fly 797 KKSISANSSTANTSSGSQQYLQCKGNEGSPCSIHSAKSQLKNFKKFYKDRCTA-----CWLKKCM 856
.:..|..:.|.:|::|... |.||.....:.:.|||.::|.....:| ....:..
Human 489 PEGTSPPTPTPSTATGGPP-------EDSPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRF 546
Fly 857 ISFQLPAAHRSRLSAILPPGMRGEAAAREEKSAELLSPTGSLRFTSTASSSSP------SVVAST 915
:....|...:..:|.:|.|.:.......:| .|.:.||. |..:..|:..| |::...
Human 547 MDEDPPKPPKVEVSPVLRPPITTSPPVPQE-PAPVPSPP---RAPTPPSTPVPLPEKRRSILREP 607
Fly 916 SVKWKSSGDSTSALTSIKPNPLAENNVTFGSTPLLRPAILENPLF------LKI--SNAADQKLA 972
:.:|.|............|.|.|.:.....:|...||.:|..|.| ||| |......|.
Human 608 TFRWTSLTRELPPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLG 672
Fly 973 AAEAISPSLTKKNSKQEKEKVKESEQSEKL---------LSPTQAGTKKSGA------AEAQVEE 1022
|.||..|.....:....:.:.:...::..| .:|.:|.....|| .:.|.:.
Human 673 APEAPEPEPPPADDSPAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQL 737
Fly 1023 VQP----QKEEAPQTSTTTQP-------------------------------------------- 1039
:|| |.:..||.....||
Human 738 LQPLQALQTQLLPQALPPPQPQLQPPPSPQQMPPLEKARIAGVGSLPLSGVEEKMFSLLKRAKVQ 802
Fly 1040 ------------SASNGASHGVPQAELAGETNATGD-----------TLKRQR-----IDLKGPR 1076
:||...|.|....|:||......| ..||:| ..::|||
Human 803 LFKIDQQQQQKVAASMPLSPGGQMEEVAGAVKQISDRGPVRSEDESVEAKRERPSGPESPVQGPR 867
Fly 1077 VKHVCRSASIVLGQPLATFGED-----------------QQPEDAADMQQ--------EIAAPVP 1116
:|||||.|::.|||..|...|| :....|::.:. ::.|..|
Human 868 IKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSRRGKVEAAGP 932
Fly 1117 SAIMEP---------SPEK--PTH----------------IVTDENDNCASCKTSPV--GDESKP 1152
....|| :|.: |:| :...:..:|.:|...|. |..:|.
Human 933 GGESEPTGSGGTLAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKK 997
Fly 1153 S-----KSSGSAQAEVKKATALGKEG--------------------------TASAAGGSSAKVT 1186
. |.. :.|.:|...|.|:| ..:.|||...:|.
Human 998 QCCVYRKCD---KIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGPREEVV 1059
Fly 1187 TRNAAVASNLIVAASK-----KQR-NGDIATSSS---------------------VTQSSNQTQG 1224
........:.::.... ||| :.||...|. :.:...|::.
Human 1060 AHPGPEEQDSLLQRKSARRCVKQRPSYDIFEDSDDSEPGGPPAPRRRTPRENELPLPEPEEQSRP 1124
Fly 1225 RK-----TKEHRQQRTL-----------------------------ISIDFWENYDPAEVCQTGF 1255
|| ..:.:.:|.| :.:||.|:.|...|...|
Human 1125 RKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMG- 1188
Fly 1256 GLIVTETV--AQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQD-EYNL-KHGSFEDTTLMGSLL 1316
||.|..:| ....:|.||.|.||..|:||..||:|:|.:|::: |..| :| .||
Human 1189 GLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQH---HDT------- 1243
Fly 1317 ETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSS-GSK--VKCQKCQKNYHSTCLGTS--K 1376
|.|.||..|:.|.... ||| ::|::|:..||..|||.| .
