DRSC/TRiP Functional Genomics Resources

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Protein Alignment trx and setd1ba

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001038599.2 Gene:setd1ba / 567970 ZFINID:ZDB-GENE-050309-289 Length:1844 Species:Danio rerio


Alignment Length:2055 Identity:417/2055 - (20%)
Similarity:688/2055 - (33%) Gaps:627/2055 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2077 QNQNQQAGGANSV-----SICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWP 2136
            :.|..|..|...|     .:.::..|..::||.||...|:|:   ..|..:.|...:..|.:..|
Zfish    12 KRQKPQTRGTQYVPGERNKLNEDHGRRQSSSLANGMDNSHPI---CSSGEKRSHHWRSYKLIIDP 73

  Fly  2137 KL----------DGN--------------------SAMATAIKR--------------------- 2150
            .|          ||:                    ..:.|..|.                     
Zfish    74 ALKKGSHKVYRYDGHQFSTPSFGMSPVDIVRDPRIGRLWTKYKETDLPVPKFKIDECYVGRVPPK 138

  Fly  2151 ----RKLSKNLAEGVFLT-------------LSSQQRNKKEMATVAGVSRRQSISETSVEGVATT 2198
                .||:.|:.|| |||             :....:|||.:.....|......::.:|:.:..|
Zfish   139 EVTFAKLNDNVREG-FLTDMCKKFGDIEEVEILYNPKNKKHLGIAKVVFETVKAAKDAVQNLHNT 202

  Fly  2199 S--GSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQV 2261
            |  |::......        .|.|.|:     |..|           |:|:|.....|....|:.
Zfish   203 SVMGNIIHVELD--------PKGENRQ-----RYFQ-----------RLINGSYTPLTLPVGGEE 243

  Fly  2262 KCD-----------RCQCTYRNYDAFQRHLPSCSPTMSSNETESDV------------------- 2296
            .||           .|:.:.|.::.....:...:|:.::.....|.                   
Zfish   244 ACDVSPRSLAEALMACEPSRRLFEGGSSVVAGTTPSGTNTPMSLDTAYSSLRQDTPQSQGTPHTP 308

  Fly  2297 --SGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSF-------PQVQSLGSLGQFGLQG 2352
              ||...:.:::..|.:.....|.....::||....:..|.|       |:.:.:....|.|  .
Zfish   309 RPSGTPFSQDSSYSSRQGTPAFQANRAESSGGYKSRRHETKFQDAYNRRPERRYVHGPTQRG--N 371

  Fly  2353 LQQ----LQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQ 2413
            .:|    .|.||....|..|...|.|.|                 :||....::..||.:     
Zfish   372 TEQPPSFKQHQPPEPPSPAFTHTPPPPT-----------------SANFKTAYSQYQPPI----- 414

  Fly  2414 PQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQ 2478
            ||...|::.....|:.:...:..||...|:..:..::...|...|..|..|.    :|..|    
Zfish   415 PQEYTVASYHQPVQRELDYRRPPQAPPPPSTDFLPVRDRPTTPPIPEPPPAP----ETQPT---- 471

  Fly  2479 QAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQ 2543
                           .|..:..:|.|...|:.::..:...|    :.||:|.|..:..:..:   
Zfish   472 ---------------TPPSSTPEPCPSPTQESERNSLDSRI----EMLLKPFLNERGDSDAE--- 514

  Fly  2544 IILPQAQPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQP------QPTATPTFLTTAPGAGATY 2602
             :.....|      ::...||..|     ||.....:|..      .||..|......|..|...
Zfish   515 -VRMDGSP------ISSSSSQLSP-----IPPQRPSRPSSTGLEDISPTPLPDSEDDEPIRGTAS 567

  Fly  2603 LQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILG 2667
            |..::.|     .:|:|     :.::|...:|:   |.|...                       
Zfish   568 LLANSRG-----MSPTN-----MHSKSCVGEPR---TAIDKM----------------------- 596

  Fly  2668 GTGGGSSGLEFATTSPQVILATQPMYYG--LETIVQNTVMSSQQFVSTAMPGM--LSQNASFSAT 2728
            .||..|||.:...:..:  :...|:..|  .:.||.|:.:|..|.:....||.  |...|.|...
Zfish   597 DTGHQSSGEDMEISDDE--MPGTPIASGDCDKNIVVNSALSLIQTIPMPPPGFPPLPHAAGFPLP 659

