DRSC/TRiP Functional Genomics Resources

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Protein Alignment trx and ezh2

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001070747.1 Gene:ezh2 / 768133 ZFINID:ZDB-GENE-041111-259 Length:760 Species:Danio rerio


Alignment Length:868 Identity:154/868 - (17%)
Similarity:279/868 - (32%) Gaps:239/868 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  2899 KTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIP 2963
            |...|:|:|       :|.|...::......:.....:..  :|.||...:|.|..|.:.....|
Zfish    61 KLRRIQPVH-------IMTPVSSLRGTRECTVDSGFSEFS--RQVIPLKTLNAVASVPVMYSWSP 116

  Fly  2964 AQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITL-----------AEAPVVQSQ-FVMEP 3016
            .| |...::...::|    ..|....::..|....|..|           .|...:..: ||...
Zfish   117 LQ-QNFMVEDETVLH----NIPYMGDEILDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELV 176

  Fly  3017 QALEQ---------------------------QELANRVQHFSTSSSSSSSNCSLPTN-VVNPMQ 3053
            .||.|                           .:..:..:..|:.|.::..:...|:: :...:.
Zfish   177 NALNQYSDNEEDDEEDDHHDYKFEKMDLCDGKDDAEDHKEQLSSESHNNDGSKKFPSDKIFEAIS 241

  Fly  3054 QQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNEC-PVVSSPTPPKPVEQPIIHQMTSASVSKCYA 3117
            ...|.  ..||.....:...:.::|.|..|..|| |.:..|.......:..:|...:....:|:.
Zfish   242 SMFPD--KGSTEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFK 304

  Fly  3118 QKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIY------TEGLYEKNSPGESKTE 3176
                     |:..|.......:......|:.:::.:|.  .||      .:|:..:...|.....
Zfish   305 ---------YDCFLHPFQATPNTYKRKNMENLVDSKPC--GIYCYMYMVQDGMVREYPAGVVPER 358

  Fly  3177 QLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYRE--EDLEEEEDEDDDFSLKMATSACN 3239
            .....::...:...:|.|:.......|...|..|||..||  .|..:..|:|||           
Zfish   359 AKTPSKRSTGRRRGRLPNSNSRPSTPTVNSETKDTDSDREGGADGNDSNDKDDD----------- 412

  Fly  3240 DHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTE 3304
                         ||         .|:        ||...:|::..|..|:..|::...::....
Zfish   413 -------------DK---------KDE--------TTSSSEANSRCQTPVKLKLSSEPPENVDWS 447

  Fly  3305 EFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTA 3369
            ..|.:|....:  ...|.|..|.|.::..|..:...|..::                :::|:..|
Zfish   448 GAEASLFRVLI--GTYYDNFCAIARLIGTKTCRQVYEFRVK----------------ESSIIARA 494

  Fly  3370 AAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPL 3434
            .|.:...|.::.|:   .|.|:..........|..|...::                        
Zfish   495 PAVDENTPQRKKKR---KHRLWATHCRKIQLKKDGSSNHVY------------------------ 532

  Fly  3435 ADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVS-----TAANGAHGGNLGGSSA 3494
                                          .|.|..|.|....|     ||.|.........|..
Zfish   533 ------------------------------NYQPCDHPRQPCDSSCPCVTAQNFCEKFCQCSSEC 567

  Fly  3495 SAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPS 3559
                                     :|.:...||:...|.             ::.|..:.|:..
Zfish   568 -------------------------QNRFPGCRCKAQCNT-------------KQCPCYLAVREC 594

  Fly  3560 DNELVPRRGTGSNLP---MAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGEL 3621
            |.:|....|...:..   ::.|..:::...|.::.:..|.:.|.|::..:.::..|.:.||.||:
Zfish   595 DPDLCLTCGAAEHWDSKNVSCKNCSIQRGAKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEI 659

  Fly  3622 IRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHII 3686
            |.....|:|.:.|| :.:..::|.::::.|||||.:||..||.||...||||:||:.:.|...|.
Zfish   660 ISQDEADRRGKVYD-KYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIG 723

  Fly  3687 IFALRRIVQGEELTYDYKFPFED 3709
            |||.|.|..||||.:||::...|
Zfish   724 IFAKRAIQTGEELFFDYRYSQAD 746

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390
PRK13914 <1006..>1224 CDD:237555
PHD1_KMT2A_like 1268..1344 CDD:276981
PHD 1346..1390 CDD:214584
PHD3_KMT2A_like 1423..1479 CDD:276983
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1890..1937 CDD:461787
FYRC 3388..3476 CDD:197781 8/87 (9%)
SET_KMT2A_2B 3575..3726 CDD:380947 47/135 (35%)
ezh2NP_001070747.1 EZH2_WD-Binding 39..68 CDD:463308 2/6 (33%)
PRC2_HTH_1 159..262 CDD:436286 12/104 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..231 2/22 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..444 23/128 (18%)
preSET_CXC 573..604 CDD:408079 7/43 (16%)
SET_EZH2 623..742 CDD:380995 45/119 (38%)
Blue background indicates that the domain is not in the aligned region.

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