Human 1244 ----------------------WCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPT 1286
Fly 1377 RLLGADRPLICVNCLKCKSCSTTKVS----KFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFD 1437
|.....|..||..|::||||..|... ::.|:..:|..|.:|.:|||:||||.|||:|||::
Human 1287 RATRKRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYE 1351
Fly 1438 LKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEEFK 1502
.|||:|..|..|||:||||||||.|.:||.||:|:.:.|..||...: ..||:|:....:
Human 1352 SKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGAAQ------PRWREALSGALQ 1410
Fly 1503 ASLYSVLKLLSKSRQACALLKLSPRKKLRCT-CGASSNQGKLQPKALQFSSGSDNGLGSDGESQN 1566
..|..||:.|..|:....| |.|| || |...|...|
Human 1411 GGLRQVLQGLLSSKVVGPL--------LLCTQCG---------PDGKQLHPG------------- 1445
Fly 1567 SDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNY 1631
||..|. :.|:.....|.|:..|..
Human 1446 -----------------------------PCGLQA------------VSQRFEDGHYKSVHSFME 1469
Fly 1632 DMSQVIQQSNCD----------ELDIAYKELLSEQFPWF--------QNETKACTDALEEDMFES 1678
||..::.:.:.: ::.....:||...|.|| :..|:.....|...:...
Human 1470 DMVGILMRHSEEGETPDRRAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVLPNAVLPP 1534
Fly 1679 CSGGNY-----------EDLQDTGGVSASVYNEHSTSQAESRSGVLDIPLEEVDDFGSCGIKMRL 1732
.....| |..|..|..||:...:...:.:. ||
Human 1535 SLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSH---------LE-------------- 1576
Fly 1733 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKC 1797
|.|.|..|.|.|:..|.|..||||.|.:.|.|.|||:||||||||.||||:|||:||||||.::|
Human 1577 DPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRC 1641
Fly 1798 TVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAK--NGNALKANGSPSVTYES 1860
.:|...||||||.:.||..::|:.|||:..|.|..||.::|..|.. :|. .:....
Human 1642 ELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGK--------EIVNPD 1698
Fly 1861 NFEVSRPVYVE---LDRKRKKL--IEPARVQFHIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSR 1920
.|:|.|.|||: ::.|||.| :||..:...|||:.:..||.: ...||....:.||.:.|||
Human 1699 GFDVLRRVYVDFEGINFKRKFLTGLEPDAINVLIGSIRIDSLGTL-SDLSDCEGRLFPIGYQCSR 1762
Fly 1921 LYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARS 1985
|||| ||| |:...|: |.
Human 1763 LYWS--------------------------------TVD-------------ARRRCWY----RC 1778
Fly 1986 EFLENGGTDWSGEFPNPNSCVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFL 2050
..||. ..| ...||| |.|
Human 1779 RILEY--RPW---------------GPREEP---AHL---------------------------- 1795
Fly 2051 YDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPASNPV-- 2113
:|..:|| |.:.:..|:|.|.
Human 1796 ------------------------EAAEENQ-------------------TIVHSPAPSSEPPGG 1817
Fly 2114 EDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATV 2178
|| |.||.: ..|
Human 1818 ED--------------------PPLDTD----------------------------------VLV 1828
Fly 2179 AGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEF 2243
.|...|.|..:.....:...|||.. ..|.|.| ..|::::
Human 1829 PGAPERHSPIQNLDPPLRPDSGSAP------PPAPRSF-------SGARIKV------------- 1867
Fly 2244 RIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQI 2308
.||...:|.|
Human 1868 ---------------------------PNYSPSRRPL---------------------------- 1877
Fly 2309 SAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSL-------GSG 2366
||: ||..:.|.|| |.|| |..
Human 1878 ----------------GGV-------SFGPLPSPGS---------------PSSLTHHIPTVGDP 1904
Fly 2367 FFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQ 2431
.| |.|..::. :|:..||..|
Human 1905 DF---PAPPRRSR-------------------------RPSPLAPRPP----------------- 1924
Fly 2432 IPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPI 2496
|...|..||||
Human 1925 -----------------------------PSRWASPPLKT------------------------- 1935
Fly 2497 QAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGD 2561
:||:.:| .|.::::.:|
Human 1936 --------------------------------------------SPQLRVP--PPTSVVTALT-- 1952
Fly 2562 GSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSG----- 2621
||:||..| |.|..:| ..|.:.|
Human 1953 ------------PTSGELAP-PGPAPSP-------------------------PPPEDLGPDFED 1979
Fly 2622 ---LQMLTAQSLQAQPQVIGTLIQP-QTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATTS 2682
:..|:|..|.....::|| :| |...:..||.|:..|. .|.||..|.:.||
Human 1980 MEVVSGLSAADLDFAASLLGT--EPFQEEIVAAGAMGSSHGG----------PGDSSEEESSPTS 2032
Fly 2683 PQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEPIVDLPAG 2747
..:.... ||:|:.....:|.|| |.:||.:
Human 2033 RYIHFPV-------------TVVSAPGLAPSATPG-----------------APRIEQL------ 2061
Fly 2748 YVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSMDYTSPVMVT 2812
|....||...|.:|.| |...|...| .|.:|.
