|
Fly 80 ASSSAGSGNSGNGSSSGSSTG-SGSSGSGSTNGGSVNGGTHHKSAANLDKEAVTKDQNGDGDKTR 143
|:::.|....|.||:.|...| ...||.|...||..||....:.|.. |
Mouse 2 AAAAGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVRVALR-----------------R 49
Fly 144 GNVSSAPSGK--------LSAAASGKALSKSSRTFSASTSVTSSGRSSGSSPDGNSGA-----SS 195
|..::.|.|. |......:.|.:..|.::.:......||..|.....|.|. ||
Mouse 50 GGGAAGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGARVQRGRGRGRGRGWGPNRGCMPEEESS 114
Fly 196 DGAS-----SGISCGKSTAKSTEASSGKLAKTTGAGTCSSAKSSKASSGTTSEATTSGLSGACLK 255
||.| .|....:..|.|:..|:.: ::..:|..|...:..|:.|. .
Mouse 115 DGESEEEEFQGFHSDEDVAPSSLRSALR------------SQRGRAPRGRGRKHKTTPLP----P 163
Fly 256 ALFVATPATSTGLACALVSPGGSSQGGTFPISAALLRARKNSNKKFKNLNLARGEVMLPSTSKLK 320
.|...|| |.| |...:| ||| ..|.::.
Mouse 164 RLADVTP----------VPP-------------------KAPTRK-------RGE---EGTERMV 189
Fly 321 Q-LNSPVVDNPSPSPPIASG-----STPSVEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDPSP 379
| |...:..:.:|.||.:.. |||....|...|....|........||.|....:.:...|
Mouse 190 QALTELLRRSQAPQPPRSRARAREPSTPRRSRGRPPGRPAGPCRKKQQAVVLAEAAVTIPKPEPP 254
Fly 380 SSCTAAANGAASGKGSASNGPPAMASSGDGSSPKSGADTGPSTSSTTAKQKKTVTFRNVLETSDD 444
.......|.|.|.|.....|| |.| :||.|...|........:
Mouse 255 PPVVPVKNKAGSWKCKEGPGP------GPG-TPKRGGQPGRGGRGGRGR---------------- 296
Fly 445 KSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSLKFRSA 509
.||| ..::.|.::|...: |:..|
Mouse 297 -------------------------------GRGG-----LPLMIKFVSKAKKV-KMGQL----- 319
Fly 510 GASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDSPE-------DQNNAEDDEMDDD 567
|...|||......|.|.. .||..:| .|.|| .:...|::|.:::
Mouse 320 -----SQELESGQGHGQRGESWQ-DAPQRKD---------GDEPERGSCRKKQEQKLEEEEEEEE 369
Fly 568 DDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADE----RDPDEKQL--------VMDSHFVLPK 620
.:.||.||.|:|||:|.: |:..|||::...:| ::.:|.:| |......||.
Mouse 370 KEGEEKEEKDDNEDNNKQ---EEEEETERAVAEEEAMLAKEKEEAKLPSPPLTPPVPSPPPPLPP 431
Fly 621 RSTR----SSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSASTNLKLG 681
.||. :|.:..| :|...|||
Mouse 432 PSTSPPPPASPLPPP---------VSPPPPLS--------------------------------- 454
Fly 682 KETFFNFGTLKPNSSAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGS 746
...:.||:....||..:| ||.|
Mouse 455 ----------------------------------PPPYPAPEKQEESPPLVP------ATCS--- 476
Fly 747 LASTNSSTVTPTPSACSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTAN--T 809
.......:||:..| .:|..::...|.: |.|.| |
Mouse 477 -RKRGRPPLTPSQRA---------EREAARSGPEGTL--------------------SPTPNPST 511
Fly 810 SSGSQQYLQCKGNEGSPCSIHSAKSQLKNFKKFYKDRCTA-----CWLKKCMISFQLPAAHRSRL 869
::||.. |.||..:..:.:.|||.::|.....:| ....:..:....|...:...
Mouse 512 TTGSPL-------EDSPTVVPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEA 569
Fly 870 SAILPPGMRGEAAAREEKSAELLSPTGSLRFTSTASSSSP------SVVASTSVKWKSSGDSTSA 928
|.:.||......|.:| ...:.||. |..:..|:..| |::...:.:| ||.
