DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trx and pie

DIOPT Version :9

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001260348.1 Gene:pie / 44315 FlyBaseID:FBgn0005683 Length:582 Species:Drosophila melanogaster


Alignment Length:469 Identity:83/469 - (17%)
Similarity:151/469 - (32%) Gaps:130/469 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1269 CFLCGSTGLDPLIFCACCCE---PYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSL 1330
            |.:|..:..|.|:|......   ..|.:|:....:|.....:.:.::|.||......:.....  
  Fly     9 CLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEK-- 71

  Fly  1331 NQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRPLICVNCLKCKS 1395
                          ..|:.|| ..|:.::|.:|:..:|..|        |.:...:...|.:.||
  Fly    72 --------------RKCWYCN-KIGASLQCDRCRSLFHLKC--------GLENRAVFEFCGQYKS 113

  Fly  1396 CSTTKVSKFVGNLPMCTGCFKLRKKGNF-------------CPIC-QRCYDDNDFDLKMMECGDC 1446
            .                 |:|.|...::             |||| ...|   ..:|..:..|||
  Fly   114 Y-----------------CYKCRPMDDYKRQLQSNPPRNATCPICFSSIY---KVELHCVVYGDC 158

  Fly  1447 GQ--WVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKA----------EEWRQAVME 1499
            .:  :.|.||.    .||.|.|..  .:..|..:..|..:|.::::          |:.|.|..|
  Fly   159 CRLGFAHKKCM----RQYALTSGY--YLRCIWCRSERFRDSIRLQSVFVPDRDATWEKQRNAYRE 217

  Fly  1500 EFKASL--------------YSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQF 1550
            ..:.:|              |:.|..:.....:||    :....|:|..||.....|.:....:.
  Fly   218 LHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCA----ATSAHLKCLVGALRLPKKRERTDFKC 278

  Fly  1551 S---------------------SGSDN---------GLGSDGESQNSDDVYEFKDQQQQQQQRNA 1585
            |                     :..||         .||.|..:::......|.::.:.::..|.
  Fly   279 SMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSLTQTPVFSEEDESERSSNI 343

  Fly  1586 NMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDE-LDIAY 1649
            .:...:.||...|.:..:|..|...:|:|......:...|:.| |:....:.::...|. ..||.
  Fly   344 TVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDE-NHSPQPIARRDTSDSPQPIAA 407

  Fly  1650 KELLSEQFPWFQNE 1663
            .|:.....|...:|
  Fly   408 SEIPDSPQPTAASE 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:295381
PHD1_KMT2A_like 1268..1344 CDD:276981 11/77 (14%)
PHD 1346..1390 CDD:214584 9/43 (21%)
PHD3_KMT2A_like 1423..1479 CDD:276983 17/71 (24%)
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1891..1935 CDD:283589
FYRC 3388..3476 CDD:197781
SET 3590..3710 CDD:214614
pieNP_001260348.1 PHD_SF 9..117 CDD:304600 24/149 (16%)
PHD_SF 224..>260 CDD:304600 5/39 (13%)
PARM 318..>491 CDD:293666 19/105 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1084
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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