DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and KMT2A

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	XP_011541131.1	Gene:	KMT2A / 4297	HGNCID:	7132	Length:	4005	Species:	Homo sapiens

Alignment Length:	4597	Identity:	1031/4597 - (22%)
Similarity:	1631/4597 - (35%)	Gaps:	1470/4597 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSKFPGKPSKS-------------INRKRISVLQLED----DAANPAEPQQPAPESQQPSGSGSG 50
            |.:||.:|..:             ..|:|:..|.|..    ....|..|  |:|.:...:.:.:|
Human     6 RWRFPARPGTTGGGGGGGRRGLGGAPRQRVPALLLPPGPPVGGGGPGAP--PSPPAVAAAAAAAG 68

  Fly    51 SSAAREKGNNCDNDEDDNAPGGASISGNTASSSAGSGNSGNGSSSGSSTGSGSSGSGSTNGGSVN 115
            ||.|             ..||||:.:...:||||        |||.||:.|.|||......|...
Human    69 SSGA-------------GVPGGAAAASAASSSSA--------SSSSSSSSSASSGPALLRVGPGF 112

  Fly   116 GGTHHKSAA---NLDK-EAVTKDQNGDGD------------KTRGNVSSAPSGKLSAAASGKALS 164
            ......|||   ||.: .||..:..|.|.            :|:|::....:......|....|:
Human   113 DAALQVSAAIGTNLRRFRAVFGESGGGGGSGELTTQIPCSWRTKGHIHDKKTEPFRLLAWSWCLN 177

  Fly   165 KSS------------RTFSASTSVTSSGRSSGSSP----DGNSGASSDGA----------SSGIS 203
            ...            |:.:.|.||.:|.|.....|    |.||...||.:          .||..
Human   178 DEQFLGFGSDEEVRVRSPTRSPSVKTSPRKPRGRPRSGSDRNSAILSDPSVFSPLNKSETKSGDK 242

  Fly   204 CGKSTAKSTEASSG--------KLAKTTGAGTCSSAKSSKASSGTTSEATTSGLSGACLKALFVA 260
            ..|..:||.|...|        |:..|.|.......|.:|..|               ||.: ..
Human   243 IKKKDSKSIEKKRGRPPTFPGVKIKITHGKDISELPKGNKEDS---------------LKKI-KR 291

  Fly   261 TPATSTGLACALVSPGGSSQGGTFPISAAL--LRARKNS--NKKFK--NLNLARGEVML------ 313
            ||:                  .||..:..:  |||.|.|  ..|||  .|.:.|..|.:
Human   292 TPS------------------ATFQQATKIKKLRAGKLSPLKSKFKTGKLQIGRKGVQIVRRRGR 338

  Fly   314 -PSTSKLKQLNSPVVDNPSPSPPIASGSTPSVEGGIGVGGVVSPGEDAALKRVLTEMPNEVARDP 377
             |||.::|                    |||        |::...|        .|.|.:|.:|.
Human   339 PPSTERIK--------------------TPS--------GLLINSE--------LEKPQKVRKDK 367

  Fly   378 SPSSCTAAANGAASGKGSASNGPP-------AMASSGDGSSPKSGADTGPSTSSTTAK------- 428
            ..:                   ||       .:..|.....|.....:...|.:|.||
Human   368 EGT-------------------PPLTKEDKTVVRQSPRRIKPVRIIPSSKRTDATIAKQLLQRAK 413

  Fly   429 ---QKKTVTFRNVLETSDDKSVVKRFYNPDIR---IPIVSIMKKDSLNRPLNYSRGGECIVRPSI 487
               |||.......|:....|:.||     :||   :|:||.:....:..|..:....:  ..|.|
Human   414 KGAQKKIEKEAAQLQGRKVKTQVK-----NIRQFIMPVVSAISSRIIKTPRRFIEDED--YDPPI 471

