Protein Alignment trx and LOC5667390

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_001688545.2
• Gene: LOC5667390 / 5667390
• VectorBaseID: AGAMI1_008373
• Length: 1248
• Species: Anopheles gambiae
• Alignment Length: 1461
• Identity: 279/1461 - (19%)
• Similarity: 455/1461 - (31%)
• Gaps: 547/1461 - (37%)

  Fly    29 ANPAEPQQPAPESQQPSGSGSGSSAAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGN-G 92
            |:|:....|||.....|   :..:|.:|:.............|||   |:|:|:|....|:.| |
Mosquito   161 ASPSANVGPAPGGVIQS---TTVAALKERMQGMGTSLTPGTGGGA---GSTSSNSFALTNAINDG 219

  Fly    93 SSSGSSTG-----SGSSGSGSTNGGSVNGGTHHKSAANLDKEAVTKDQ---NGDGDKTRG----- 144
            |:|.|..|     :|.:|.|:   |::|..|.::.||.:....:.||.   |.:.|...|
Mosquito   220 SNSSSVIGASMMRAGGNGFGA---GALNNRTANELAALVSGSLLVKDAKQINSEMDGKNGRDCFS 281

  Fly   145 NVSSAPSGK-----------LSAAASGKALSKSSRTFSASTSVTSSGRSSGSSPDGN--SGASSD 196
            ::.||...|           ||.:....:.::||...||:.|.|    .|.|.|..|  .|:||.
Mosquito   282 HLESADLVKEFVLQTMHCNALSVSPKRTSPARSSSVQSAALSPT----RSRSPPQLNLLLGSSSI 342

  Fly   197 GASSGISC--GKSTAKSTEASSGKLAKTTGAGTCSSAKSSKASSGTTSEATTSGLSGACLKALFV 259
            ....|:.|  |.....::.|:...||..|.| |.|:|:.....| ..:.|..|.|:|.....|.|
Mosquito   343 DGKLGVDCLTGAFPLPTSNAAVPSLALNTDA-TASAAEGPDVGS-VAARAIGSLLAGGSSHDLSV 405

  Fly   260 ATPATSTGLACALVSPGGSSQGGTFPISAALL---RARKNSNKKFKNLNLARGEVMLPSTSKLKQ 321
            .....    ||.|.:|..|..|.:...|...:   .:|.|.|        ||.......|:|:..
Mosquito   406 GASIP----ACPLANPAASPTGHSMASSEDSVDSSNSRSNGN--------ARRRRKPEKTNKMNA 458

  Fly   322 LNSPVVDNPSPSPPIASGSTPSVEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDPSPSSCTAAA 386
            ...|    |.....:..|:.||.:|        .|...|.|..:.....|...|:...:......
Mosquito   459 AAFP----PEEGKSLFHGAKPSTDG--------PPTASAMLDELDGLRSNHTGRNDITALAIEGI 511

  Fly   387 NGAASGKGSAS---NGPPAMASSG-DGSSPKSGADTGPSTSSTTAKQKKTVTFRN---VLETSDD 444
            |..:.|..:|.   :.|.:.||:. :|:.|::|:...|..:....:     .||.   :.|.|.|
Mosquito   512 NALSHGLAAAQCDLSQPTSHASAPVEGAGPRAGSGGQPHANDLPHE-----LFRKAGPLAEASPD 571

  Fly   445 -----KSVVKRFYNPDIRIPIVSIMKKDSLNRPLNYSRGGECIVRPSILSKILNKNSNIDKLNSL 504
                 :|:::...:.:..:|.|::..:|           |:.   ....:..:|....|||:.::
Mosquito   572 QQKLLESLIQSNMSANSTVPPVAVAAED-----------GKL---SGTAAAAMNDCETIDKIAAM 622

  Fly   505 KFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEG----------GVTFRRNDSPEDQNNA 559
            ...:...:|.....::|:.:.:.             |||          |......|.||
Mosquito   623 VSATTAMASKFFADKAGTENGIV-------------DEGLPATSGMHCNGPALPAKDVPE----- 669

  Fly   560 EDDEMDDDDDDEEAEEDDENEDDNDEAVSEKSAETEKSAGADERDPDEKQLVMDSHFVLPKRSTR 624
                  ...|.|...:.|:..:..|.:..|...:.|:.....|.:|:::   .||  ||...|..
Mosquito   670 ------GGGDGENVHKADKKANAADSSYEEVENKLEEMFAGIEEEPEKR---TDS--VLRAESAS 723

  Fly   625 SSRIIKPNKRLLEEGAISTKKPLSLGDSKGKNVFGTSSSSAGSTASTFSASTNLKLGKETFFNFG 689
            ||          |:...|..:|:                    ||:..||:
Mosquito   724 SS----------EDRGSSAVEPV--------------------TAAIDSAA-------------- 744

