Protein Alignment trx and setd1a

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_021329647.2
• Gene: setd1a / 556535
• ZFINID: ZDB-GENE-080521-4
• Length: 2253
• Species: Danio rerio
• Alignment Length: 1870
• Identity: 387/1870 - (20%)
• Similarity: 642/1870 - (34%)
• Gaps: 512/1870 - (27%)

  Fly  2090 SICDEDTRNSNTSLGNGWPASNPVEDAMLS---AARNSSQVQMLKTLAWPKLDGNSAMATAIKRR 2151
            ||....|..|:|||.:..|:|.    |.||   ..|:||........:.|.:..:|::.:.|: .
Zfish   663 SIPSSSTSPSSTSLPHHLPSST----ASLSPPPPQRDSSPEPDSTNESLPFMHHSSSLDSRIE-M 722

  Fly  2152 KLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKRYF 2216
            .|.:..|:..||....:...|.|:       |.:..||.|.:|    ...:|.     ...:|..
Zfish   723 LLKEQKAKFSFLASDDEDDEKDEV-------RERGKSENSKDG----GNKLRE-----HGGERPS 771

  Fly  2217 EKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLP 2281
            .|.:|..||.:.|              |....||..|..
Zfish   772 HKRQGEMEAGQQR--------------RRGEKDGRRSRG-------------------------- 796

  Fly  2282 SCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLG 2346
                       :..|||.|                       .|.....:.|:|.|.|.||.|
Zfish   797 -----------KRQVSGVG-----------------------EGRKTPPEVASSTPTVHSLVS-- 825

  Fly  2347 QFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQ-------IYANSLQSLAANLGGGFTLA 2404
             ..|||    |:.|             |..:..|.|..       .|....|....:.|....::
Zfish   826 -ESLQG----QIPP-------------PQEEHTTSDTHRAPHTPPTYNGEAQPSPRSSGEDMEIS 872

  Fly  2405 QP---TVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTA-TYQTLQATNTDKKI-MLPLTA 2464
            ..   |:|........:.|::|..:.|.:...||...:.:|.. |.|...||.....| ..|...
Zfish   873 DEDDNTITTATSHPAASSSSSPAASSQTVLPSQTTDPSASPAPDTSQHFSATMPPPPIPSYPPHL 937

  Fly  2465 AGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQ------QHQQQQQTQVQ------- 2516
            ...||...:.:......           :.|....::.||:      .|.....:.::
Zfish   938 PPPPLPGFSLQPPPPPG-----------IPPPLPHMELHPEYPPPLPHHMYDYASSMELMSQYCG 991

  Fly  2517 -QPITVMGQNLLQP---QLLFQSSTQTQAPQIILPQA--------------------QPQNIISF 2557
             .|::...|..:..   |:...||..|.||...:|.|                    .|.:  .:
Zfish   992 GAPMSFQMQTHMLSRLHQMRMASSNSTAAPPAEVPPASEYPPSYHLHSIPPPHAPPHHPHH--PY 1054

  Fly  2558 VTGDGS----QGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPS 2618
            :..||:    ..|..:||..|....| |.|.....|...|..|.      .|....:|:....||
Zfish  1055 MDQDGNVASHYDQDHRYIPPPLPYAY-PDPHAAQLPHHHTIPPP------HTPWPPHLLPQQFPS 1112

  Fly  2619 NSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATTSP 2683
            :     .......|.|.|.|.|.         ||.|:|
Zfish  1113 H-----YPPPGFGAVPGVDGELY---------GAAGDQ--------------------------- 1136

  Fly  2684 QVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLS----QNASFSATTTQVF--QASKIEPIV 2742
            ..|:...|    .|.:||..:.:..:.:...|...|:    :|.:| .|..:.:  :..|.:|..
Zfish  1137 MAIMGHNP----CEAVVQQVLAALIEEMKNIMQRDLNRKMVENVAF-GTFDEWWDRKERKAKPFQ 1196

  Fly  2743 DLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPT-----SSGASTS 2802
            ....|..|                  |.:::.:::.||..:..:|...:.:.:     .||....
Zfish  1197 TAMRGVAV------------------VREEEKKEEKTTTTMTTSNRPREPLMSLVDWAKSGGMEG 1243

  Fly  2803 MDYTSPVMVTAKIPPVTQIKRTNAQAKAAGIS---GVGKVPPQPQVVNKVLPTSI-----VTQQS 2859
            ......:.:     |..::||...|....|..   .....||..:..:.....|.     .|::.
Zfish  1244 FSLRGALRL-----PSFKVKRKEPQELVEGDELKRARPSTPPDEEDEDSYQGKSADAAAGRTEER 1303

  Fly  2860 QVQVKNSNLKQSQVKGKA-----ASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVM--- 2916
            :|..:.:..::|:.|.:.     :.|..|:.|:    :|:...:.::.:.     |.:.:.:
Zfish  1304 RVAERGAARRRSRAKARKPYELDSEGEETSDGS----SSEKEDEDSDKVD-----ESEDEALSAD 1359

  Fly  2917 --------KPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQ 2973
                    ..:....:.:.|.....::.:.:.:|...:..::.:.:.|:... ....|::.:..:
Zfish  1360 SDDESVSSSSSESSSSSSASSSSSDEEDEEEGEQAAESESLDTMDESTMDSV-AAVDTEKDERDK 1423