Mouse 570 SIVRPPVATSPPAPQE--PVPVSSPP---RVPTPPSTPVPLPEKRRSILREPTFRW------TSL 623
Fly 929 LTSIKP----NPLAENNVTFGSTPLLRPAILENPLF------LKI--SNAADQKLAAAEAISPSL 981
...:.| .|.|.:.....:||..||.:|..|.| ||| |......|.|.|...|.|
Mouse 624 TRELPPPPPAPPPAPSPPPAPATPSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGALETPEPEL 688
Fly 982 TKKNSKQEKEKVKESEQSEKL---------LSPTQAGTKKSGA---AEAQVEEVQ---------- 1024
...:....:.:.:...::..| .||.:......|| :|.|..::|
Mouse 689 PPADDSPAEPEPRAVGRTNHLSLPRFVPVVTSPVKVEVPPHGAPALSEGQQLQLQQPPQALQTQL 753
Fly 1025 ------PQKEEA--PQTSTTTQP------------------------------------------ 1039
||:.:| |.:...|.|
Mouse 754 LPQALPPQQPQAQPPPSPQHTPPLEKARVASLGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQK 818
Fly 1040 -SASNGASHGVPQAELAGETNATGD-----------TLKRQRID-----LKGPRVKHVCRSASIV 1087
:||...|..|...|..|....|.| ..||.|.. |:|||:|||||.|::.
Mouse 819 VAASMPLSPAVQTEEAVGTVKQTPDRGCVRSEDESMEAKRDRASGPESPLQGPRIKHVCRHAAVA 883
Fly 1088 LGQPLATFGED---------QQPEDAA----------------DMQQEIAAPVPSAIMEP----- 1122
|||..|...|| :..:|.| ..::::.:..|....||
Mouse 884 LGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAGPGGDSEPTGSTG 948
Fly 1123 ----SPEK--PTH----------------IVTDENDNCASCKTSPV--GDESKPS-----KSSGS 1158
:|.: |:| :...:..:|.:|...|. |..:|.. |..
Mouse 949 ALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCD-- 1011
Fly 1159 AQAEVKKATALGKEG--------------------------TASAAGGSSAKV-TTRNAAVASNL 1196
:.|.:|...|.|:| ..:.||||..:| .|.......:|
Mouse 1012 -KIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGSREEVGATPGPEEQDSL 1075
Fly 1197 IVAASKKQRNGDIATSSSVTQSSNQTQ--------GRKTKEH----------------------- 1230
::.....:|......|..|.:.|:.:: .|..:||
Mouse 1076 LLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQSRPRKPTLQPVLQ 1140
Fly 1231 -RQQRTL-----------------------------ISIDFWENYDPAEVCQTGFGLIVTETV-- 1263
:.:|.| :.:||.|:.|...|...| ||.|..:|
Mouse 1141 LKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMG-GLSVLTSVPG 1204
Fly 1264 AQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSS 1328
....:|.||.|.||..|:||..||:|:|.:|::: :..||.
Mouse 1205 GPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEE-------------------------AERPSP 1244
Fly 1329 SLNQLTQRLNWLCPRCTVCYTCNMSS-GSK--VKCQKCQKNYHSTCLGTS--KRLLGADRPLICV 1388
. .|..|.|.||..|:.|.... ||| ::|::|:..||..|||.| .|.....|..||.
Mouse 1245 Q-----HRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICS 1304
Fly 1389 NCLKCKSCSTTKVS----KFVGNLPMCTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQW 1449
.|::||||..|... ::.|:..:|..|.:|.:|||:||||.|||:|||::.|||:|..|..|
Mouse 1305 ACVRCKSCGATPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHW 1369
Fly 1450 VHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWRQAVMEEFKASLYSVLKLLSK 1514
||:||||||||.|.:||.||:|:.:.|..||...: ..||:|:....:..|..||:.|..
Mouse 1370 VHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQ------PRWREALSGALQGGLRQVLQGLLS 1428
Fly 1515 SRQACALLKLSPRKKLRCT-CGASSNQ-----GKLQPKALQFSSGSDNGLGSDGESQNSDDVYEF 1573
|:.|..| |.|| ||....| ..||....:|..|....:.|..|...:..:...
