DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and kmt2bb

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	XP_002664717.2	Gene:	kmt2bb / 566825	ZFINID:	ZDB-GENE-080521-1	Length:	3772	Species:	Danio rerio

Alignment Length:	4568	Identity:	1003/4568 - (21%)
Similarity:	1533/4568 - (33%)	Gaps:	1664/4568 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSKFPGKPSKSINRKRISV--------LQLEDDAANPAEPQQP----APESQQPSGSGSGSSAAR 55
            |.:|||:|..|.:|.|...        ..|::.:|| ..|:..    ||...||.....|..|:.
Zfish    25 RGRFPGRPWSSRSRLRSEKRWQLGRCGTDLDEISAN-GGPRPTCLVLAPNEDQPLSRLLGLEASY 88

  Fly    56 EKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSSGSSTGSGSSGSGSTNGGSVNGGTHH 120
            ::                            .|.:|. |||||..||...|....|   .|.....
Zfish    89 KR----------------------------LGEAGY-SSSGSEEGSEFKGFEVQN---ENRSIPV 121

  Fly   121 KSAANLDKEAVTKDQNGDGDKTRGNVSSAPSGKLSAAA-------------------SGKALSKS 166
            ::..|..|              ||.||...|.::....                   ||......
Zfish   122 RAGRNPCK--------------RGRVSVKSSKRIRQRLALPVSPLVESTGSHDPQNDSGTVQQLH 172

  Fly   167 SRTFSASTSVTSSGRSSGSSPDGNSGASSDGASSGISCGK--STAKSTEASSGKLAKTTGAGTCS 229
            |:.....|||...|...|...|      .|||....:..|  |..:.|:.:.....|.....|..
Zfish   173 SQESQKDTSVDDGGGGGGGGDD------VDGALEKPTRRKRGSRKRETQTTPRITIKLVAKKTVV 231

  Fly   230 SAKSSKASSG--------TTSEATTSGLSGACLKALFVATPATSTGLACALVSPGGSSQGGTFPI 286
            :..:.:...|        ..||:..:.:|.|.:| |...|||:.            ||.|.| .:
Zfish   232 TVPTLRRKPGRRPKEVKTEVSESQCAQISSAHVK-LKTKTPASE------------SSAGDT-KV 282

  Fly   287 SAALLRARKNSNKKFKNLNLARGEVMLPSTSKLK-QLNSPVVDNPSPSPPIASGSTPSVEGGIGV 350
            .....|..:::::|.:. .|.:......:..||| :.::....||.||    ....|
Zfish   283 EVCTRRRGRSADQKLET-TLQKEPKKEANDQKLKLRKSTRKCQNPLPS----ENKEP-------- 334

  Fly   351 GGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAANGAASGKGSASNGPPAMASSGDGSSPKSG 415
                .|.:.:|  :..:|:...|.|.....|..|          ...:|..::|.|   ....|.
Zfish   335 ----KPADKSA--QEASEVNKLVIRRQRTRSSIA----------PQESGDQSLAES---QLEVST 380

  Fly   416 ADTGPSTSSTTAKQKKTVTFRNVLETSDDKSVVKRFYNPDIRIPI------VSI--MKKDSLNRP 472
            .|...|.|....|:||....|...|.:.|.|.....::.|..:.:      |.|  :|...:..|
Zfish   381 IDESRSPSKKKKKKKKKKKNRKESERNKDSSAKDHGHSADDPLKLAFGNDFVGIPGLKLTRIRNP 445

  Fly   473 LNYSRGGEC-IVRPSILSKILNKNSNIDKLNSLKFRSAGASSSSSNQES-GSSSNVFGL------ 529
            ...||...| .|....|.|...|:|:|.:       :...:....|||. |.:..:...
Zfish   446 KARSRKKRCKFVWTLTLVKCKGKDSHIQE-------NLSKTQDPQNQEDLGKTQEIESQDSRVQK 503

  Fly   530 --SRAFGAPMDE-------DDEGGVTFRRNDSPEDQNNAEDDEMDDDDDDEEA-----EEDDEN- 579
              |:|..:|..|       |.|..|:.....:....:..|.|.:.:....|..     .|..||
Zfish   504 SPSKADESPSIEAELPPKCDKEVDVSEEAEPASAPSSTLETDSLQESQKVENTASTVIPESPENP 568

