Protein Alignment trx and Su(var)3-9

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_524357.2
• Gene: Su(var)3-9 / 41483
• FlyBaseID: FBgn0263755
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 743
• Identity: 161/743 - (21%)
• Similarity: 273/743 - (36%)
• Gaps: 205/743 - (27%)

  Fly  3069 NRVLPMQQRQEPAPLSNECPVVSSPTPPKPVEQPIIHQMT--SASVSKCYAQKSTLPSPVYEAE- 3130
            ||.|   |:|:.:.|.     ||..||..|  :.|..|.|  ..::......|||:...:...:
  Fly    11 NRNL---QKQDLSNLD-----VSKLTPLSP--EVISRQATINIGTIGHVAHGKSTVVKAISGVQT 65

  Fly  3131 LKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQL---NQQL 3192
            ::..:.||..:                :|..|.|.||      |.:.||..:|||:|.   .:.:
  Fly    66 VRFKNELERNI----------------TIKLERLSEK------KIKNLLTSKQQRQQYEIKQRSM 108

  Fly  3193 VNNGYLLDKHT-FQ---VEPMDTDV---YREEDLEEEEDEDDDFSLKMATSA-------CNDHEM 3243
            :.:...|.:|: |:   .:|..:.:   ....|...........||..:.|:       |.:|::
  Fly   109 LRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDV 173

  Fly  3244 SDSEEPAVKD--KISKILDNLTNDDCADSIATATTMEVDAS---AGYQQMVEDVLATTAAQSAPT 3303
              .:.|::..  |:.:...:.......:|..:...|.|.|.   .| :.:||.:......|..|.
  Fly   174 --DKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKG-EYVVERIECVEMDQYQPV 235

  Fly  3304 --------EEFEGALETAAVEAAATYINEMADAHVLDLKQLQN----GVELELRRRKE-----EQ 3351
                    .:.|...|:.|..|....:.:..:.|    :||..    .:..||.::.|     |.
  Fly   236 FFVKWLGYHDSENTWESLANVADCAEMEKFVERH----QQLYEIYIAKITTELEKQLEALPLMEN 296

  Fly  3352 RTVSQ----EQEQSKAAIVPTA---AAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEI 3409
            .||::    |....:..::..|   ||....|  :||:|: |...|..:|.:.....:...:.::
  Fly   297 ITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQ--REPQKI-GERALKSMQIKRAQFVRRKQLADL 358

  Fly  3410 WEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVE-----------KC 3463
              .:||    .|..|...|.|  |:.....|.:..:.:|.: |:.:.:.|.:           ||
  Fly   359 --ALFE----KRMNHVEKPSP--PIRVENNIDLDTIDSNFM-YIHDNIIGKDVPKPEAGIVGCKC 414

  Fly  3464 SKYTPKYHKRNGNVSTAANGAHGGNLGGSSASA-ALSVSGGDSHGLLDYGSDQDELEENAYDC-A 3526
            ::.|.:.     ..||.......|.|.....|. .|.:..|.:                .|:| :
  Fly   415 TEDTEEC-----TASTKCCARFAGELFAYERSTRRLRLRPGSA----------------IYECNS 458

  Fly  3527 RC---EPYSNRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYRTLKETYKD 3588
            ||   ...|||        |....|:.|:.:|          :...||
  Fly   459 RCSCDSSCSNR--------LVQHGRQVPLVLF----------KTANGS----------------- 488

  Fly  3589 YVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDN---- 3649
                      |.|:.....:..||.|.||.||:|.|...::|.:.||..| ..|:|.:|.|
  Fly   489 ----------GWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNG-RTYLFDLDYNTAQD 542

  Fly  3650 --LVVDATMRGNAARFINHCCEPN-----CYSKVVDILGHKHIIIFALRRIVQGEELTYDY---- 3703
              ..:||...||.:.||||.|:||     |:.:.::: ...|::.|.||.|..||||::||
  Fly   543 SEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNV-ALPHLVFFTLRPIKAGEELSFDYIRAD 606

  Fly  3704 --KFPFED----EKIPCSCGSKRCRKYL 3725
              ..|:|:    .::.|.||:..|||.|
  Fly   607 NEDVPYENLSTAVRVECRCGADNCRKVL 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	16/98 (16%)
		SET_KMT2A_2B	3575..3726	CDD:380947	51/172 (30%)
Su(var)3-9	NP_524357.2	PTZ00327	11..>80	CDD:240362	20/94 (21%)
		Chromo	219..268	CDD:459793	8/48 (17%)
		SET_SUV39H	388..634	CDD:380940	76/314 (24%)