  Fly  2729 TTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTF----LNAASVLQQ------QTQDDTTTQIL 2783
            ...:...|.:.   .||:.:.:|:   ...|.|..    ::..|.|.|      |.|....:::.
Zfish   660 PHHLPHHSTVS---HLPSHHPMLH---PLHSYGMMHFLPVDLLSSLPQLLQMPFQMQTQMLSRMA 718

  Fly  2784 QNANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGV-----------G 2837
            |:.:......|..|....:|.:..|      .||::.:     .|.|..:.|.           .
Zfish   719 QSQHPYAYPYPAPSANPAAMPFGGP------YPPLSVV-----SAPADTLHGQPWPLPSMPQFNP 772

  Fly  2838 KVPP---QPQ-------VVNKVLPTSIVTQQSQVQVKNSNLKQSQV------------KGKAASG 2880
            .|||   :||       .::.|| .:||.:...:..|:.|.|..:|            :..:|..
Zfish   773 AVPPPGYEPQKEDPHKATIDGVL-MAIVKELKAIMKKDLNRKMVEVVAFRKFDEWWDKQELSAKA 836

  Fly  2881 TGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSL---------------- 2929
            |.|           |:  ||...:...|...|||....:....|:...|                
Zfish   837 TLT-----------PV--KTGEGKDEEKERAKPKETMSSHLPWNKGEGLGFEGMGLGIGLRGIRL 888

  Fly  2930 --LQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRI-PAQTQQQQLQQAQMIHIPQQQ-------- 2983
              .:.:::|.|:             |..|...:|: |:.....:|:..:...:.:..        
Zfish   889 PSFKVKRKQPPE-------------PTSTSDNKRVRPSTPVDDELEDEESERMGRTDGSRVDPAG 940

  Fly  2984 --------QPL-------QQQQVQVQPSMPIITLAEAPVVQ-SQFVMEPQALEQQELANRVQHFS 3032
                    :||       ::::...:....:....|.||.. |:.:...:.||:::......|.|
Zfish   941 SSSKRRPARPLELDSEGEEEEETSGKEESSLSDHEEEPVDDASERLSSGKDLEEEDEKKSESHSS 1005

  Fly  3033 TSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTN-----------RVLPMQQRQE------- 3079
            .|.||.||:....::..:.....:..:.|||....::           |::.|...::       
Zfish  1006 ESESSDSSDDEASSSSSSKSGSDSSGSESSSDYESSSEEEEEEEEEEERIVGMDDEEDVDARTST 1070

  Fly  3080 -----PAPLSNECPVV-----SSPTPPKPVEQP-------------IIHQMTSASVSKCYAQKST 3121
                 ....|:|..||     |:||.|.|.|:|             |.|:.:..|:.|...::..
Zfish  1071 SSSTTSTSSSDEEEVVEVKAPSTPTGPPPEEEPNELGRLEAVDEAEIDHKPSMVSLIKTKVEEVR 1135

  Fly  3122 LPSP--VYEAELKVSSVLESIVPDVTMDAILEE-----------------QPVTESIYTEGL--- 3164
            .|||  :...||.|.  ||..:|....:|.|||                 |.....|.||..   
Zfish  1136 PPSPKGLPADELDVD--LEVKIPVPKTEASLEEVGNLRPPTPTGSFADSDQDTRPKIPTEDFPRT 1198

  Fly  3165 --YEKNSPGESKT--EQLLLQQQQREQLNQQLVNN--GYLLDKHTFQVEPMDTDVYREEDLEEEE 3223
              :|...|.||:|  .:.|........|....|.:  ..|....|....|:...:..|||:....
Zfish  1199 PGHEGPVPLESETTVPRSLPTPSMHLPLPPSHVPDPQSLLPPPETLPDMPVRGRLPTEEDIPRTP 1263

  Fly  3224 DED----------------------DDFSLKMATSACNDHEM-SDSEEPAVKDKISKILDNLTND 3265
            ..|                      .|..| ...|..:.|.: |....||....:|..:......
Zfish  1264 GRDLMDRARGLGKLQSTDTVPVTPGSDTPL-TGNSLSSPHILGSPFSYPAQSPVLSAGIPRTPGR 1327