  Fly   488 LSKILNKNSNIDKLNSLKFRSAGASSSSSNQESGSSSNVFGLSRAFGAPMDEDDEGGVTFRRNDS 552
                     .|.:|.|.......|.|..|:::|.::|.       ..:.|..|..      |:.|
Human   472 ---------KIARLESTPNSRFSAPSCGSSEKSSAASQ-------HSSQMSSDSS------RSSS 514

  Fly   553 PE-----DQNNAEDDEMDDDDDDEEAE--------EDDENEDDNDE-----AVSEKS--AETEKS 597
            |.     |...:|:.::..::..:..|        :..||| .||.     :|||:|  :.|.|.
Human   515 PSVDTSTDSQASEEIQVLPEERSDTPEVHPPLPISQSPENE-SNDRRSRRYSVSERSFGSRTTKK 578

  Fly   598 AGADERDPDEK--------------------------------QLVMDSHFV----LPKRSTRSS 626
            ....:..|.::                                .:.:.|.|:    .|.:..|.|
Human   579 LSTLQSAPQQQTSSSPPPPLLTPPPPLQPASSISDHTPWLMPPTIPLASPFLPASTAPMQGKRKS 643

  Fly   627 RIIKP------------------NKRLLEEGAISTKKPL------------SLGDSKGKNVFGTS 661
            .:.:|                  :.:..:||.|  :||:            .:|.:.|.:..||:
Human   644 ILREPTFRWTSLKHSRSEPQYFSSAKYAKEGLI--RKPIFDNFRPPPLTPEDVGFASGFSASGTA 706

  Fly   662 SSS-------AGSTASTFSASTNLKLGKET-------FFNFGTLKPNSSAAG---NFVLRQPRLQ 709
            :|:       :|:.......|..|:..:.|       .|...||..|.::||   :.|..:.|
Human   707 ASARLFSPLHSGTRFDMHKRSPLLRAPRFTPSEAHSRIFESVTLPSNRTSAGTSSSGVSNRKR-- 769

  Fly   710 FQADNQQATFTAPKACPTSPSAIPKPANSLATSSFGSLASTNSSTVTPTPSACSICSAVVS---- 770
                 ::..|:..::.|.|||      :|:.|.| |.|:|:..|.:||..|..|..|..||
Human   770 -----KRKVFSPIRSEPRSPS------HSMRTRS-GRLSSSELSPLTPPSSVSSSLSISVSPLAT 822

  Fly   771 ----------SKEVTQ----ARKYGVVACDVCRKFFSKMTKKSISANSSTANTSS---------- 811
                      |..:||    |.|             ::..:|..||.:...::||
Human   823 SALNPTFTFPSHSLTQSGESAEK-------------NQRPRKQTSAPAEPFSSSSPTPLFPWFTP 874

  Fly   812 GSQQYLQCKGNEGSPCSI---HSAKSQLKNFKKFYKDRCTACWLKKCMISFQLPAAHRSRLSAIL 873
            |||.. :.:..:.:|..:   ..|...::..|...:||                  .|.:
Human   875 GSQTE-RGRNKDKAPEELSKDRDADKSVEKDKSRERDR------------------EREK----- 915

  Fly   874 PPGMRGEAAAREEK--------SAELLSPTGSL---RFTSTASSSSPSVVASTSVKWKSSGDSTS 927
                ..:..:|:||        |:..|.|.|.:   :......::|.|...:|..|..||.||.:
Human   916 ----ENKRESRKEKRKKGSEIQSSSALYPVGRVSKEKVVGEDVATSSSAKKATGRKKSSSHDSGT 976

  Fly   928 ALTSIKPNPLAENNVTFGSTPLLRPAILENPLFLKISNAADQKLAAAEAISPSLTKKN----SKQ 988
            .:||          ||.|.|..::..|    |..|.....::........:|||.|:.    |..
Human   977 DITS----------VTLGDTTAVKTKI----LIKKGRGNLEKTNLDLGPTAPSLEKEKTLCLSTP 1027