  Fly   580 -EDDNDEAVSEKSAE-----TEKSAGADERDPDEKQLVMDSHFVLP---------------KRS- 622
             ..|.||.:.||..|     :|..|..:|....|.:.:::...|.|               |:|
Zfish   569 VAIDKDEEIPEKENEEVLERSEIEAHPEEATQTEPEDLINKDIVPPLQIKVVSSPGKNNSLKQSF 633

  Fly   623 -----TRSSRIIKPNK----RLLEEGAISTKKPLSLGDSKGKNVF-------------------- 658
                 |.|..|.:|.|    :.||......:|..:..|.|.:|..
Zfish   634 LIQQVTTSPEITEPEKVEEHQHLENSENMLQKTTTSPDHKVRNKLHQSAARKKRARHRHWTIYRR 698

  Fly   659 -GTSSSSAGSTASTFSAST-----------------------------NLKLGKETFFNFGTLKP 693
             |.::.|..::||..:..|                             ..|.||.:.  ..|.:|
Zfish   699 KGRTNPSQENSASEIATETEPQEEELLVLPTEVPAPVESKPKRHLDKITPKRGKRSV--PPTAEP 761

  Fly   694 NSSAAGNFVLR----------------QPRLQFQA---DNQQATFTAPKACPTSPSAIP-----K 734
            ...||...|:.                ||.::.:|   :|::.....|..........|     |
Zfish   762 LPEAAEPQVIEQTVEAPSTDLLPVTEPQPEIKLEAPSIENEEVLVLEPSVKDHPQVRRPLKRRIK 826

  Fly   735 PANSLATSSFGSLAST----NSSTVTPT-------------PSACSICSAVVSSKEVT-----QA 777
            .|.....|..|.....    ....|.||             |....:.:.....|.:|     :|
Zfish   827 HAKRRRRSLIGRRVKNQKLQKKVLVEPTDGCPPTTESEGGEPKLVGLFATKYKRKRITSIQSLEA 891

  Fly   778 RKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQCKGNEGSP-------------CSI 829
            |:...       ||.||..:.:.|.:..:....|.|......:.::..|             ..:
Zfish   892 RRKKA-------KFLSKQLENTSSQDQLSTQEESDSFSVKTDQDHDIQPNKAKIVKNIRHFIMPV 949

  Fly   830 HSAKSQ--LKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSAILP------PGMRGEAAAREE 886
            .||:|.  :|..|:|..|          :....||..:..:...:.|      |..|||....:.
Zfish   950 VSARSSRVIKTPKRFMDD----------LGMSDLPRKNSQKKLGLQPKSKKSDPSERGEPGCFQS 1004

  Fly   887 KSAELLSPTGSLRFTSTASS--SSPSVVASTSVKWKSSGDSTSALTSIKP-------NPLAENNV 942
            :..|.......|..:||..|  .||..:...|.: |.||...|.|..  |       .|.:|:..
Zfish  1005 QDEEDNQSEIDLDLSSTWESKPKSPDDIDLFSEE-KQSGKRRSLLRD--PGFKWGVLEPASEDVY 1066

  Fly   943 TFG-----------------------------STPL------LRPAILENPLFLKISNAADQKL- 971
            :||                             ||..      ||   |...|.||.|.|..:|:
Zfish  1067 SFGEDLDKELETLLSAKDFTVDSFLDPVQKKKSTKFKAQSSKLR---LYKKLKLKQSLARQKKIP 1128

  Fly   972 -------AAAEAISP--------SLTK--KNSKQEKEKVKESE----------------QSEKLL 1003
                   .::.|.:|        ||.|  :..|:||.|:|..:                .|.|||
Zfish  1129 KEKISKVVSSPAKAPKKELEEGASLIKSLREMKKEKAKLKIEDLNTPGVVRKVSICVRALSAKLL 1193

  Fly  1004 SPTQAGTKKSG---------------------------AAEAQVEEVQPQKEEAP-QTSTTTQPS 1040
            :..||...:..                           .:||.|.| .|:|.:.. :....:|..
Zfish  1194 AQHQAKDIQEDDLPDEFSIHTDISLPNKCKDFDKLHLTESEAPVSE-DPEKHDVDVEEKNASQRP 1257

  Fly  1041 ASNGASHGV---------------PQAEL-------AGETNATGDTLKRQRIDLK---------- 1073
            ...||:..:               .|.:|       .|...||    ||||...|
Zfish  1258 RLTGANKRMFNLLKKAKVQLIKIDQQKQLKSSGLLPEGRITAT----KRQRRKPKERPVKACPNK 1318

