Protein Alignment trx and NSD2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001427822.1
• Gene: NSD2 / 7468
• HGNCID: 12766
• Length: 1398
• Species: Homo sapiens
• Alignment Length: 1499
• Identity: 273/1499 - (18%)
• Similarity: 442/1499 - (29%)
• Gaps: 545/1499 - (36%)

  Fly   646 PLSLGDSKGKNVFGTSSSSAGSTASTF----SASTNLKLGKETFFN---------FGTLKPNSSA 697
            |..||.:.||    |.|.......|.|    ..|::|:.|....||         ...||..:|.
Human    25 PEILGSANGK----TPSCEVNRECSVFLSKAQLSSSLQEGVMQKFNGHDALPFIPADKLKDLTSR 85

  Fly   698 AGNFVLRQP-----RLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGSLASTNSSTVTP 757
            ..|   .:|     :|:|::...:...|.|.   |:|.....|...|              .:|.
Human    86 VFN---GEPGAHDAKLRFESQEMKGIGTPPN---TTPIKNGSPEIKL--------------KITK 130

  Fly   758 T---------PSACSICSAVVSSKE------VTQAR-------KY------GVVACDVCRKFFSK 794
            |         .|.|...:|.||..|      ..:||       ||      |:|...:..|..|.
Human   131 TYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLEQGLVEAALVSKISSP 195

  Fly   795 MTKK-----------SISA----------------------NSSTANTSSGSQQYLQCKGNEGS- 825
            ..||           ::|:                      ..|..||.......|  |.|.|.
Human   196 SDKKVFRRRCVRGHVTLSSEHGHPMRAPARVLGRAEKIPAKKESCPNTGRDKDHLL--KYNVGDL 258

  Fly   826 -----------PCSI------HSAKSQLKNFKK--------FYKDRCTACWL-KKCMISFQLPAA 864
                       ||.:      || .::||..||        |:.|.....|: :|.:::|:
Human   259 VWSKVSGYPWWPCMVSADPLLHS-YTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFE---- 318

  Fly   865 HRSRLSAILPPGMRGEAAAREEKSAELLSP-TGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSA 928
            ...:...:.....: :|..:.|| .:||.| :|.||.............||.||:.:.:
Human   319 GEGQFEKLCQESAK-QAPTKAEK-IKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKA------ 375

  Fly   929 LTSIKPNPLAENNVTF---GSTPLLRPAILENPLFLKISNAADQKLAAAEAISPSLTKKNSKQEK 990
                        ..||   |....|.|.:            |.:...|||::..........:|.
Human   376 ------------KFTFLYVGDQLHLNPQV------------AKEAGIAAESLGEMAESSGVSEEA 416

  Fly   991 EKVKESEQSEKLLSPTQAGTKKSGAAEAQVEEVQPQ-KEEAPQTSTTTQPSASNGASHGVPQAEL 1054
            .:..:|.:.|.:  |.:...:....:.|:..|..|. .:..||.:....|....|:..|..:..:
Human   417 AENPKSVREECI--PMKRRRRAKLCSSAETLESHPDIGKSTPQKTAEADPRRGVGSPPGRKKTTV 479

  Fly  1055 AGETNATGDTLKR--------------QRIDLKGPRVKHVCRSASIVLGQ--------PLATFGE 1097
            :...:..||...:              :..|..|..::.:.||...:|.:        ..|....
Human   480 SMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASGEEIEELLRSQWSLLSEKQRARYNTKFALVAP 544

  Fly  1098 DQQPEDAADMQ-------QEIAAPVPSAIMEPSPEK----------PTHIVTDENDNCASCK--- 1142
            .|..||:.::.       :.|..|...|..|.:|.|          ....:||:....:|.|
Human   545 VQAEEDSGNVNGKKRNHTKRIQDPTEDAEAEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAME 609

  Fly  1143 ----------TSPVGDESKPSKSSGSAQAEVKKATALGKEGTASAA----------GGSSAKVTT 1187
                      |..:.|..||.|....|......|....|..:.||:          |...::...
Human   610 AASSLKSQAATKNLSDACKPLKKRNRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPY 674

  Fly  1188 RNAAVASNLIVAASKKQRNGDIATSSSVTQ-------------------------SSNQTQGRKT 1227
            .:|......:..:|||...|..|....|.|                         .|.:.:||.|
Human   675 ESADETQTEVSVSSKKSERGVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFT 739