  Fly   989 EKEKVKES--------EQSEKLLSPTQAGTKKSGAAEAQVEEVQPQKEEAPQTSTTTQPSASNGA 1045
            ....||.|        .|::||....:........|:||:.::    |::.....|.||.|.
Human  1028 SSSTVKHSTSSIGSMLAQADKLPMTDKRVASLLKKAKAQLCKI----EKSKSLKQTDQPKAQ--- 1085

  Fly  1046 SHGVPQAELAGETNATGDTLKRQRIDLKGPRVKHVCRSASIVLGQPLATFGEDQQ---------- 1100
                      |:.:.:.:|      .::|||:|||||.|::.||:..|.|.:|..
Human  1086 ----------GQESDSSET------SVRGPRIKHVCRRAAVALGRKRAVFPDDMPTLSALPWEER 1134

  Fly  1101 -----------------PEDAADMQQEIAAPVP--------SAIMEPSPEK----------PTHI 1130
                             .|||    :.:|.|:.        .|..||..:|          |...
Human  1135 EKILSSMGNDDKSSIAGSEDA----EPLAPPIKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQ 1195

  Fly  1131 VTDENDNCASCKTSP-------------------------------------------------- 1145
            |.::...|.:|...|
Human  1196 VPEDCGVCTNCLDKPKFGGRNIKKQCCKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKD 1260

  Fly  1146 ----------VGDESKPS---------KSSGSAQAEVKKATALGKEGTASAAGGSSAKVTTRNAA 1191
                      |....||:         |.|.|.....|......:||..||.|..|.:.||..:.
Human  1261 SKESSVVKNVVDSSQKPTPSAREDPAPKKSSSEPPPRKPVEEKSEEGNVSAPGPESKQATTPASR 1325

  Fly  1192 VASN------LIV--------------------AASKKQ-----------RNGDIATSSSVTQS- 1218
            .:|.      |::                    ...|||           :...:|...|:...
Human  1326 KSSKQVSQPALVIPPQPPTTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQ 1390

  Fly  1219 -----------------------SNQTQGRKTKE-------HRQQRTLISIDFWENYDPAEVCQT 1253
                                   |..:.|..:|:       ||     |.:||.|:.:...|.:.
Human  1391 KPKEKEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHR-----IRVDFKEDCEAENVWEM 1450

  Fly  1254 -GFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLE 1317
             |.|::.:..:..|.:||||.|:|....::|..||||:|::|:::    .....||
Human  1451 GGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEE----NERPLED--------- 1502

  Fly  1318 TTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTC---NMSSGSKVKCQKCQKNYHSTCLG------ 1373
                             |..||.|.||..|:.|   :.::...::|.||:.:||..|||
Human  1503 -----------------QLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTK 1550

  Fly  1374 -TSKRLLGADRPLICVNCLKCKSCSTTKVSK-----FVGNLPMCTGCFKLRKKGNFCPICQRCYD 1432
             |.|:     :..||..|::||||.:|...|     :..:..:|..|.||..||||||:|.:|||
Human  1551 PTKKK-----KVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYD 1610

  Fly  1433 DNDFDLKMMECGDCGQWVHSKCEGLS---DEQYNLLSTLPESIEFICKKCARRNESSKIKAEEWR 1494
            |:|::.|||:||.|.:|||||||.||   ||.|.:||.||||:.:.|..|..|:.:      |||
Human  1611 DDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPESVAYTCVNCTERHPA------EWR 1669

  Fly  1495 QAVMEEFKASLYSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQFSSGSDNGLG 1559
            .|:.:|.:.||..||..|..||....||:.....|          ...|.|:       ::..:.
Human  1670 LALEKELQISLKQVLTALLNSRTTSHLLRYRQAAK----------PPDLNPE-------TEESIP 1717

  Fly  1560 SDGESQNSDDVYEFKDQQQQQQQRNANMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYV 1624
            |....:..|.....:..:|..|                         |...|..:|:|:...:|.
Human  1718 SRSSPEGPDPPVLTEVSKQDDQ-------------------------QPLDLEGVKRKMDQGNYT 1757

  Fly  1625 SLAEFNYDMSQVIQ--------QSNCDELDIAYKELLSEQ----FPWFQ---------NETKACT 1668
            |:.||:.|:.::||        |....:.:...|.....|    ||||.         |:..:.:
Human  1758 SVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNS 1822

