Protein Alignment trx and SET1

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_011987.1
• Gene: SET1 / 856519
• SGDID: S000001161
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 1188
• Identity: 244/1188 - (20%)
• Similarity: 411/1188 - (34%)
• Gaps: 379/1188 - (31%)

  Fly  2700 VQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEPIVDLPAGYVVLNNTGDASS----- 2759
            |.||:.||...:.|....:|.|..                     |:  |:..||.:..|
Yeast   111 VHNTLASSSGSLPTESALLLQQRP---------------------PS--VLRYNTDNLKSKFHYF 152

  Fly  2760 ---AGTFLNAASVLQQQTQDDTTTQI-------LQNANFQFQSVPTSSGASTSMDYTSPVMVTAK 2814
               .|.|.|...:|..:..|...::.       ||:..|:|
Yeast   153 DPIKGEFFNKDKMLSWKATDKEFSETGYYVVKELQDGQFKF------------------------ 193

  Fly  2815 IPPVTQIKRTNAQAKAA------GISGVGKV-------------------------PPQPQVVNK 2848
                 :||..:.:.||:      ||...|||                         ||..::|..
Yeast   194 -----KIKHRHPEIKASDPRNENGIMTSGKVATHRKCRNSLILLPRISYDRYSLGPPPSCEIVVY 253

  Fly  2849 VLPTSIVTQQSQVQVKNSNLKQSQVKG------------------KAASGTGTTCGAPPSIASKP 2895
            ....|..|....:.:||...|..::..                  |.||..|....|..:..|..
Yeast   254 PAQDSTTTNIQDISIKNYFKKYGEISHFEAFNDPNSALPLHVYLIKYASSDGKINDAAKAAFSAV 318

  Fly  2896 ------------------LQKKTNMIRPIHK-LEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQ 2941
                              |.|.:.:...|.| :|:..|.::   |:|.......:::.:.:...:
Yeast   319 RKHESSGCFIMGFKFEVILNKHSILNNIISKFVEINVKKLQ---KLQENLKKAKEKEAENEKAKE 380

  Fly  2942 QQIPAVVVNQVPKV-TISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEA 3005
            .|...:.:.:.||| |:|                   |....::.:....:.|..:.|::.:::.
Yeast   381 LQGKDITLPKEPKVDTLS-------------------HSSGSEKRIPYDLLGVVNNRPVLHVSKI 426

  Fly  3006 PVVQSQFVME-----------------PQALEQQELANRVQHFSTSSSSSSSNCSLPTN------ 3047
            .|.:.:|.:|                 |..:  ..:.|.:.|..|.|::.|.|.::.:.
Yeast   427 FVAKHRFCVEDFKYKLRGYRCAKFIDHPTGI--YIIFNDIAHAQTCSNAESGNLTIMSRSRRIPI 489

  Fly  3048 ------VVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVVSSPTP------PKPVE 3100
                  ::...|.:.....|||::..||..:..:.::|         .:.:...      .|.:.
Yeast   490 LIKFHLILPRFQNRTRFNKSSSSSNSTNVPIKYESKEE---------FIEATAKQILKDLEKTLH 545

  Fly  3101 QPIIHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLY 3165
            ..|..::...:|... ...:..|..:.:.|||.....:.|...:..|.:..::.........|||
Yeast   546 VDIKKRLIGPTVFDA-LDHANFPELLAKRELKEKEKRQQIASKIAEDELKRKEEAKRDFDLFGLY 609

  Fly  3166 ----EKNSPGESKTEQLLLQQQ--QREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDL---EE 3221
                :.|.....:...|.|...  :|::|:..:....:||::.|   :..:|....:|.:   .:
Yeast   610 GGYAKSNKRNLKRHNSLALDHTSLKRKKLSNGIKPMAHLLNEET---DSKETTPLNDEGITRVSK 671

  Fly  3222 EEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQ 3286
            |.||:|:   .|.:|:      |:.||....||..|            |.:..||.|.|...|.:
Yeast   672 EHDEEDE---NMTSSS------SEEEEEEAPDKKFK------------SESEPTTPESDHLHGIK 715

  Fly  3287 QMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINE-MADAHVLDLKQLQNGVELELR---RR 3347
            .:|.|       |:..::..:.   ::..:..||.|.| :......|||..|....::|:   :.
Yeast   716 PLVPD-------QNGSSDVLDA---SSMYKPTATEIPEPVYPPEEYDLKYSQTLSSMDLQNAIKD 770

  Fly  3348 KEEQRTVSQEQEQSKAAIVP-TAAAPE-----PPQPIQEPKKMTGPHL-----LYEIQSEDGFTY 3401
            :|:...:.|........:.| |:||.|     ..:.:.|.:|.:...:     |::.:.:.|.::
Yeast   771 EEDMLILKQLLSTYTPTVTPETSAALEYKIWQSRRKVLEEEKASDWQIELNGTLFDSELQPGSSF 835

  Fly  3402 KSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKY 3466
            |:....:|.:|                                ||.|                 |
Yeast   836 KAEGFRKIADK--------------------------------LKIN-----------------Y 851

  Fly  3467 TPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARC--E 3529
            .|  |:|..:........|.                                |.|.|....|  |
Yeast   852 LP--HRRRVHQPLNTVNIHN--------------------------------ERNEYTPELCQRE 882

  Fly  3530 PYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRR------------GTGSNLPMAMKYRTL 3582
            ..||:...|......|..|           ||....||            ||.|.|   :....|
Yeast   883 ESSNKEPSDSVPQEVSSSR-----------DNRASNRRFQQDIEAQKAAIGTESEL---LSLNQL 933

  Fly  3583 KETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIG-CYMFKI 3646
            .:..|. |...||.||..|||....|.|.||:|||.||.||..:.:.||:.|...||| .|:|::
Yeast   934 NKRKKP-VMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRV 997

  Fly  3647 DDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFE--- 3708
            |:|.|:|||.:|..||||||||:|||.:|::.:.|.:.|:|:|||.|...|||||||||..|
Yeast   998 DENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDD 1062

  Fly  3709 DEKIPCSCGSKRCRKYLN 3726
            :|::||.||:..|:.:||
Yeast  1063 EERLPCLCGAPNCKGFLN 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	12/92 (13%)
		SET_KMT2A_2B	3575..3726	CDD:380947	71/154 (46%)
SET1	NP_011987.1	AF-4	<11..>136	CDD:461550	8/45 (18%)
		RRM_scSet1p_like	246..360	CDD:409743	19/116 (16%)
		SET_assoc	422..486	CDD:432058	10/65 (15%)
		N-SET	763..932	CDD:463344	41/265 (15%)
		SET_SET1	926..1076	CDD:380998	71/153 (46%)