  Fly  1228 KEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCAC--CCEPY 1290
                                ...|.:|.           ..||:|..:..| :..|..  |.:.|
Human   740 --------------------CSECASGI-----------HSCFVCKESKTD-VKRCVVTQCGKFY 772

  Fly  1291 HQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCP--RCTVCYTCNMS 1353
            |:.||: :|.|                 ||..|.|             :.||  .|..|:..|.|
Human   773 HEACVK-KYPL-----------------TVFESRG-------------FRCPLHSCVSCHASNPS 806

  Fly  1354 S-----GSKVKCQKCQKNYHS--TCLGTSKRLLGADRPLICVNCLKCKSCSTTKVSKFVGNLPMC 1411
            :     |..::|.:|...|||  .|       |.|...:|..|.:.|.:..|.:..|........
Human   807 NPRPSKGKMMRCVRCPVAYHSGDAC-------LAAGCSVIASNSIICTAHFTARKGKRHHAHVNV 864

  Fly  1412 TGCFKLRKKGNF--CPICQRCYDDNDFDLKMME----CGDC------------------------ 1446
            :.||...|.|:.  |..|...:..:..:::|.:    |.||
Human   865 SWCFVCSKGGSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPA 929

  Fly  1447 -------------------GQ------------WVHSK-----CEGLSDEQYNLLSTLPESIEFI 1475
                               |:            |.|..     .||....:|..:..:....:..
Human   930 EVCHPKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKNA 994

  Fly  1476 CKKCARRNESSKIKAEEWRQAVMEEFKASLYSVLKL---LSKSRQACALLKLSPRKKLRCTCGAS 1537
            .::...|....|::.|. |:....|.|...|..:|:   ..|.:...|.:...|    :|.|..:
Human   995 LQEAEARFREIKLQREA-RETQESERKPPPYKHIKVNKPYGKVQIYTADISEIP----KCNCKPT 1054

  Fly  1538 SNQGKLQPKALQFSSGSDNGLGSDGESQNSDDVYEFKDQ-----QQQQQQRNANMNKPRVKSLPC 1597
                            .:|..|.|.|..|...::|...|     :..|.|.......|..|.:.
Human  1055 ----------------DENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIK- 1102

  Fly  1598 SCQQHISHSQSFSLV---DIKQKIAGNSYVSLAEFNYDMSQVIQQSNC-------DELDIAYKEL 1652
                  :..:.:.||   ||::....|.||         .::|.:..|       .|.||.:..:
Human  1103 ------TDGKGWGLVAKRDIRKGEFVNEYV---------GELIDEEECMARIKHAHENDITHFYM 1152

  Fly  1653 LSEQFPWFQNETKACTDALEED-MFESCSGGNYEDLQDTGGVSASVYNEHS----------TSQA 1706
            |:                :::| :.::...|||           |.:..||          |...
Human  1153 LT----------------IDKDRIIDAGPKGNY-----------SRFMNHSCQPNCETLKWTVNG 1190

  Fly  1707 ESRSG---VLDIPLEEVDDFGSCGIKMRLDTRM-CLFCRKSGEGLSGEEARLLYCGHDCWVHTNC 1767
            ::|.|   |.|||         .|.::..:..: ||          |.|..:..||     .:||
Human  1191 DTRVGLFAVCDIP---------AGTELTFNYNLDCL----------GNEKTVCRCG-----ASNC 1231

  Fly  1768 AMW-------SAEVFEEIDG--SLQNVHSAVARGR-----MIKCTVCGNRGATVGCNVRSCGEHY 1818
            :.:       |..:..|..|  :.:......|:|.     ..:|..||:.|..|.|:.:.|.:.|
Human  1232 SGFLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCTKAY 1296

  Fly  1819 HYPC 1822
            |..|
Human  1297 HLSC 1300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390	35/172 (20%)
		PRK13914	<1006..>1224	CDD:237555	49/305 (16%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	18/79 (23%)
		PHD	1346..1390	CDD:214584	13/50 (26%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	12/121 (10%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	23/100 (23%)
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781
		SET_KMT2A_2B	3575..3726	CDD:380947
NSD2	NP_001427822.1	None