  Fly  1669 DALEEDMFESCSGGNYEDLQDTGGVSASVYNEH-------------------------------- 1701
            ..|...:.......||...|:      ...|.|
Human  1823 GMLPNAVLPPSLDHNYAQWQE------REENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPT 1881

  Fly  1702 ----STSQAESRSGVLDIPLEEVDDFGSCGIKMRLDTRMCLFCRKSGEGLSGEEARLLYCGHDCW 1762
                ||.::...|..|:.|         .||:   |.|.|..|...|:..:.:..||||.|.:.|
Human  1882 PPILSTDRSREDSPELNPP---------PGIE---DNRQCALCLTYGDDSANDAGRLLYIGQNEW 1934

  Fly  1763 VHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSID 1827
            .|.|||:|||||||:.||||:|||.||.||:.::|..|...||||||.:.||..:||:.|:|:.:
Human  1935 THVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKN 1999

  Fly  1828 CAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVE---LDRKRKKL--IEPARVQF 1887
            |.||.||.:||..|.   :.:|....|    |:.|||.|.|:|:   :..:||.|  :||..:..
Human  2000 CVFLDDKKVYCQRHR---DLIKGEVVP----ENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHM 2057

  Fly  1888 HIGSLEVRQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEPWKIVEYTVRTTIQNSSSTLTALDV 1952
            .|||:.:..|| |:...||..:.:.||.:.|||:|||:.:..|...||.:  |......:...|:
Human  2058 MIGSMTIDCLG-ILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCK--IVECRPPVVEPDI 2119

  Fly  1953 GRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLENGGTDWSGEFPNPNSCVPPDENT----- 2012
              |.||:|....:         ||...||...|...|:..|......|:|:.  ||...|
Human  2120 --NSTVEHDENRT---------IAHSPTSFTESSSKESQNTAEIISPPSPDR--PPHSQTSGSCY 2171

  Fly  2013 ----EEEPQQQADLLPPELKDAIFEDLP---------HELLD-GISMLDIFLYDDKTDLFAISEQ 2063
                .:.|:.:.....|..:......||         ||::. |..:|...|....:...:.|..
Human  2172 YHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSL 2236

  Fly  2064 SKDGTQ-----AMTSNQAQNQNQQAGGANSVSICDEDTR-----------NSNTSLGNGWPASNP 2112
            |...::     .|.:....::|..:..:.:.:..|.::.           ||:||||.....|:.
Human  2237 SPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSN 2301

  Fly  2113 VEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNK-KEMA 2176
            ::..:::....:|.           |||:|:       .::.::.|..:....||.:..| |.::
Human  2302 LQRTVVTVGNKNSH-----------LDGSSS-------SEMKQSSASDLVSKSSSLKGEKTKVLS 2348

  Fly  2177 TVAGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKRYFEKSE---GREEAAKMRIMQMDGVDD 2238
            :.:......:::...:..:|....:..|:....|....:.|.|.   ..:||.....:.:.|
Human  2349 SKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRG--- 2410

  Fly  2239 SITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSG---QG 2300
                                  .:.||.|           |..|.....||.:.:::|..   .|
Human  2411 ----------------------QRNDRDQ-----------HTDSTQSANSSPDEDTEVKTLKLSG 2442

  Fly  2301 MTNNATQIS----AESLNELQKQLLANAGGLNYLQSATSF--PQVQSLGSLGQFGLQGLQQLQLQ 2359
            |:|.::.|:    :.|.:..||...:.........|:.||  |...:.|..|....:.:.:: |.
Human  2443 MSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEV-LT 2506

  Fly  2360 PQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPD 2424
            |:.:|.       .|....::|.:               |...|:.|.|  |..|.:     ..:
Human  2507 PEYMGQ-------RPCNNVSSDKI---------------GDKGLSMPGV--PKAPPM-----QVE 2542