  Fly  2974 AQM----IHIPQQQQ-------PLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANR 3027
            |.:    :..|:.:|       |:.......:||.||:.|   |.::.:......::|:.|:...
Zfish  1424 ASLDQPSVTTPEDKQEEEKSATPVPPSSPYPRPSSPILLL---PPLKKRRKTVSFSMEESEVKPS 1485

  Fly  3028 VQHFSTSSSSSSSNCSLPTNV---VNPMQQQAPSTTSSSTTRPTNRVLPMQQRQE---------- 3079
            ||. ||:||.|.|..|..::|   |:|:....|:..|:| ::|...:||...|..
Zfish  1486 VQS-STASSPSPSPVSQASDVPPSVSPVSTPTPAAPSAS-SKPVPMLLPFASRPSESSALTSPAS 1548

  Fly  3080 -------PAP---LSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPV-------- 3126
                   |.|   |..:.|..|...||.|...|     ...|..:......|.|:||
Zfish  1549 PSAILTVPPPVRSLRPDEPKKSPGPPPSPQTPP-----PKNSTKRGKDSPRTPPAPVCLTVQNLP 1608

  Fly  3127 YEAELKVSSVLESIVP-DVTMDAILEEQP--VTESIYTEGLYEKNSPGESKTEQLLLQQQQREQL 3188
            .:....|....|..|| ..|.......:|  :::|.....|:......:...|:|    :||.:|
Zfish  1609 LDHASMVKMAYEDPVPLPTTQKGRARGRPRTLSQSASASHLHPALEEEDEDEEEL----EQRLKL 1669

  Fly  3189 NQQLVNNGYL------------LDKHTFQVEPMDTDVYREE----DLEEE---EDEDDDFSLKMA 3234
            .:||..:..|            |.....:::| :.|:..||    |..||   |:|:.||.....
Zfish  1670 REQLGVSSLLQLASAPKPDLSVLADVALKMDP-EADIDSEETETSDEAEEHKLEEEEGDFFAPHP 1733

  Fly  3235 TSACND-------HEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASA-GYQQMVED 3291
            .....|       .|.:.|:.||.:        ::|.........:...:..|.:. |.|:..|:
Zfish  1734 RQPLLDPEGLFVMQEHNYSKTPAPQ--------HITPPQKKTKQDSTVLLPADLNQHGVQEAPEE 1790

  Fly  3292 VLATTAAQSAPTEEFEGALETA--AVEAAATYINEMADAHVLDLKQ---LQNGVELELRRRKEEQ 3351
            |:....|..|...|..|.|:..  ..|||.|....::..:    |:   :...||||.|.:.:.:
Zfish  1791 VIGEALAARAEAPELYGDLDLLCDGREAAETQTKTLSSPY----KRTGSISKEVELEERGKGKNK 1851

  Fly  3352 RTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEI---QSEDGFTYKSSSITEIWEKV 3413
            :...:::|..:   :.|:...:..| :::.||........::   |.|.|  ..|||.::..:..
Zfish  1852 KRSRKDKENEE---LQTSKKQKEKQ-VKKQKKRKLEEFEEDVDVEQLESG--ELSSSTSDSGDSD 1910

  Fly  3414 F----------EAVQVARRAH----GLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCS 3464
            |          |.|:.:.|..    ||||..:                ...|:..|.|| :.:
Zfish  1911 FGLERSLEFEKEEVRKSERLFLQEAGLTPSTQ----------------RRPKHTPESLP-IPR-- 1956

  Fly  3465 KYTPKYHKRNG--------NVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSD------- 3514
               |.|..|:.        ::..:........|..|:....|.    |.|| .|:.:|
Zfish  1957 ---PSYKNRSEFEQMTILYDIWNSGLDQEDMRLLKSTYEKLLQ----DDHG-TDWLNDTHWVPHT 2013

  Fly  3515 --------------QDELEENAYDCARCEPY--SNRSEYDMFSWLASRHRKQPIQV------FVQ 3557
                          ..:|.|:...|||.|.|  .:|.|.|::..|     .||:.:      ...
Zfish  2014 ITNIPNPRRKKKTADGQLREHVTGCARSEGYYAISRKEKDVYLEL-----DQPVTLREIGDYDTA 2073

  Fly  3558 PSDNELVPRRGTGSNL------PMAMKYRTLK----ETYKDYVGVFRSHIHGRGLYCTKDIEAGE 3612
            .|:..|..||.....|      |..|....||    :..|..:...||.||..||:..:.|.|.|
Zfish  2074 GSNRVLSERRSEQRRLLSAIGTPAVMDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADE 2138

  Fly  3613 MVIEYAGELIRSTLTDKRERYYDSRGIG-CYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKV 3676
            |||||.|:.||..:.|.||:.|...||| .|:|::|.:.::|||..||.||||||||.||||:||
Zfish  2139 MVIEYVGQSIRQMVADNREKRYAQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKV 2203

  Fly  3677 VDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3726
            :.|...|.|:|::.:.|...||:|||||||.|:.||||.||::.||..||
Zfish  2204 ITIESQKKIVIYSKQPIGVNEEITYDYKFPIEENKIPCLCGTESCRGTLN 2253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	21/112 (19%)
		SET_KMT2A_2B	3575..3726	CDD:380947	73/155 (47%)
setd1a	XP_021329647.2	None