DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and SETD1A

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_055527.1 Gene:SETD1A / 9739 HGNCID:29010 Length:1707 Species:Homo sapiens


Alignment Length:2105 Identity:415/2105 - (19%)
Similarity:688/2105 - (32%) Gaps:653/2105 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1847 ALKANGSPSVTYES-NFEVSRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRF--SDSY 1908
            ||:........|:. :|.|:...|:.::    .|.:|   :.|:.| :.|.....||:|  .:.|
Human    31 ALRRPSQKVYRYDGVHFSVNDSKYIPVE----DLQDP---RCHVRS-KNRDFSLPVPKFKLDEFY 87

  Fly  1909 EAVVPINFLCSRLYWSSKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMA 1973
            ...:|:.                 |.|......|...|... |:.|.|      ...:||::.:.
Human    88 IGQIPLK-----------------EVTFARLNDNVRETFLK-DMCRKY------GEVEEVEILLH 128

  Fly  1974 QIARWHTSLARSEFLENGGTDWSGEFPNPNSCVPPDENTEEEPQQQADLLPPELKDAIFEDLPHE 2038
            ...|.|..|||..|....|.                    :|..:...|      .::..::.|.
Human   129 PRTRKHLGLARVLFTSTRGA--------------------KETVKNLHL------TSVMGNIIHA 167

  Fly  2039 LLDGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSL 2103
            .||......:..|:      .|...|.......|..:|.::..|..||.:.:.......:|:|:.
Human   168 QLDIKGQQRMKYYE------LIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRRRSSSDTAA 226

  Fly  2104 -----------GNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRR---KLS 2154
                       |||.|.|   :|...|::|..:      ..::.:....|:..|....|   ..|
Human   227 YPAGTTAVGTPGNGTPCS---QDTSFSSSRQDT------PSSFGQFTPQSSQGTPYTSRGSTPYS 282

  Fly  2155 KNLAEGVFLTLSSQQRNKKEMATVAGVSRR----QSISETSVEGVATTSGSVRSKSFTWSAAKRY 2215
            ::.|.....|.:|.:..:.|.:.....|||    .|.|.|:...:|.|:.:..|.|.:.|:....
Human   283 QDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSS 347

  Fly  2216 FEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHL 2280
            ...|.                ..|.::||  |.|.|.              ...|.:::.:||| 
Human   348 SSSSS----------------SSSSSQFR--SSDANY--------------PAYYESWNRYQRH- 379

  Fly  2281 PSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSL 2345
            .|..|..::.|   :..|.....|..:                    .:..|.||:         
Human   380 TSYPPRRATRE---EPPGAPFAENTAE--------------------RFPPSYTSY--------- 412

  Fly  2346 GQFGLQGLQQLQLQPQSLGSGFFLSQPN------PATQANTDDLQIYANSLQSLAANLGGGFTLA 2404
                        |.|:.       |:|.      ||::|...:      ..:......|||.:..
Human   413 ------------LPPEP-------SRPTDQDYRPPASEAPPPE------PPEPGGGGGGGGPSPE 452

  Fly  2405 QPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPL 2469
            :..|....:|...|.|.:|        .|:|.. .:.|.|.:.:|     |.:|.:.|.......
Human   453 REEVRTSPRPASPARSGSP--------APETTN-ESVPFAQHSSL-----DSRIEMLLKEQRSKF 503

  Fly  2470 KTVATKAAQQ---------AAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQN 2525
            ..:|:...::         |.....::.||....|...  .|.|...:....|...:|       
Human   504 SFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGPCTP--PPAPANFEDVAPTGSGEP------- 559

  Fly  2526 LLQPQLLFQSSTQTQAPQIILPQAQPQNIIS--------FVTGDGSQGQPLQYISIPTAGEY--K 2580
                     .:|:..      |:|..||..|        .::.|...|.|   ...||..:.  .
Human   560 ---------GATRES------PKANGQNQASPCSSGDDMEISDDDRGGSP---PPAPTPPQQPPP 606

  Fly  2581 PQPQPTATPTFLTTAPGAG-----ATYLQT----------------------DASGNLVLTTTPS 2618
            |.|.|...|.:|.:.| .|     ..||..                      |...:|.|     
Human   607 PPPPPPPPPPYLASLP-LGYPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLEL----- 665

  Fly  2619 NSGLQMLTAQ------SLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTG--GGSSG 2675
               :..|.||      |.|.|.|::..|.|   ::.|.|            ||....|  ||:.|
Human   666 ---MDRLGAQWGGMPMSFQMQTQMLTRLHQ---LRQGKG------------LIAASAGPPGGAFG 712

  Fly  2676 LEFATTSPQVILATQPMYYGLETIV-----QNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQA 2735
            ..|....|     .|...|||...:     :.....|::.....|| |.::....|:.:.   :.
Human   713 EAFLPFPP-----PQEAAYGLPYALYAQGQEGRGAYSREAYHLPMP-MAAEPLPSSSVSG---EE 768

  Fly  2736 SKIEP--IVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQ----TQDDTTTQILQNANF------ 2788
            :::.|  ..:|..|..:       .:|||.....::|.|:    .|.|...::::|..|      
Human   769 ARLPPREEAELAEGKTL-------PTAGTVGRVLAMLVQEMKSIMQRDLNRKMVENVAFGAFDQW 826

  Fly  2789 ---------QFQSVPTSSGASTSMDYT---SPVMVT----AKIPPVTQIKRTNAQAKAAGISGVG 2837
                     .||:...........:.|   .|.:::    ||....|.|:   |.|..:|:.|..
Human   827 WESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKSGGTTGIE---AFAFGSGLRGAL 888