  Fly  2425 GTQQFIQIP--QTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQL 2487
            |:.:.:|.|  :|::.|.||.......|:.|..|:     ::...||                |:
Human  2543 GSAKELQAPRKRTVKVTLTPLKMENESQSKNALKE-----SSPASPL----------------QI 2586

  Fly  2488 KSGHQVKPIQAK--------LQPHPQQHQ-QQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQ 2543
            :|....:||.|.        .||.|.... |..|:...|.:.|..:||:.|          ..|
Human  2587 ESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLP----------DGP- 2640

  Fly  2544 IILPQAQPQNIISFVTGDGS----------QGQPLQYISI-PTAG--EYKPQPQPTATPTFLTTA 2595
                  :||.       |||          :.:...:..: |..|  .|..:..|     |.:::
Human  2641 ------KPQE-------DGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIP-----FYSSS 2687

  Fly  2596 PGA------------GATYLQTDASGNL----VLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQ 2644
            .|.            ||..|.|....:|    ...|..|:.|.:.|.:.:|..:.:....   |:
Human  2688 TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDL---PK 2749

  Fly  2645 TIQLGGGADGNQPG---------SNQQPLILGGTGG---------GSSGLEFATTSPQVILATQP 2691
            ..||.|..||.:..         |:|.|...|...|         ..:|.:...|...|....:|
Human  2750 ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEP 2814

  Fly  2692 MYYGLETI------------VQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEPIVD- 2743
            ......::            .|.:.:.|.:.|.|:.|   |.........|::.::.......|
Human  2815 KMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTP---SDKNLLDTYNTELLKSDSDNNNSDD 2876

  Fly  2744 ----LPAGYV--VLNNT------GDA--SSAGTFLNAA----------------SVLQQQTQD-- 2776
                ||:..:  ||.||      |::  ||:...||..                .|..||...
Human  2877 CGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTE 2941

  Fly  2777 --DTTTQILQNANFQFQ---SVPTSSGASTSMDYTSPVMVTAKIPPVTQI--KRTNAQAKAAGIS 2834
              |::.....:|..||:   .:|:.....|:...|.|....:::..::..  ||.....|:...|
Human  2942 PVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASS 3006

  Fly  2835 ---------GVGKVP-------------------------------------------PQPQVVN 2847
                     ||...|                                           |..||
Human  3007 ESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQV-- 3069

  Fly  2848 KVLPTSIVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMI----RPIHK 2908
            .|.||..:..|..|.....:...||:...|...|      ||.:  ||..:|..::    :|::.
Human  3070 PVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTT------PPHL--KPATEKLIVVNQNMQPLYV 3126

  Fly  2909 LEVKP-----KV-----MKPTPKVQNQNHSLLQQQ----------QQQQPQLQQQIPAVVVNQVP 2953
            |:..|     |:     :..||.|...|.|:|...          ....|..|...|:.....:|
Human  3127 LQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLP 3191

  Fly  2954 KVTISQQR----IPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSM-PIITLAEAP--VVQSQ 3011
               :|..:    .||.||..        ..|....|.....:.|||.. |.:.::|:.  ...|.
Human  3192 ---MSHHQHLHSFPAATQSS--------FPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLST 3245

  Fly  3012 FVMEPQALEQQELANRVQ---HFSTSSSSSSSNCSLPTNVVNPM------QQQAPSTTS----SS 3063
            .|..|.:..::...:|:|   :...:.||:.||.: |::||:.|      ..|.|:..|    .|
Human  3246 TVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIA-PSDVVSNMTLINFTPSQLPNHPSLLDLGS 3309

  Fly  3064 TTRPTNRVLPMQQRQ--------EPAPLSNEC--PVVSSPTPPKPVEQPIIHQMTSASVSKCYAQ 3118
            ....::|.:|...::        |||||..:.  ...::......:.|...| :||.|||...:.
Human  3310 LNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSH-LTSGSVSGLASS 3373

  Fly  3119 KS-----------------------TLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVT---- 3156
            .|                       ||.:|.......:.|:...::........:::|||.
Human  3374 SSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPS 3438

