DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and ATX2

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001077464.4	Gene:	ATX2 / 837093	AraportID:	AT1G05830	Length:	1083	Species:	Arabidopsis thaliana

Alignment Length:	836	Identity:	191/836 - (22%)
Similarity:	290/836 - (34%)	Gaps:	298/836 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  3109 SASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIYT--EGLYEKNSPG 3171
            :||..:|   :...|..:..|:|...::..:|:.|             ||:..  :||..|.|.|
plant   304 AASFEEC---QDFEPRDIIWAKLTGHAMWPAIIVD-------------ESVIVKRKGLNNKISGG 352

  Fly  3172 ESKTEQLL-LQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMAT 3235
            .|...|.. .....|.|:.|.:.....||.:     .|:.....|.|:..||        .||
plant   353 RSVLVQFFGTHDFARIQVKQAVSFLKGLLSR-----SPLKCKQPRFEEAMEE--------AKM-- 402

  Fly  3236 SACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQS 3300
                  .:.:.:.|...|::.|:.|.    ||::.|.:.   |.|:|.......:|    .....
plant   403 ------YLKEYKLPGRMDQLQKVADT----DCSERINSG---EEDSSNSGDDYTKD----GEVWL 450

  Fly  3301 APTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAI 3365
            .|||             ....::.:.|..:::|.::....|.    .|:.:.|..:....::..|
plant   451 RPTE-------------LGDCLHRIGDLQIINLGRIVTDSEF----FKDSKHTWPEGYTATRKFI 498

  Fly  3366 V---PTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVF---EAVQVARRAH 3424
            .   |.|:|....:.:::.:..|.|  ::.:.:..|..:|..:.:..|.|::   :.:|:|  :.
plant   499 SLKDPNASAMYKMEVLRDAESKTRP--VFRVTTNSGEQFKGDTPSACWNKIYNRIKKIQIA--SD 559

  Fly  3425 GLTPLPEGPLADMGGIQMIGLKTNALKYLIEQL-----PG-----------------------VE 3461
            ....|.||  ....|..|.|.....:..||:.|     |.                       ||
plant   560 NPDVLGEG--LHESGTDMFGFSNPEVDKLIQGLLQSRPPSKVSQRKYSSGKYQDHPTGYRPVRVE 622

  Fly  3462 ----------------------KCSKYTPKYHKR--------NG--------------------- 3475
                                  :|.|.....|.|        ||
plant   623 WKDLDKCNVCHMDEEYENNLFLQCDKCRMMVHTRCYGQLEPHNGILWLCNLCRPVALDIPPRCCL 687

  Fly  3476 --------NVSTAANGAH---------------------------------------GGNLGG-- 3491
                    ..:|....||                                       |.:.|.
plant   688 CPVVGGAMKPTTDGRWAHLACAIWIPETCLLDVKKMEPIDGVKKVSKDRWKLLCSICGVSYGACI 752

  Fly  3492 --------------SSASAALSVSGGDSHGLLDYGSDQDELEE---------------------- 3520
                          .:.:|.|.|...|...|.....|.||.::
plant   753 QCSNNTCRVAYHPLCARAAGLCVELADEDRLFLLSMDDDEADQCIRLLSFCKRHRQTSNYHLETE 817

  Fly  3521 ----------------NAYDCARCEPYSNRSEYDMFSWLASRHRKQP--------IQVFV--QP- 3558
                            |...|||.|||         ::|..|.||:|        .::||  ||
plant   818 YMIKPAHNIAEYLPPPNPSGCARTEPY---------NYLGRRGRKEPEALAGASSKRLFVENQPY 873

  Fly  3559 -----SDNEL----------VPRRGTGSN-LPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKD 3607
                 |.:|.          :.:..|.|| |.||.||..:||||:..:...:|.|||.|::....
plant   874 IVGGYSRHEFSTYERIYGSKMSQITTPSNILSMAEKYTFMKETYRKRLAFGKSGIHGFGIFAKLP 938

  Fly  3608 IEAGEMVIEYAGELIRSTLTDKRER--YYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEP 3670
            ..||:|||||.|||:|..:.||||.  |....|.|.|||:||:..|:|||..|:.|..|||.|||
plant   939 HRAGDMVIEYTGELVRPPIADKREHLIYNSMVGAGTYMFRIDNERVIDATRTGSIAHLINHSCEP 1003

  Fly  3671 NCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3726
            ||||:|:.:.|.:||||||.|.:.:.|||||||:|...||::.|.||..|||..:|
plant  1004 NCYSRVISVNGDEHIIIFAKRDVAKWEELTYDYRFFSIDERLACYCGFPRCRGVVN 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781	24/177 (14%)
		SET	3590..3710	CDD:214614	61/121 (50%)
ATX2	NP_001077464.4	PWWP	313..403	CDD:279227	26/123 (21%)
		FYRN	464..513	CDD:283589	9/52 (17%)
		FYRC	524..610	CDD:197781	16/89 (18%)
		PHD_ATX1_2_like	628..674	CDD:276969	6/45 (13%)
		ePHD_ATX1_2_like	685..806	CDD:277132	13/120 (11%)
		SET	<706..1056	CDD:225491	108/358 (30%)
		SET	919..1038	CDD:214614	60/118 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1076
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870