  Fly  3266 DCA------DSIATATTMEVDASAGYQQMVE-----DVLATTAAQ-----SAPTEEFEG-ALETA 3313
            |..      ||...:..:.:...|..:.:.|     :.|.:.:.|     :|.:..|.| .|.||
Zfish  1328 DLTFAPAFPDSAGLSAGLPIHRKASSEILEEKPLFKEPLLSASPQASLPNNAASSPFPGPPLPTA 1392

  Fly  3314 AV-EAA--------ATYINEM-ADAHVLDLKQLQNGVELE-------LRRRKEEQRTVSQEQEQS 3361
            :: |.|        |:..|.. |....|.:..:...|.|:       |.|.|.::..  |:.|:.
Zfish  1393 SLPEPALPPQGSPPASIENSFPASPKELPVPMIDVPVPLDDTPSKKKLVRSKNKKGI--QDSEEP 1455

  Fly  3362 KAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDG---FTYKSSS-----ITEIWEKVF---E 3415
            :..::..::.||.|...|.|...:     ..|:.|||   |:.|..|     |.::.|..|   |
Zfish  1456 QVTLIEASSLPELPVNNQYPDLPS-----ESIKEEDGEPAFSEKEESQVPTIIPKVEETSFYVEE 1515

  Fly  3416 AVQVARR-----------AHGLTPLPEG----PLADMGGIQMI------GLKTNALKYLIEQLPG 3459
            .:|..||           .|.....|..    |.:|...:.::      |:....::||      
Zfish  1516 PIQKTRRQRRGWQELLLSMHSPVASPRRPSFMPRSDFEEMTILYDIWNDGIDEEDIRYL------ 1574

  Fly  3460 VEKCSKYTPKYHKRNGNVSTAANGAHG------------GNLGGSSASAALSVSGGDSHGLLDYG 3512
                 |.|  |.|     ....:.||.            .|:|.::.              :...
Zfish  1575 -----KIT--YDK-----MLQQDNAHDWLNDTLWVHHPPTNMGSATG--------------VKKK 1613

  Fly  3513 SDQDELEENAYDCARCEPYSNRSEYDMFSWL-ASRHRKQPIQVFVQ----PSDNELVPRRGT--- 3569
            ..:|.:.::...|||.|.|....:.|...:| :||.:.:...|..|    |:..::..|.|:   
Zfish  1614 RKEDGIRDHVTGCARSEGYYKIDKKDKMKYLNSSRLQSEEPDVDTQGKSIPAQPQVSTRAGSERR 1678

  Fly  3570 ------------GSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELI 3622
                        .|:|   :|:..|| ..|..:...|||||..||:..:.|.|.||||||.|:.|
Zfish  1679 SEQRRLLSSFSCDSDL---LKFNQLK-FRKKKIRFCRSHIHDWGLFAMEPIAADEMVIEYVGQNI 1739

  Fly  3623 RSTLTDKRERYYDSRGIG-CYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHII 3686
            |..:.|.||:.|:..||| .|||::|.:.::|||..||.||||||.|.||||:||:.:...|.|:
Zfish  1740 RQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIV 1804

  Fly  3687 IFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3726
            |::.:.|...||:|||||||.|||||||.||::.||..||
Zfish  1805 IYSRQPINVNEEITYDYKFPIEDEKIPCLCGAENCRGTLN 1844

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390
PRK13914 <1006..>1224 CDD:237555
PHD1_KMT2A_like 1268..1344 CDD:276981
PHD 1346..1390 CDD:214584
PHD3_KMT2A_like 1423..1479 CDD:276983
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1890..1937 CDD:461787
FYRC 3388..3476 CDD:197781 25/119 (21%)
SET_KMT2A_2B 3575..3726 CDD:380947 75/151 (50%)
setd1baNP_001038599.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..58 10/42 (24%)
RRM_Set1B 136..228 CDD:409965 22/116 (19%)
PABP-1234 <145..333 CDD:130689 35/212 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..288 1/18 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..562 56/332 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 838..871 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 890..1108 38/230 (17%)
PHA03247 <1136..1500 CDD:223021 78/373 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1160..1341 34/181 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1367..1499 32/138 (23%)
N-SET 1556..1699 CDD:463344 29/177 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1647..1678 7/30 (23%)
RxxxRR motif. /evidence=ECO:0000250|UniProtKB:P38827 1678..1683 0/4 (0%)
SET_SETD1 1693..1840 CDD:380946 74/150 (49%)
Blue background indicates that the domain is not in the aligned region.

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