Protein Alignment trx and Set2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_061511250.1
• Gene: Set2 / 4577900
• VectorBaseID: AGAMI1_014733
• Length: 2662
• Species: Anopheles gambiae
• Alignment Length: 1923
• Identity: 337/1923 - (17%)
• Similarity: 602/1923 - (31%)
• Gaps: 647/1923 - (33%)

  Fly  2097 RNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKR---------RK 2152
            |.:.|.:..|...:...:::..|.:|:|..            .|.||..|.::.         ||
Mosquito     5 RGTGTKMSAGGRVTELADESSDSRSRSSDS------------GGRSASVTPVQEMLVASVGRGRK 57

  Fly  2153 LSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISET------SVEGVA----TTSGSVRSKSF 2207
            ..:....|.......:.|.    |:..||:....:.||      .||.:.    .||.|:.....
Mosquito    58 RGRGAGRGAGRGRGGRGRG----ASSLGVNSPPPVEETPYADGEMVEMIEILDDETSKSLEGTPG 118

  Fly  2208 TWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRN 2272
            ..|...:  ::.|..||...|....:||....:||..::..:....|....|:.
Mosquito   119 DDSVVVQ--QEEELAEEVQLMDCQTIDGKTIVVTEETLVGNEPADGTLLVDGET----------- 170

  Fly  2273 YDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATSFP 2337
                         |:...|.|.:|:..|.....::...::.|:.:
Mosquito   171 -------------TVVYIEDEPEVADSGAGTRKSKRQVKATNKFR-------------------- 202

  Fly  2338 QVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYAN--SLQSLAANLGGG 2400
                                        .|.:..|.|   .|...::.|::  |.:.:|..:|.|
Mosquito   203 ----------------------------DFVVDAPLP---MNQQPVRTYSSGKSPRRVAGTIGSG 236

  Fly  2401 FTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAA 2465
              :.||                  ||.:       .|.|:.|.|.|:|            |...|
Mosquito   237 --MLQP------------------GTSK-------QQRTSLPAAVYET------------PTKEA 262

  Fly  2466 GKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQ 2530
            ..|..|.|.:.....|      |.|.:.||:                               .|.
Mosquito   263 PPPSSTAAVRGGSTGA------KRGRKKKPV-------------------------------APS 290

  Fly  2531 LLFQSSTQTQAPQIILPQAQPQN--IISF-----VTGD-----GSQGQPLQYISIPTAGEYKPQP 2583
            :|..:........|.||:.:.:|  :||.     |.||     .|..|.|.....|..|......
Mosquito   291 ILDIAGVDPCDETIQLPRPEERNNSLISLRIDGAVFGDDDSIHSSSSQELVESGPPIMGGGTRGR 355

  Fly  2584 QPTATPTFLTTAPGAGATYL----QTDASGNLVLTTTPSNSGLQMLTAQS----------LQAQP 2634
            :|.......|....||:|::    :|.|:.|..|  .||.|....:.|..          |||..
Mosquito   356 KPKVAAVGSTPERPAGSTFIRRSYKTPANVNAAL--EPSTSVEAEVVAPEPVVDDEDVIVLQADE 418

  Fly  2635 QVIGTLIQPQTIQLGG-------------GADGNQPGSNQQPLILGGTGGGSSGLEFATTSPQVI 2686
            .:|....:..|...|.             |..|::.|...:    ||.||...|
Mosquito   419 IIIDAPEERPTSGRGSRGGRGSRGGRGSRGGRGSRGGRGSR----GGRGGRGRG----------- 468

  Fly  2687 LATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVF---------QASKIEPIV 2742
             |.:.:..|.|.:|.::|...::....:    ::|.:..||...:|.         :::.:|.||
Mosquito   469 -AARGVMEGGEEMVNDSVEGEREKEEES----VAQPSEESAEVVEVAVEHVEETVPESAMMEEIV 528

  Fly  2743 DLPAGYVVLNNTGDASSAGTFLNAASVLQQQ---TQDDTTTQILQNANFQFQSVPTSSGASTSMD 2804
            :                       ..|.|.:   |:.:...:|   |..:.:.:|....::....
Mosquito   529 E-----------------------EKVEQPEEVATEPEVQAEI---APKEEEEIPDKMDSTEQPT 567

  Fly  2805 YTSPVMVTAKIP--PVTQIKRTNAQA----KAAGISGVGK----VP---PQPQVVNKVLPTSIVT 2856
            .|.|..:..:.|  ||.:::....:.    :.|.:..:.:    :|   |..:...|..|:...|
Mosquito   568 ETEPTSMVVETPVEPVCEVETATVEVCVEEQPAPVEPIPENKPDLPEELPHDEPTQKDTPSDTAT 632

  Fly  2857 QQSQVQVKNSNL-KQSQVKGKAASGTGTTCGAPP----SIASKPLQKKTNMIRPIHKLEVKPKVM 2916
            .::..|   :|| |:.::             .||    |:.::...::.....|...:|..|:..
Mosquito   633 NKATEQ---TNLPKEPEI-------------TPPEQNASVETEKPDREDPAPPPKQIVETPPRKE 681

  Fly  2917 KPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIP---------AQTQQQQLQ 2972
            |     ::|:..|......::...:::.|....:...|...|::..|         .:.::::|:
Mosquito   682 K-----RDQDTKLTDSGGSRKGSSKERPPKESPSSRDKYRASEKSTPDEDRSRGEQRKKERKRLE 741