Human 2062 --------DGVDDGTDSEAEAVQQ----------------------PRGQGTPPS----GPGVVR 2092
Fly 2813 AKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKA 2877
|.: .|.:|....||:. ||:.|| ...:|...
Human 2093 AGV---------------LGAAGDRARPPED------LPSEIV--------------DFVLKNLG 2122
Fly 2878 ASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQ 2942
..|.| ||.|...|.| |.|.:.|.: || .|
Human 2123 GPGDG---GAGPREESLP----------------------PAPPLANGS----------QP--SQ 2150
Fly 2943 QIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPV 3007
.:.|...: |.:| ...:|. .|.:.:::|..||
Human 2151 GLTASPAD------------PTRT---------FAWLPG------------APGVRVLSLGPAP- 2181
Fly 3008 VQSQFVMEP--QALEQQELANRV-QHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTN 3069
|| .|..:..|.|:: |.|...:..... |.|..:|.|...:.|.|.||:
Human 2182 -------EPPKPATSKIILVNKLGQVFVKMAGEGEP--------VPPPVKQPPLPPTISPTAPTS 2231
Fly 3070 RVLPMQQRQEPAPLSNECPVVS--SPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELK 3132
..|| |.||....|||. .|.||.| |.|
Human 2232 WTLP------PGPLLGVLPVVGVVRPAPPPP------------------------PPP------- 2259
Fly 3133 VSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGY 3197
:..:|...|. || .|:.:..:.|:
Human 2260 -------------LTLVLSSGPA-------------SP-------------PRQAIRVKRVS--- 2282
Fly 3198 LLDKHTFQ-VEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDN 3261
||. ..|.....|:...|:|:.:..:| ..:.|.:
Human 2283 -----TFSGRSPPAPPPYKAPRLDEDGEASED----------------TPQVPGL---------- 2316
Fly 3262 LTNDDCADSIATATTMEVDASAGYQQM------VEDVLATTAAQSAPTEEFEGALETAAVEAAAT 3320
.|.|:.:: |..||..........||..|.|:..
Human 2317 -------------------GSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQER------- 2355
Fly 3321 YINEMADAHVLDL-----KQLQNG-VELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQP-- 3377
:.:|.| .|:.:| .:|.|. ||....|..| :::..|||.|
Human 2356 -------SPLLPLPEDGPPQVPDGPPDLLLE---------SQWHHYSGEA---SSSEEEPPSPDD 2401
Fly 3378 --IQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGI 3440
.|.||: |||||.:||.|||||:.::.|:...|..:.|.||.|| |...|.....:.|.|.
Human 2402 KENQAPKR-TGPHLRFEISSEDGFSVEAESLEGAWRTLIEKVQEAR---GHARLRHLSFSGMSGA 2462
Fly 3441 QMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDS 3505
:::|:..:|:.:|.|||||.::|..|..:||::
Human 2463 RLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQ-------------------------------- 2495
Fly 3506 HGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNEL---VPRR 3567
|..|:|...|.:..||.|.|..:..:|||::|||:||..|........::|: ..||
Human 2496 ------GEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRR 2554
Fly 3568 GTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRER 3632
.|...|||||::|.||:|.|:.|||:||.||||||:|.::|:||||||||:|.:|||.||||||:
Human 2555 ATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREK 2619
Fly 3633 YYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGE 3697
:||.:|||||||::||..||||||.|||||||||.|||||:|:|:.:.|.|||:|||||||::||
Human 2620 FYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGE 2684
Fly 3698 ELTYDYKFPFED--EKIPCSCGSKRCRKYLN 3726
|||||||||.|| .|:||:||:||||::||
Human 2685 ELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2715
|