  Fly  1074 ------------GPRVKHVCRSASIVLGQPLATFGEDQQPEDAADMQQ--EIA-APVPSAIMEPS 1123
                        |||:|||||:|::|||||.|...:|.....|..:.:  :|: :|....:...|
Zfish  1319 TEATPEQEPARGGPRIKHVCRAAAVVLGQPRAMVPDDIPRLSALPLHERSDISPSPAEKGVESHS 1383

  Fly  1124 -PEKP--------------THIVTDENDNCASCKTSPVGDE--------SKPSKSSGSA------ 1159
             ||.|              :|:....:..|..||.....::        .||.....:.
Zfish  1384 DPESPVLQEHRTPKFRRGRSHMFGHRSRRCGECKGCLHEEDCGRCINCLDKPKFGGPNTKRQCCV 1448

  Fly  1160 -----QAEVKKATAL--------GK--------------EGTASAAGG-----------SSAKVT 1186
                 |.|.:||..|        ||              ||.|....|           |..|..
Zfish  1449 YKRCDQVEERKALRLSGKLQKGHGKKRRPSVSVYYSSNEEGEAGEGNGRMFPSSLSDSPSVRKQP 1513

  Fly  1187 TRNAAVAS--NLIVAASKKQRNGD---IATSSSVTQSSNQTQG---------------------- 1224
            .|:....|  :|:      ..:.|   |.:|:|.:....:|.|
Zfish  1514 RRHVTPRSYCDLL------DYDSDFDWIGSSNSASPGRRRTPGLRNPDFLSFDDFIGDPFDEGVR 1572

  Fly  1225 -------------RKTKEHRQQRT------------------------LISIDFWENYDPAEVCQ 1252
                         ||.::..|::|                        .|.:||.|:.....|..
Zfish  1573 HRRPGFHKVPTIKRKVEKSPQEQTPPSVLAALANGFAEREQEPAEPTYKIRVDFKEDCSVQSVWA 1637

  Fly  1253 TGFGLIVTETV--AQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSL 1315
            || ||.|..:|  ....:|.||.|.|...::||..||||:|::|
Zfish  1638 TG-GLSVLTSVPLMPSCVCLLCASKGQHEMLFCQVCCEPFHRFC--------------------- 1680

  Fly  1316 LETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTC---NMSSGSKVKCQKCQKNYHSTCLG---- 1373
                ::.|..|...     .:.||.|.||..|..|   |..|...::|::||..||..|||
Zfish  1681 ----LDPSERPLEE-----NKENWCCRRCKFCRVCGRKNKESKPLLECERCQNCYHPACLGPNYP 1736

  Fly  1374 -TSKRLLGADRPLICVNCLKCKSCSTTK----VSKFVGNLPMCTGCFKLRKKGNFCPICQRCYDD 1433
             .:||    .:|.:|:.|::|:||..|.    .:::..:..:|..|.:|..:||:|.:|.:||:|
Zfish  1737 KPNKR----KKPWVCMTCIRCRSCGVTPGKSWDTEWNHDKGLCPDCTRLFDQGNYCTMCFKCYED 1797

  Fly  1434 NDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRN-ESSKIKAEEWRQAV 1497
            ||:|.:||:|..|..|||:|||||:|:.|.:||:||||:.:.|:.|.:.. :...:....||:.:
Zfish  1798 NDYDSQMMQCSTCNHWVHAKCEGLTDDLYEILSSLPESVVYSCQPCLKEQPDGEAVSGAGWRELL 1862

  Fly  1498 MEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQFSSGSDNGLGSDG 1562
            .:|.:..|..:|..:..|.....|:...     :|:...|||.|
Zfish  1863 DQELRTGLERLLSCMMGSTVTQHLVTCK-----KCSTLGSSNIG--------------------- 1901

  Fly  1563 ESQNSDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLA 1627
                                         |:.||. |          .|..|.:|..|..|.||.
Zfish  1902 -----------------------------VEELPI-C----------DLSAIGKKFEGGHYTSLK 1926

  Fly  1628 EFNYDMSQVIQQSNCDELDIA-------------YKELLSEQFPWFQNETKACTDALEEDMFESC 1679
            .|:.|:.:|::: ..:|.::.             |..||.:.:.||.::.....|...:.:
Zfish  1927 SFHEDVVKVLRR-YLEEEEVLPEDQKHTALARSYYLTLLEDVYGWFNSQDPKLWDPRSKHL---- 1986