  Fly   690 TLKPNSSAAGNFVLRQPRLQFQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGSLASTNSST 754
               |..:.:.:.|::|                             .:|.||.|:
Mosquito   745 ---PAKNLSDSEVMKQ-----------------------------LSNDLAASA----------- 766

  Fly   755 VTPTPSACSICSAVVSSKEVTQARKYGVVACDVCRKFFSKMTKKSISANSSTANTSSGSQQYLQC 819
                                                          :|.::.|.|::||.
Mosquito   767 ----------------------------------------------AAAAAAAATATGSD----- 780

  Fly   820 KGNEGSPCSIHSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSAILPPGMRGEAAAR 884
                 ||....|.|..|                        .||..||       .|.:|
Mosquito   781 -----SPAGTGSGKKPL------------------------TPAQKRS-------IGSKG----- 804

  Fly   885 EEKSAELLSPTGSLRFTSTASSSSPSVVASTSVKWKSSGDSTSALTSIKPNPLAENNVTFGSTPL 949
                    .|.|.:      ::|:|:.......|.||:|         ||           |.|.
Mosquito   805 --------GPAGEM------ATSTPAAKRKRGPKKKSNG---------KP-----------SVPF 835

  Fly   950 LRPAILENPLFLKISNAADQKLAAAEAISPSLTKKNSKQEKEKV-KESEQSEKLLSPTQAGTKKS 1013
            |.|   |.|..|                  .|...||||:|.|. |:...:.|......:|.|..
Mosquito   836 LEP---EGPPML------------------GLKALNSKQKKGKPGKKGPAAGKKGKAGGSGNKGK 879

  Fly  1014 GAAEAQVEEVQPQKEE-----APQTSTTTQPSASNGASHGVPQAELAGETNATGDTLKRQRIDLK 1073
            |:.       |.:::|     ...|:.|:...|..|..:                         :
Mosquito   880 GSK-------QDERDEGGAWSGAGTNNTSSAEAGGGGKY-------------------------R 912

  Fly  1074 GPRVKHVCRSASIVLGQPLATFGEDQQPEDAADMQQEIAAPVPSAIMEPSPEKPTHI-------- 1130
            ||.|:.....:..|:..|::    ::..|......::....:.|:  |.|..:..|:
Mosquito   913 GPYVQVKSSGSHTVINAPIS----EEDGEKTQHKTKKFGNSLNSS--ERSKIRGLHVSTLSTKYD 971

  Fly  1131 --VTDENDNCASCKTSP----VGDESKP---SKSSG----------------------SAQAEVK 1164
              .||.:..|..|||.|    :||...|   |.:||                      |:||:.:
Mosquito   972 ADTTDTSWMCVFCKTGPHKFRLGDLFGPYIISTTSGEYEQSQVDVDFFSVRRTREDLESSQAKQR 1036

  Fly  1165 KATALGKE----------------GTASA-----AGGSSAKVTTRNAAVASNLIVAASKKQRNGD 1208
            :|....||                |.|:|     ||.||||             ..|.|::...|
Mosquito  1037 RAAEKLKEQQQQGGPKGKKRKNAAGAAAAVPGAPAGPSSAK-------------AMALKQEPCDD 1088

  Fly  1209 IATSSS------VTQSSNQTQGRKTKEHRQQRTLISIDFWENYDPAEVCQTGFGLIVTETVAQRA 1267
            :...|:      :.::|:.|                .:.|.:.| ..|...|..::.|..|...|
Mosquito  1089 VVDRSACEIFYGMVKASDNT----------------YEVWTHED-CLVWAPGVYMVGTRIVGLEA 1136

  Fly  1268 L--------CFLCGSTGLDPLIFC---AC-------CCEPYHQYCVQDEYNL--KH-----GSFE 1307
            .        |.||.:.|  .::.|   .|       |....|....:|..:.  :|     ||..
Mosquito  1137 AIWNCCRHQCQLCRNYG--AVLSCLHQGCHAKAHYICAHKQHWKLTEDFQSFCDRHSGHSGGSVN 1199

  Fly  1308 DTTLMGSLLET-----TVNASTGPSSSLNQL 1333
            |.:.:..:..|     .|.|:..|.::..||
Mosquito  1200 DVSKVEEVDATGGGGGAVAATVAPLATTKQL 1230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390	10/93 (11%)
		PRK13914	<1006..>1224	CDD:237555	53/288 (18%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	19/96 (20%)
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781
		SET_KMT2A_2B	3575..3726	CDD:380947
LOC5667390	XP_001688545.2	None