DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and ezh2

DIOPT Version :10

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:XP_012820250.1 Gene:ezh2 / 550047 XenbaseID:XB-GENE-956215 Length:769 Species:Xenopus tropicalis


Alignment Length:934 Identity:171/934 - (18%)
Similarity:296/934 - (31%) Gaps:272/934 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  2864 KNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKL----EVKPKVMKPTPKVQN 2924
            |.|:..:..:.|:    ||......|....|.::.:...:|.:.:.    |||........|:..
 Frog     6 KPSSASRRIIMGQ----TGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFNTNRQKIME 66

  Fly  2925 QNHSLLQQQQQQQPQ-------------------------LQQQIPAVVVNQVPKVTISQQRIPA 2964
            :...|.|:.:|::.|                         .:|.||...:..|..|.|.....|.
 Frog    67 RTEILNQEWKQRRIQPVHIMTTVSSLRGTRECSVTSDLDFPKQVIPLKTLTAVASVPIMYSWSPL 131

  Fly  2965 QTQQQQLQQAQMIH-IPQQ------------QQPLQQQQVQVQPSMPIITLAEAPVVQSQ-FVME 3015
            | |...::...::| ||..            ::.::....:|.....|..:||...:..: ||..
 Frog   132 Q-QNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRGICCIAECGFINDEIFVEL 195

  Fly  3016 PQAL------EQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPST---TSSSTTRPTNRV 3071
            ..||      |..|..:..|......::...:.::......|: ::.||.   .:.|:..|....
 Frog   196 VNALAQYSDYEDDEDGDDNQDDERDDTAKDQDDNMEDQETQPL-RKFPSDKIFEAISSMFPDKGT 259

  Fly  3072 L--------PMQQRQEPAPLSNEC-PVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVY 3127
            |        .:.::|.|..|..|| |.:..|.......:..:|...:....:|:.         |
 Frog   260 LEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFK---------Y 315

  Fly  3128 EAELKVSSVLESIVPDVTMDAILEEQPVTESIY--TEGLYE----------KNSPGESKTEQLLL 3180
            :..|.......:.......:|..:.:|.....|  .||..|          |..|          
 Frog   316 DCFLHPFHATPNTYKRKNNEAANDGKPCGPHCYQLLEGAREFAAALTAERIKTPP---------- 370

  Fly  3181 QQQQREQLNQQLVNNGYLLDKHTFQV-EPMDTDVYRE---------EDLEEEEDEDDDFSLKMAT 3235
             ::...:...:|.||.......|..| |..|||..||         .|.||||.:|:..|...|.
 Frog   371 -KRPSGRRRGRLPNNTSRPSTPTVNVLEAKDTDSDREAGTETGGESNDKEEEEKKDETSSSSEAN 434

  Fly  3236 SACNDH-EMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQ 3299
            |.|... :|..:.||.                                       |:|       
 Frog   435 SRCQTPIKMKPNIEPP---------------------------------------ENV------- 453

  Fly  3300 SAPTEEFEGALETAAVEAAATYI-NEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKA 3363
                 |:.||..:.......||. |..|.|.::..|..:...|..::                ::
 Frog   454 -----EWSGAEASLFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVK----------------ES 497

  Fly  3364 AIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTP 3428
            :|:....|.:...|   |:|....|.|:..........|..|...::                  
 Frog   498 SIIAPVIAEDVDTP---PRKKKRKHRLWAAHCRKIQLKKDGSSNHVY------------------ 541

  Fly  3429 LPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSS 3493
                                                .|.|..|.|.                ...
 Frog   542 ------------------------------------NYQPCDHPRQ----------------PCD 554

  Fly  3494 ASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQP 3558
            :|....::...........|:.    :|.:...||:...|.             ::.|..:.|:.
 Frog   555 SSCPCVIAQNFCEKFCQCSSEC----QNRFPGCRCKAQCNT-------------KQCPCYLAVRE 602

  Fly  3559 SDNELVPRRGTGSNLP---MAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGE 3620
            .|.:|....|...:..   ::.|..:::...|.::.:..|.:.|.|::....::..|.:.||.||
 Frog   603 CDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGE 667

  Fly  3621 LIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHI 3685
            :|.....|:|.:.|| :.:..::|.::::.|||||.:||..||.||...||||:||:.:.|...|
 Frog   668 IISQDEADRRGKVYD-KYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRI 731

  Fly  3686 IIFALRRIVQGEELTYDYKFPFED 3709
            .|||.|.|..||||.:||::...|
 Frog   732 GIFAKRAIQTGEELFFDYRYSQAD 755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:413390
PRK13914 <1006..>1224 CDD:237555
PHD1_KMT2A_like 1268..1344 CDD:276981
PHD 1346..1390 CDD:214584
PHD3_KMT2A_like 1423..1479 CDD:276983
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1890..1937 CDD:461787
FYRC 3388..3476 CDD:197781 8/87 (9%)
SET_KMT2A_2B 3575..3726 CDD:380947 47/135 (35%)
ezh2XP_012820250.1 EZH2_WD-Binding 54..83 CDD:463308 6/28 (21%)
PRC2_HTH_1 173..272 CDD:436286 16/99 (16%)
preSET_CXC 582..613 CDD:408079 7/43 (16%)
SET_EZH2 632..751 CDD:380995 45/119 (38%)
Blue background indicates that the domain is not in the aligned region.

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