  Fly  1680 SGGNYEDLQDTGGVSASVY---NEHSTSQAESRSGVL-----------DIPLEEVDDFGS----- 1725
                     ..|.:|.:|.   .||..:|...|...|           |:.:.:.:|..|
Zfish  1987 ---------PAGMLSHAVMPPNYEHVYAQWRERDKALDGNLQLTGRHADVKMGDEEDLPSHLANM 2042

  Fly  1726 --------CGIKMRL-------------------DTRMCLFCRKSGEGLSGEEARLLYCGHDCWV 1763
                    ..::|.|                   |.|.|..|:|.|:..:.:..||||.|.:.|.
Zfish  2043 QKGHLMDMRALRMNLKGKKSRQGKSDLETGWSKDDERQCALCQKYGDAKASDAGRLLYLGQNEWA 2107

  Fly  1764 HTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDC 1828
            |.||:|||||||||.:|||.:|||||||||:::|..|...||||||.:.||..:||:.|||..:|
Zfish  2108 HVNCSMWSAEVFEEDNGSLLHVHSAVARGRLMRCERCNRTGATVGCCLSSCQSNYHFMCARFRNC 2172

  Fly  1829 AFLTDKSMYCPAHAK--NGNALKANGSPSVTYESNFEVSRPVYVE---LDRKRKKL--IEPARVQ 1886
            .|..||.::|..|..  :|..:...|         |||.|.|||:   :..:||.|  :||..:.
Zfish  2173 VFQDDKKVFCYKHRDLISGKMITGQG---------FEVLRRVYVDFEGISLRRKFLTGLEPESIN 2228

  Fly  1887 FHIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEPWKIVEYTVRTT----------IQ 1941
            ..||||.|.:||.: ...|.....:.|:.:.|||.:||:..|.:..:||.|.|          ::
Zfish  2229 LMIGSLLVEKLGKL-SELSACDGKLFPVGYECSRWFWSTVNPLRRCKYTFRVTEVRPAVQEKQVE 2292

  Fly  1942 NSSSTLTALDVGRNYTVDH-----------------TNPNSK----------EVQLGM------- 1972
            .|.      |.|.|.|:.|                 |||:::          :..||.
Zfish  2293 ESP------DHGENCTIAHSPCPQSECEALELGLSSTNPSTEANFTSGSVFAKPDLGARPKITSY 2351

  Fly  1973 ------------------AQIARWHTSLARSEF------------LENGGTD---WSGEFPNPNS 2004
                              |..::.|..|..|:.            .:|.||.   .|....:|..
Zfish  2352 PQNRRPAGGLSRPLPSPGAAPSKPHHILTISDLEDTRRPRRHSPHTQNSGTRSHMTSPTLGSPAG 2416

  Fly  2005 CVPPDENTEEEPQQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDGTQ 2069
            .:|........|:......|               :..:...:..|..........|..|..||.
Zfish  2417 PIPSRAGGSHHPKSSQTTSP---------------MFPLGATENLLTSSSARPVGRSASSVRGTG 2466

  Fly  2070 AMTSNQAQ---NQNQQAGGANSVSICDEDTRNSNTSLGNGWPAS---NPVEDAMLSAARN---SS 2125
            .:|.:...   :|:.:.||..|.. |...:..|.|.|... |..   ||::.  |....|   |.
Zfish  2467 ILTPHSTSGLFSQSTKQGGIGSTP-CTNRSLTSPTHLSTR-PRPFDFNPIDS--LELPHNFIASP 2527

  Fly  2126 QVQMLKT--------LAWPK----------------LDGNSAMATAIKRR-KLSKNLA-EGVFLT 2164
            |..:.:|        |:.||                |:.:..:|..::.. ::.:::. |||.:.
Zfish  2528 QEHLSETGALPLGDALSMPKVNHLCSDRDFPYTSIHLEADLTVAPELRTELEIEESVVNEGVAMN 2592

  Fly  2165 LSSQ---------------QRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSK-------SF 2207
            .|:|               ..||.:|:     |:|.|   .:|:......|:..|.       :|
Zfish  2593 CSAQIVVEGEDNQEDFWEPDDNKSKMS-----SQRLS---CTVDPCREDWGNSSSDEDMENYFNF 2649

  Fly  2208 TWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRN 2272
            |.:......::...::..:..:|.|:|||||. ||     .|.:|:.:........::.|..:::
Zfish  2650 TRTVVTCKAQRDSSKKSPSVRQISQLDGVDDG-TE-----SDTSLANSDNHAMKLSNQTQKPHKS 2708