Mouse 1429 SKVAGPL--------LLCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFMEDVVAILMRHS 1485
Fly 1574 KDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSF--SLVDIKQKIAGNSYVSLAEFNYDMSQV 1636
::.:..:::..:.|....:|.|..:.....:|...: ....:...:..|: |
Mouse 1486 EEGETPERRAGSQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNA-------------V 1537
Fly 1637 IQQSNCDELDIAYKELLSEQFPWFQNETKACTDALEEDMFESCSGGNYEDLQDTGGVSASVYNEH 1701
:..| ||..|.: |.|.|: |:...| |..|..||:..::.
Mouse 1538 LPPS----LDHVYAQ-------WRQQES------------ETPESG-----QPPGDPSAAFQSKD 1574
Fly 1702 STSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTN 1766
..:.:. || |.|.|..|.|.|:..|.|..||||.|.:.|.|.|
Mouse 1575 PAAFSH-----LD------------------DPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVN 1616
Fly 1767 CAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFL 1831
||:||||||||.||||:|||:||||||.::|.:|...||||||.:.||..::|:.|||:..|.|.
Mouse 1617 CAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQ 1681
Fly 1832 TDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVE---LDRKRKKL--IEPARVQFHIGS 1891
.||.::|..|.. ..:|...|| ...|:|.|.|||: ::.|||.| :||..:...|||
Mouse 1682 DDKKVFCQKHTD-----LLDGKEIVT-PDGFDVLRRVYVDFEGINFKRKFLTGLEPDVINVLIGS 1740
Fly 1892 LEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSS----KEPW---KIVEYTVRTTIQNSSSTLTA 1949
:.:..||.: ...||....:.||.:.|||||||: :..| :|:||
Mouse 1741 IRINSLGTL-SDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEY--------------- 1789
Fly 1950 LDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDWSGEFPNPNSCVPPDENTEE 2014
|.: .|..:.|.| :.|..:.::..| |.|:|
Mouse 1790 ----RPW-----GPREEPVHL---EAAEENQTIVHS--------------PTPSS---------- 1818
Fly 2015 EPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQ 2079
||....|| |:....|..|..|. ..|..||..|..|.::....:.:|..|.:....|.:.::
Mouse 1819 EPPNHDDL--PDTDSLIPGDPVHH--SPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSR 1879
Fly 2080 NQQAGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAM 2144
....| .|.| |..:| ...||....:.|: |:|..
Mouse 1880 RPLGG----------------VSFG---PLPSP--------GSPSSLTHHIPTV------GDSDF 1911
Fly 2145 ATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSKSFTW 2209
....:| .|....:||....||| ||..:|:
Mouse 1912 PAPPRR------------------SRRPSPLATRPPPSRR-------------TSSPLRT----- 1940
Fly 2210 SAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYD 2274
:.::|: .|||:
Mouse 1941 ---------------SPQLRV--------------------PLSTS------------------- 1951
Fly 2275 AFQRHLPSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQV 2339
:.:.:||.
Mouse 1952 -----VTALTPTS---------------------------------------------------- 1959
Fly 2340 QSLGSLGQFGLQGLQQLQLQP-QSLGSGFFLSQPNPATQANTDDLQIY----ANSLQSLAANLGG 2399
|:.....|....|.| :.||..| :|:::. |..|...|:.||
Mouse 1960 ------GELAPPDLAPSPLPPSEDLGPDF-------------EDMEVVSGLSAADLDFAASLLG- 2004
Fly 2400 GFTLAQPTVTAPAQPQLI---AVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLP 2461
|.|.|.::: ||.::..|. ..:.:...:||..|
Mouse 2005 ---------TEPFQEEIVAAGAVGSSQGGP------GDSSEEEASPTTHY--------------- 2039
Fly 2462 LTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNL 2526
|..|:||:....