  Fly  3157 ---------------------------ESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVN 3194
                                       .|..|.|:...:..||:.      :..|.:.:||.|.:
Human  3439 SGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEAD------EHYQLQHVNQLLAS 3497

  Fly  3195 NGYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSL---KMATSACNDHEMSDSEEPAVKDKIS 3256
            ...:   |:.|.:.......:..:..:..|..:...|   |..:||......|....|:......
Human  3498 KTGI---HSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQ 3559

  Fly  3257 KILDNLTNDDCADSIATAT---------TMEVDASAGYQQMV--------------EDVLATTAA 3298
            :        ..:.|:...|         .:.:|...|.:..|              ::..:.|:.
Human  3560 R--------SASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSG 3616

  Fly  3299 QSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQ-SK 3362
            ...|..|.| ..:||:||.::..........|..|.::|........:...|.:||.:|:.. |.
Human  3617 TGTPGAEAE-QQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSS 3680

  Fly  3363 AAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLT 3427
            ..::......:..:.|.|.|...|  |::||.|:|||...:.||.:.|:.:.:.||.||....|.
Human  3681 PLMLWLQQEQKRKESITEKKPKKG--LVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLK 3743

  Fly  3428 PLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGS 3492
            .|   ..|.:.|::|:|:..:|:.:|||||.|.:.|..|..::||
Human  3744 QL---SFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHK-------------------- 3785

  Fly  3493 SASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPIQVFVQ 3557
                               ..:.:|...|.:..||.|.:..:|.:|||::|||:||:.|   ...
Human  3786 -------------------PEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPP---EYN 3828

  Fly  3558 PSDNE------LVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIE 3616
            |:|.|      ...||.|..:|||.|::|.||:|.|:.|||:||.||||||:|.::|:|||||||
Human  3829 PNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIE 3893

  Fly  3617 YAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILG 3681
            |||.:|||..|||||:||||:|||||||:|||:.||||||.|||||||||.|||||||:|::|.|
Human  3894 YAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDG 3958

  Fly  3682 HKHIIIFALRRIVQGEELTYDYKFPFED--EKIPCSCGSKRCRKYLN 3726
            .|||:|||:|:|.:|||||||||||.||  .|:||:||:|:|||:||
Human  3959 QKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 4005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381	22/124 (18%)
		PHD1_KMT2A_like	1268..1344	CDD:276981	19/75 (25%)
		PHD	1346..1390	CDD:214584	14/53 (26%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	34/58 (59%)
		ePHD_KMT2A_like	1737..1841	CDD:277134	52/103 (50%)
		FYRN	1891..1935	CDD:283589	15/43 (35%)
		FYRC	3388..3476	CDD:197781	31/87 (36%)
		SET	3590..3710	CDD:214614	91/121 (75%)
KMT2A	XP_011541131.1	zf-CXXC	1180..1227	CDD:251032	6/46 (13%)
		PHD1_KMT2A	1466..1512	CDD:277063	19/75 (25%)
		PHD2_KMT2A	1514..1563	CDD:277065	14/53 (26%)
		PHD3_KMT2A	1601..1660	CDD:277067	34/58 (59%)
		Bromo_ALL-1	1683..1813	CDD:99925	32/171 (19%)
		ePHD_KMT2A	1907..2019	CDD:277163	54/114 (47%)
		FYRN	2061..2107	CDD:283589	17/48 (35%)
		FYRC	3705..3788	CDD:197781	31/124 (25%)
		SET	<3861..4005	CDD:225491	102/143 (71%)
		SET	3867..3987	CDD:214614	90/119 (76%)
		PostSET	3989..4005	CDD:214703	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3624
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	708	1.000	Inparanoid score	I655
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47783
OrthoDB	1	1.010	-	-		D323459at33208
OrthoFinder	1	1.000	-	-		FOG0003601
OrthoInspector	1	1.000	-	-		otm41485
orthoMCL	1	0.900	-	-		OOG6_104912
Panther	1	1.100	-	-	O	PTHR45838
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840