  Fly  2838 KVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNM 2902
            ::|                             ..:||.|          .|..|:....:|:...
Human   889 RLP-----------------------------SFKVKRK----------EPSEISEASEEKRPRP 914

  Fly  2903 IRPIHKLEVKPKVMKPT---------PKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTIS 2958
            ..|..:.|..|:..|..         |..:::.....|.:.::...|..:               
Human   915 STPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSE--------------- 964

  Fly  2959 QQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQE 3023
                 .:...|:....:.....::.:..:.::..|..:.....:::....:|....:.......:
Human   965 -----GEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSD 1024

  Fly  3024 LANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECP 3088
            ..|.....|.|||||||:.|          ..:.|::|||::...:.....::.:.||.|.:..|
Human  1025 GENDSTSDSESSSSSSSSSS----------SSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP 1079

  Fly  3089 ---VVSSPTPPKPVEQPIIHQMTSASVSKCYAQKST-------------------------LPSP 3125
               .|..|| |.|||.|:..::..:.|:....|:::                         .|:|
Human  1080 PPREVPVPT-PAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAP 1143

  Fly  3126 VYEAELKVSSVLESIVP------DVTMDAI-----LEEQPVTESIYTEGLYEKNSPGESKTEQLL 3179
            ....:.:.||.:..:.|      .|:..||     .|..|.|..       :...||.:      
Human  1144 APRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPP-------QAKFPGPA------ 1195

  Fly  3180 LQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYR--------EEDLEEEEDEDDDFSLKMATS 3236
              .::..:..::.:.| ..|| |...|:....:|.|        ...|.|||:.:....:.:|..
Human  1196 --SRKAPRGVERTIRN-LPLD-HASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVL 1256

  Fly  3237 ACNDHEMSDSEE-----PAVKDKISKILDNLTNDDCADSIATATTMEVD----------ASAGYQ 3286
            |  |..::.:..     |||:                ||.||.|:.|.:          ....|.
Human  1257 A--DLALTPARRGLPALPAVE----------------DSEATETSDEAERPRPLLSHILLEHNYA 1303

  Fly  3287 QMV------------EDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNG 3339
            ..|            |.|.|..|..|:|.:|        .:||....:.|..:.....|:|.:..
Human  1304 LAVKPTPPAPALRPPEPVPAPAALFSSPADE--------VLEAPEVVVAEAEEPKPQQLQQQREE 1360

  Fly  3340 VELELRRRKEEQRTVSQEQEQS--------KAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSE 3396
            .|.|.....||:...|.:...|        :.::...|....||.|...|     |...||.:||
Human  1361 GEEEGEEEGEEEEEESSDSSSSSDGEGALRRRSLRSHARRRRPPPPPPPP-----PPRAYEPRSE 1420

  Fly  3397 DGFTYKSSSIT-EIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGV 3460
                ::..:|. :||....::                  .||..:::      ..:.|::|..|.
Human  1421 ----FEQMTILYDIWNSGLDS------------------EDMSYLRL------TYERLLQQTSGA 1457

  Fly  3461 EKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDC 3525
            :..:. |...|....|::|......                            .||...|:....
Human  1458 DWLND-THWVHHTITNLTTPKRKRR----------------------------PQDGPREHQTGS 1493

  Fly  3526 ARCEPY--SNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPMA------------ 3576
            ||.|.|  .::.|.|.:..:.....:|...|..|.::..|..||.....|..|            
Human  1494 ARSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAIMDSDLL 1558

  Fly  3577 ----MKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSR 3637
                :|:|..|..:.      ||.||..||:..:.|.|.||||||.|:.||..:.|.||:.|...
Human  1559 KLNQLKFRKKKLRFG------RSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMREKRYVQE 1617

  Fly  3638 GIG-CYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTY 3701
            ||| .|:|::|.:.::|||..||.||||||||.||||:||:.|...|.|:|::.:.|...||:||
Human  1618 GIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVIYSKQPIGVDEEITY 1682

  Fly  3702 DYKFPFEDEKIPCSCGSKRCRKYLN 3726
            |||||.||.||||.||::.||..||
Human  1683 DYKFPLEDNKIPCLCGTESCRGSLN 1707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390
PRK13914 <1006..>1224 CDD:237555
PHD1_KMT2A_like 1268..1344 CDD:276981
PHD 1346..1390 CDD:214584
PHD3_KMT2A_like 1423..1479 CDD:276983
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1890..1937 CDD:461787 9/48 (19%)
FYRC 3388..3476 CDD:197781 14/88 (16%)
SET_KMT2A_2B 3575..3726 CDD:380947 74/167 (44%)
SETD1ANP_055527.1 Interaction with WDR82. /evidence=ECO:0000269|PubMed:37030068 60..89 9/32 (28%)
RRM_Set1A 92..186 CDD:409964 24/149 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..308 23/122 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 331..363 8/49 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..486 27/170 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..655 29/176 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..854 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 891..1251 69/446 (15%)
PRK12323 <1070..>1130 CDD:481241 14/60 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1264..1293 9/44 (20%)
HCFC1-binding motif (HBM) 1299..1303 0/3 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1307..1417 25/122 (20%)
Interaction with CFP1 1415..1450 9/62 (15%)
N-SET 1425..1562 CDD:463344 29/189 (15%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000269|PubMed:17998332 1450..1537 20/115 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1472..1499 8/54 (15%)
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1492..1497 2/4 (50%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1537..1542 1/4 (25%)
SET_SETD1 1556..1703 CDD:380946 71/152 (47%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.