  Fly  2273 YDAFQRH----------LPS----------CSPTMSSNETESDVSGQGMTNNATQISAESLNELQ 2317
            ..|....          .||          |..::.::|..:|....|:|
Zfish  2709 LSAVPHEQTASNGLCLTFPSPLSDISSINCCFESVPNSEVLTDQDSFGLT--------------- 2758

  Fly  2318 KQLLANAGG---------LNYLQSATSFPQVQSLG----SLGQ---------------------- 2347
             |:|.::.|         :|:::|.:|.|...:.|    ||.:
Zfish  2759 -QILESSSGVCGPQQDTLINFVESKSSNPTFSTYGNDYQSLAEPETPLILERCDPLSPNAHFTEL 2822

  Fly  2348 -------FGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANS-LQSLAANL----GGG 2400
                   ...|..::|.|.|   .||.|:|        :.||..:|.|| ||..:.||    |..
Zfish  2823 VPVQDSPCDPQESKELYLDP---SSGHFVS--------SVDDATVYQNSHLQDDSLNLNQVNGIQ 2876

  Fly  2401 FTLAQPTVTA-----PAQPQLIAVSTNPDGTQQ--FIQIPQTMQATTTPTATYQTLQATNTDKKI 2458
            |:|.|..|.:     || |.|     .|..:.|  |:..|.    .||||........|:..|.|
Zfish  2877 FSLQQNPVPSTELLKPA-PLL-----EPSSSVQVPFVAFPN----QTTPTNVSLFPVQTSAGKTI 2931

  Fly  2459 MLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMG 2523
            :.|:                               :..:.||.|||:|..
Zfish  2932 LPPM-------------------------------ESFRTKLNPHPEQRH--------------- 2950

  Fly  2524 QNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTGDGSQGQPLQYISIPTA-----GEYKPQP 2583
                            .||.:      |...:.:|..:..| :|...:|:|:|     |.|.|..
Zfish  2951 ----------------PAPSV------PGGALPYVPANIPQ-KPESMLSVPSATGVPLGTYGPIS 2992

  Fly  2584 QPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQL 2648
            ...:.|...|.....|:|.:...:|...| |:.||             ||.|.:.:.|||
Zfish  2993 GTVSVPLHPTYMQPIGSTTVGVVSSSTSV-TSQPS-------------AQCQAMPSAIQP----- 3038

  Fly  2649 GGGADGNQP----GSNQQPLILGGTGGGSSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQ 2709
                 .:.|    |.|..|:......|.:..:.|:|.                   ::.|...||
Zfish  3039 -----ASAPCVINGYNTMPMQRDSAPGRTISINFSTP-------------------RSAVEPQQQ 3079

  Fly  2710 FVSTAMPGMLSQNASFSATTTQVFQASKI-EPIVDLPAGYVVLNN------------------TG 2755
            .|:.|:||            ..:....:: .|.|| |..:|:|.|                  |.
Zfish  3080 LVTQALPG------------HAILTVKEVGGPNVD-PTPHVLLVNRLGQIFVKNPESNTFQLPTP 3131

  Fly  2756 DASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSMDYTSPVMVTAKIPPVTQ 2820
            ::.|.......||:||......|    |..|.    |:|..:||      |.|..|:..:.|:.|
Zfish  3132 NSPSFSCVTQIASLLQSNALSAT----LAAAG----SLPAVAGA------TIPTQVSHIVTPLVQ 3182

  Fly  2821 IKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTC 2885
            ...|..|..|...:..  .||.|..|.|               ...|.|.:..|.|
Zfish  3183 TSNTITQLLATNNNEA--APPPPADVKK---------------PRRNTKSTGEKVK--------- 3221

  Fly  2886 GAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVN 2950
                    ||..||.:.         .|:..|.|.....|:...:.....:..||..  ...::|
Zfish  3222 --------KPRTKKESS---------TPRRTKSTSTSGKQSTGQVITSSDKFNQLDS--AQAIIN 3267

  Fly  2951 QV------PKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQ 3009
            |.      |..|:| ..:|:.:             |...:|:.|.|..|.|.:|
Zfish  3268 QAMAGYYDPNKTVS-NILPSSS-------------PCNTKPVGQTQTTVSPVLP----------- 3307

  Fly  3010 SQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRP------- 3067
                                               .|.:|.|.::.:|..|.....||
Zfish  3308 -----------------------------------ETLLVKPEKKSSPPVTPEVAPRPKQVRMKR 3337