Mouse 2040 -----------------------------------------------------VHFPVTVVSGPA 2051
Fly 2527 LQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTF 2591
|.| |:...||:| :.:.....|..|:.:.:| ||:...||
Mouse 2052 LAP------SSLAGAPRI-------EQLDGVDDGTDSEAEAVQ------------QPRGQGTP-- 2089
Fly 2592 LTTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQ 2656
.:.||.|. ||
Mouse 2090 -PSGPGVGR-------------------------------------------------GG----- 2099
Fly 2657 PGSNQQPLILGGTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQ 2721
:||..|
Mouse 2100 --------VLGAAG--------------------------------------------------- 2105
Fly 2722 NASFSATTTQVFQASKIEPIVDLPAGYV--VLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQ 2784
.:.:|..|||:..| ||.|.|......
Mouse 2106 --------------DRAQPPEDLPSEIVDFVLKNLGGPGEGA----------------------- 2133
Fly 2785 NANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKV 2849
|..:..|:|:: ||:.. |..|||.
Mouse 2134 -AGPREDSLPSA-------------------PPLAN----------------GSQPPQS------ 2156
Fly 2850 LPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTC---GAPPSIASKPLQKKTNMIRPIHKLEV 2911
|.|| .|..|.|.. ||| .:..|.:
Mouse 2157 LSTS-----------------------PADPTRTFAWLPGAP----------------GVRVLSL 2182
Fly 2912 KPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQM 2976
.|....|.|.... .::||::.:|.: :...:.:.
Mouse 2183 GPAPEPPKPATSK---------------------IILVNKLGQVFV-----------KMAGEGEP 2215
Fly 2977 IHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSN 3041
:..|.:|.||. |||
Mouse 2216 VAPPVKQPPLP----------PII----------------------------------------- 2229
Fly 3042 CSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVVS------SPTPPKPVE 3100
..|.||:..|| |.||.:..|||. :|.||.|
Mouse 2230 ---------------------PPTAPTSWTLP------PGPLLSVLPVVGVGVVRPAPPPPPP-- 2265
Fly 3101 QPIIHQMTSASVSKCYAQKSTLPSPVYEA-ELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGL 3164
|:....:|.. |||..:| .:|..|......|.|
Mouse 2266 -PLTLVFSSGP-----------PSPPRQAIRVKRVSTFSGRSPPV-------------------- 2298
Fly 3165 YEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDF 3229
|..:||.:| :||.|..||.
Mouse 2299 -----PPPNKTPRL-------------------------------------DEDGESLEDA---- 2317
Fly 3230 SLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLA 3294
|.: |.: :.:|:.::
Mouse 2318 -----------HHV-----PGI-----------------------------SGSGFSRV------ 2331
Fly 3295 TTAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQE 3359
.::|..| .|| |:|....|:....|..:.
Mouse 2332 --------------RMKTPTV----------------------RGV-LDLNNPGEQPEEESPGRP 2359
Fly 3360 QSKAAIVPTAAAP-----------------------------EPPQP----IQEPKKMTGPHLLY 3391
|.:..::|.|.|| |||.| .|.||:: ||||.:
Mouse 2360 QDRCPLLPLAEAPSQALDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRV-GPHLRF 2423
Fly 3392 EIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQ 3456
||.|:|||:.::.|:...|..:.|.||.|| |...|.....:.|.|.:::|:..:|:.:|.||
Mouse 2424 EISSDDGFSVEAESLEVAWRTLIEKVQEAR---GHARLRHLSFSGMSGARLLGIHHDAVIFLAEQ 2485
Fly 3457 LPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEEN 3521
|||.::|..|..:||:: |..|:|...|
Mouse 2486 LPGAQRCQHYKFRYHQQ--------------------------------------GEGQEEPPLN 2512
Fly 3522 AYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNEL---VPRRGTGSNLPMAMKYRTLK 3583
.:..||.|.|..:..:|||::|||:||..|........::|: ..||.|...|||||::|.||
Mouse 2513 PHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLK 2577
Fly 3584 ETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDD 3648
:|.|:.|||:||.||||||:|.::|:||||||||:|.:|||.||||||::||.:|||||||::||
Mouse 2578 KTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDD 2642
Fly 3649 NLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED--EK 3711
..||||||.|||||||||.|||||:|:|:.:.|.|||:|||||||::|||||||||||.|| .|
Mouse 2643 FDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNK 2707
Fly 3712 IPCSCGSKRCRKYLN 3726
:||:||:||||::||
Mouse 2708 LPCNCGAKRCRRFLN 2722
| 
