DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and PR-Set7

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001247100.1	Gene:	PR-Set7 / 41743	FlyBaseID:	FBgn0011474	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	176/936 - (18%)
Similarity:	283/936 - (30%)	Gaps:	348/936 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2854 IVTQQSQVQVKNSNLKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPK---V 2915
            |:.::.|...|.:   .|...|.|:||:|.     |...:.||....|::...:....|.|   :
  Fly     2 IMVRRRQRPAKEA---ASSSSGGASSGSGI-----PVDQALPLNVAGNLLEDQYFASPKRKDCRL 58

  Fly  2916 MKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQR---------IPAQTQQQQL 2971
            ||.|...|....:::...:..:        |.....||..|.||.|         ..|:..|:.:
  Fly    59 MKVTQNGQLPEATMMAHNKDNK--------AGRTIGVPLATRSQTRTIENFFKANAAAKDSQKTI 115

  Fly  2972 QQAQMIHIPQQQQPLQQQQV--QVQPSMPIITLAEAPVVQS-QFVME-----PQALEQQELANRV 3028
            ...:.:::..|:..|..:::  |::....::.||:..:.:: .|..|     .|.|..:||...|
  Fly   116 HTEEQLNLGNQELKLDDEELNGQIKLDDEVLKLADKQINENLPFADEVDAKAEQKLMDEELQQVV 180

  Fly  3029 QH-FSTSSSSSSSNCSLPTNVVNPMQ--QQAPSTTSSSTTRPTNRVLPMQQRQEPAPLSNECPVV 3090
            :. ....||.:|||.....:.::.||  ||.|                            |.|.:
  Fly   181 EELLFDGSSRASSNSPFYQHDMDVMQEIQQTP----------------------------EIPHI 217

  Fly  3091 SSPTPPKPVEQPI------------------IHQMT-SASVSKCYAQKSTLPSPVYEAELKVSSV 3136
                  |.|.:|:                  .|..| |:|....:.|:..|...:.....|.||:
  Fly   218 ------KKVTEPLEGLGSLADFQTHRSALRDSHSSTHSSSTDNIFLQEPVLTLDIDRTPTKASSI 276

  Fly  3137 LESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDK 3201
                             .:..|....|....:.|.       :|......:.||.:..||
  Fly   277 -----------------KINRSFELAGAVFSSPPS-------VLNACLNGRFNQIVSLNG----- 312

  Fly  3202 HTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISK------ILD 3260
               |.|.:|...:   ||::.:....|..:....:|       ::|.||.:.:..|      ||
  Fly   313 ---QKEALDLPHF---DLDQHDSSSCDSGVACGLTA-------NTESPAGQPRRRKPATPHRIL- 363

  Fly  3261 NLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAA------- 3318
                  |...|.||  ::|..........:.:....:.:..||       .||||.|.
  Fly   364 ------CPSPIKTA--LKVTGGICKVGSADPLSPRKSPRKLPT-------TTAAVAACKSRRRLN 413

  Fly  3319 -----ATYINEMADAHVLDLKQLQNGVELELRRRKEEQ----------RTVSQEQEQSKAAIVPT 3368
                 |.|..::........:|.|:.:.:.|....:|.          :...:.:.|:||   |.
  Fly   414 QPKPQAPYQPQLQKPPSQQQQQQQDDIVVVLDDDDDEGDDEDDVRALIKAAEERENQNKA---PA 475

  Fly  3369 AAAPE--------PPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHG 3425
            .|...        .|.|::...|..||                                   ..|
  Fly   476 TANSNKAGMKTMLKPAPVKSKTKSKGP-----------------------------------TKG 505

  Fly  3426 LTPLPEGPLADMGGIQMIGLKTNALKYLIEQLP---GVEKCSKYTPKYHKRNGNVSTAANGAHGG 3487
            ..||   |||          .||..:.:.:..|   .|.|......:...|
  Fly   506 QPPL---PLA----------ATNGNREMTDFFPVRRSVRKTKTAVKEEWMR-------------- 543

  Fly  3488 NLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQPI 3552
                                    |.:|..|||      ||:            .|..||
  Fly   544 ------------------------GLEQAVLEE------RCD------------GLQVRH----- 561

  Fly  3553 QVFVQPSDNELVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEY 3617
                                                ::|      .|||:...:..:..|.|:||
  Fly   562 ------------------------------------FMG------KGRGVVADRPFKRNEFVVEY 584

  Fly  3618 AGELIR-STLTDKRERYYDSRGIGCYMFKI---DDNLVVDATM-RGNAARFINHCCEPNCYSKVV 3677
            .|:||. ....::.:||......||||:..   .....:|||: .|...|.|||....|..:|||
  Fly   585 VGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCIDATVDTGKLGRLINHSRAGNLMTKVV 649

  Fly  3678 DILGHKHIIIFALRRIVQGEELTYDY 3703
            .|....|:::.|...|..||||||||
  Fly   650 LIKQRPHLVLLAKDDIEPGEELTYDY 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781	12/90 (13%)
		SET	3590..3710	CDD:214614	41/119 (34%)
PR-Set7	NP_001247100.1	SET	566..676	CDD:279228	40/110 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840