  Fly  2973 QAQMIHIPQQQQPLQQQ------------QVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELA 3025
            :........:.:|:..:            :|:....:.:..::.|...:.|.|  |......:..
Mosquito   742 EEMRKRTQSKDRPMGDERHEKRAVSDGAVRVKDDRKLSLDRMSSAGTERDQHV--PLGTTASDEK 804

  Fly  3026 NRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVV 3090
            ::::....:...||.     .......:::..:..||         :|...::.|
Mosquito   805 DKIRKGKEADKRSSD-----VGTAGEAKEKIATAESS---------IPSSSKKRP---------- 845

  Fly  3091 SSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPV 3155
             |..||:| ::|          .||           :|:|:|.                ||.||:
Mosquito   846 -SSIPPRP-DKP----------KKC-----------FESEMKA----------------LELQPI 871

  Fly  3156 --TESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQ----------VEP 3208
              |::.:.|......:.....:.......:.:|.......:..   .||...          ...
Mosquito   872 SRTKAPHDESRRRAETKDRDDSSSSSSSHRTKEHSRHSSSSGS---SKHKSSKSSSSHEGATARR 933

  Fly  3209 MDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKIS---KILDNLTNDD---- 3266
            :||..:|....:|:|:|...          .|......:||..:..:|   ..|...||.|
Mosquito   934 LDTSGHRSSRPKEKEEEKQQ----------RDRGEGGEKEPTGRKSVSAGGSFLQEETNRDRSIV 988

  Fly  3267 -----CADSIATATTMEVDASAGYQQMVEDVLATTAAQ--------------------SAPTEEF 3306
                 ..||...::..:....|..::..|..|.|.:.|                    ..|.|.|
Mosquito   989 KKSSKTKDSKRDSSKAKSGVEAVEEKPAEKPLVTESPQKKIEEQPVETRNVPECPPVEQEPAEPF 1053

  Fly  3307 EGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELR---------------RRKEEQRTVSQ 3356
            :.:.|...:...|:          |.:.:::..||.||.               ..|.|:..||
Mosquito  1054 KASPEAPRIVTKAS----------LKMYKMEECVEAELPTPPPPPQQPPETLQVTPKAEEIHVS- 1107

  Fly  3357 EQEQSKAAIVPT--AAAPEPPQ-----PIQEPKKMTGPHLLYEIQSEDGF----TYKSSSITEIW 3410
            |..|:|.|.:||  ....|||.     |..|||..|  ..|.|::.|:.|    |.:|.|:..:.
Mosquito  1108 EVVQTKVAELPTQLPVKEEPPATLDAVPPMEPKPET--QQLAELKEEEAFSDAETLRSDSVAGLS 1170

  Fly  3411 EKVFEAVQVARRA-------------------HGLTPLPEGPLADMGG----------------- 3439
            :.  |.:....|.                   :.|....|...|..||
Mosquito  1171 DS--EGLSAPSRCSSGFPSEDDSGVRSGASTPYDLMSCDEPDPASSGGGGSVTVVPPSSVPSVEE 1233

  Fly  3440 ----------IQMIGL-----------KTNALKYLIEQLPGVEKCSKY-----TPKYHKRNGNVS 3478
                      :.|:.|           ::..:|.:..|   .::.|.:     ..|..|::....
Mosquito  1234 VRDEDRDSQRVDMVRLVESYIDDGVIRRSTRIKTISSQ---KQRTSGHGLVRDRDKLMKKSSGAV 1295

  Fly  3479 TAANGAHGGNLGGSSASAALSVSGGDSHGLL-----------------------DYGSDQDE--- 3517
            ..|.|......||.|||.....|||...|..                       :|..|.:|
Mosquito  1296 GDAYGTAEALAGGYSASEMAMQSGGHLQGAAGVSGPAWPVIANEGDSANVELSEEYLRDMEEKLS 1360

  Fly  3518 ----LEENAYDCARCEPYSNRSEYDMFSWLASRH-RKQPIQVFVQPSDNELVPRRG--------- 3568
                :.||.|       :|:|        :.||. :|.....|:...:.|    ||
Mosquito  1361 RFETIRENIY-------HSDR--------IVSREAKKMTCDCFLTHEEIE----RGEHGCGEDCL 1406

  Fly  3569 -------TGSNLPMAMKYRTLKETYKDYV--GVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRS 3624
                   .||...:..:....:...::|.  .|||:...|.|:..:..|..||.::||.||::.|
Mosquito  1407 NRLLMIECGSRCTVGDRCTNRRFQRQEYAHCQVFRTEKKGFGIQASSAIAPGEFIMEYVGEVLNS 1471

  Fly  3625 TLTDKR-ERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIF 3688
            ...|:| |.|...:....|...:..:.::|||.:||.:|||||.|:||..::...:.|...|..|
Mosquito  1472 AQFDERAEAYSREKNKHYYFMALRSDGIIDATTKGNISRFINHSCDPNAETQKWTVNGELRIGFF 1536

  Fly  3689 ALRRIVQGEELTYDYKFPFEDEKI-PCSCGSKRCRKYL 3725
            :.:.|:.|||:|:||:|.....|. .|.|.::.||.::
Mosquito  1537 STKYILPGEEITFDYQFQRYGRKAQKCYCEAESCRGWI 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	21/153 (14%)
		SET_KMT2A_2B	3575..3726	CDD:380947	48/155 (31%)
Set2	XP_061511250.1	None