  Fly  3068 ----TNRVLPMQQRQEPAPLSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYE 3128
                ::|:...:.:.:...:..          |..:|:|  |:.:|.|.|: |..:...|:
Zfish  3338 VSCLSDRIATKKSKSDFLDMER----------PSALEEP--HKSSSVSASR-YGVRIKTPT---- 3385

  Fly  3129 AELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLV 3193
                |..:|:       :|. |.|:|.::|       |...||  ..::|.|.:.....
Zfish  3386 ----VKGILD-------LDK-LNEEPSSDS-------ESARPG--PWDRLSLPRTGESN------ 3423

  Fly  3194 NNGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKI 3258
                         :|...|......|       .|.:......:|:|.|:|.|:
Zfish  3424 -------------KPSTWDPANRSGL-------SDLNKYSGMLSCSDDELSPSD----------- 3457

  Fly  3259 LDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYIN 3323

Zfish  3458 ----------------------------------------------------------------- 3457

  Fly  3324 EMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPH 3388
                                    .||...:|::|                            ||
Zfish  3458 ------------------------GEEHVPLSRDQ----------------------------PH 3470

  Fly  3389 LLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYL 3453
            |.:||.|:|||:.::.||...|..|.|.||.||.|.||..|   .:..|.|.:::|:..:|:.||
Zfish  3471 LRFEIASDDGFSIEADSIEVAWSAVLEGVQEARAAAGLRLL---TMCGMSGARVMGMLHDAVVYL 3532

  Fly  3454 IEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDEL 3518
            :|||.|.::|.::|.::||:                                      .|..|:|
Zfish  3533 VEQLQGAKRCHRHTFRFHKQ--------------------------------------ASQDDDL 3559

  Fly  3519 EENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELV---PRRGTGSNLPMAMKYR 3580
            ..|...|||.|.|..:|.:|||::|||:||:.|........::|::   .||.|...|||||::|
Zfish  3560 PVNPSGCARSEVYLRKSTFDMFNFLASQHRQLPDTDLYDEEEDEVLLKSTRRATSLELPMAMRFR 3624

  Fly  3581 TLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFK 3645
            .|:.|.|:.|||:||.||||||:|.::||||||||||:|.:|||.||||||:|||.:|||||||:
Zfish  3625 HLERTSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYDGKGIGCYMFR 3689

  Fly  3646 IDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED- 3709
            |||..||||||.|||||||||.|||||||:|:::.|.|||:|||||:|.:|||||||||||.||
Zfish  3690 IDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDA 3754

  Fly  3710 -EKIPCSCGSKRCRKYLN 3726
             .|:.|:||:||||::||
Zfish  3755 SNKLGCNCGAKRCRRFLN 3772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	19/113 (17%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	18/75 (24%)
		PHD	1346..1390	CDD:214584	16/51 (31%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	29/55 (53%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	54/103 (52%)
		FYRN	1891..1935	CDD:283589	13/43 (30%)
		FYRC	3388..3476	CDD:197781	35/87 (40%)
		SET	3590..3710	CDD:214614	91/121 (75%)
kmt2bb	XP_002664717.2	termin_org_DnaJ	<455..>958	CDD:274808	90/518 (17%)
		zf-CXXC	1407..1452	CDD:251032	5/44 (11%)
		PHD1_KMT2B	1654..1700	CDD:277064	18/75 (24%)
		PHD2_KMT2B	1702..1750	CDD:277066	16/51 (31%)
		PHD3_KMT2B	1787..1843	CDD:277068	29/55 (53%)
		Bromo_ALL-1	1857..1979	CDD:99925	32/188 (17%)
		ePHD_KMT2A_like	2081..2185	CDD:277134	54/103 (52%)
		FYRN	2233..2279	CDD:283589	15/46 (33%)
		DUF1421	2770..3107	CDD:284607	96/482 (20%)
		FYRC	3470..3555	CDD:295414	35/125 (28%)
		SET	<3606..3772	CDD:225491	111/165 (67%)
		SET	3634..3754	CDD:214614	90/119 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577708
Domainoid	1	1.000	177	1.000	Domainoid score	I3544
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	752	1.000	Inparanoid score	I543
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323459at33208
OrthoFinder	1	1.000	-	-		FOG0003601
OrthoInspector	1	1.000	-	-		otm25037
orthoMCL	1	0.900	-	-		OOG6_104912
Panther	1	1.100	-	-	LDO	PTHR45838
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8862
SonicParanoid	1	1.000	-	-		X2477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790