DRSC/TRiP Functional Genomics Resources

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Protein Alignment trx and ash1

DIOPT Version :9

Sequence 1:NP_476769.1 Gene:trx / 41737 FlyBaseID:FBgn0003862 Length:3726 Species:Drosophila melanogaster
Sequence 2:NP_001246834.1 Gene:ash1 / 40133 FlyBaseID:FBgn0005386 Length:2226 Species:Drosophila melanogaster


Alignment Length:1831 Identity:333/1831 - (18%)
Similarity:596/1831 - (32%) Gaps:630/1831 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  2210 SAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYD 2274
            :||.:..|....:|..::..  :.|.:.|..::.:.|.     |..|||.| :.|.        |
  Fly     8 TAAAKVLETQRAQESGSENE--ETDSITDQSSQSKSIK-----SATQFSVQ-RSDT--------D 56

  Fly  2275 AFQRHLPSCSPT--------------MSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAG 2325
            ..:..:.:..||              ||:.:|||..|      .|...:.....:::::.||::.
  Fly    57 GLRMRISAIRPTLGVVATKKPPKSRKMSTQDTESGCS------EAKNRAVSKKVKVKRKKLASSS 115

  Fly  2326 GLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSL 2390
            |::.....:...:                               ||.:..:..:.|||.:..:..
  Fly   116 GISKSDKVSKSKK-------------------------------SQISAFSSDSEDDLPLKVHQQ 149

  Fly  2391 QS----LAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQAT----------TT 2441
            ::    |:|.:....:.::||:.       |.:|::.:      ::|..:||.          ||
  Fly   150 RAPRVLLSAIIQAAQSASKPTLD-------IGISSSDN------ELPNLVQAAIKRVESDTEDTT 201

  Fly  2442 PTATYQ-------------TLQATNTDKKIMLPLTAAGKPLKTVATKAAQ----QAAVKQRQLKS 2489
            ...:::             ||.....:|..||..|...|..:....||.:    |.||.:::...
  Fly   202 VEGSFRKAAKDKNLPQYQSTLLQDFMEKTQMLGQTVNAKLAEEKVAKAKEETLVQTAVPRKRRGR 266

  Fly  2490 GHQVKP-IQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQN 2553
            ..:|.| :.|.....|..::......:..                .|:||:..|.   |:.|.:|
  Fly   267 PKKVVPTVPAPGNSGPAINESADSGVIST----------------TSTTQSTTPS---PKMQNEN 312

  Fly  2554 IISFVTGDGSQGQPLQYISIPTAGEYKPQ-------PQPTATPTFLTTAPGAGATYLQTDASGNL 2611
            .:.  ||           |:|.|...||:       .:..||...|...|.:      .....|.
  Fly   313 AVP--TG-----------SLPIASSSKPKIDMAYLDKRMYATERVLYPPPRS------KRRQNNK 358

  Fly  2612 VLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGL 2676
            ....:.||.       :.||..|             |....|.|:....:...:     |.:||.
  Fly   359 KTACSSSNK-------EELQLDP-------------LWREIDVNKKFRLRSMSV-----GAASGT 398

  Fly  2677 EFATTSPQVILATQPMY---YGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKI 2738
            ..:||....:||.:..|   ||.....:::...:..:.|.|     |..:.:| |.:.:.:.|:.
  Fly   399 GASTTICSKVLAAKSGYVSDYGSVRHQRSSHNHNSGYKSDA-----SCKSRYS-TKSCMSRRSRA 457

  Fly  2739 EPIVDLPAGYVVLNNTGDASSAGTFL---NAASVLQQQTQDDTT--TQILQNANF---------- 2788
            :     ..||  .::..::..:|..:   ..||:|.:.:.|||.  ..|||.|..          
  Fly   458 K-----SCGY--RSDCKESGKSGLRMRRKRRASMLLKSSADDTVEDQDILQLAGLSLGQSSEESN 515

  Fly  2789 ------QFQSVPTSS------------------GASTSMDYTSPVMVTAKIPPVTQIKRTNAQAK 2829
                  ..:|:||:|                  |...|:..|:|....:|:  :.|.|.|.|.:|
  Fly   516 EYISKPSLKSLPTTSASKKYGEINRYVTTGQYFGRGGSLSATNPDNFISKM--MNQRKETPAPSK 578

  Fly  2830 ----------------AAGISGVGKVPPQPQ-----------VVNKVL-PTSIVTQ--QSQVQVK 2864
                            ::.:|||.::..:.:           :.:|:| ...|:|.  .|:.:::
  Fly   579 SSCKIKSRRSSAASMCSSYVSGVSRMRRRHRRKSFSHNKSLNIDSKLLTEIEIITSTFNSRCRIQ 643

  Fly  2865 NSNLKQSQVKGK----------------AASGTGTTCGAPPSIASKPLQ---KKTNMIRPIHKLE 2910
            :..|..|..|.|                .|.......|.|.|..||||:   ||..:..|:....
  Fly   644 DDRLTGSSGKEKLLADANKLQATLAAPSPAQQLTLNGGGPASTLSKPLKRGLKKRKLSEPLVDFA 708

  Fly  2911 VKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQ 2975
            :.......||.....::...:::.::........|            ...::|       |::..
  Fly   709 MLSASASGTPNGSGSSNGNTKRRHKKSQSNDSSSP------------DDHKLP-------LKKRH 754

  Fly  2976 MIHIPQQQQPLQQQQVQVQPSMPIITLAEAPV-------VQSQF-------VMEPQALEQQELAN 3026
            .:..|.::.|.:......:.:......|.|..       .|:||       .:.|:.....|...
  Fly   755 YLLTPGERPPAEVAFANGKLNAEAWAAAAAAAKSTASTKSQAQFNARSVKSALTPKKRHLLEQPT 819

  Fly  3027 RVQHFSTSSSSSSSNCSLPTNVVN--PMQQQAPSTTSSSTTRPTNRVLPMQQR----QEPAPLSN 3085
            .|....:|:|:|.....:..|.::  .:...:||:..|         |..|:|    ::....:.
  Fly   820 SVSGAGSSASNSPLRIVVDNNSISGGKLLDISPSSLCS---------LKQQRRGGAAKQKVSAAK 875

  Fly  3086 ECPVVSSPT---PPKPVEQPIIH---QMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDV 3144
            :...:.||.   ||..|.:|.:.   |:..:.:::....|:.:.||:..|            .|:
  Fly   876 DLVQLQSPAGSYPPPGVFEPSVELEIQIPLSKLNESVITKAEVESPLLSA------------LDI 928

  Fly  3145 TMDAILE-EQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGY---LLDKHTFQ 3205
            ..|...| .|.|.|::.            .||...||.:::|:::|:    .|:   ...|....
  Fly   929 KEDTKKEVGQRVVETLL------------HKTGGNLLLKRKRKKINR----TGFPTVRRKKRKVS 977

  Fly  3206 VEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADS 3270
            ||...|.|..|.:.|.:.|::...||:...|:.|                               
  Fly   978 VEQQTTAVIDEHEPEFDPDDEPLQSLRETRSSNN------------------------------- 1011

  Fly  3271 IATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYI---NEMAD-AHVL 3331
                                     ...|:||....:......|.||..|::   |:.|. ..|:
  Fly  1012 -------------------------VNVQAAPNPPLDCERVPQAGEARETFVARTNQKAPRLSVV 1051

  Fly  3332 DLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPP------------------QPI 3378
            .|::||. .:...|.|...::..::||.:         |||:||                  ||:
  Fly  1052 ALERLQR-PQTPARGRPRGRKPKNREQAE---------AAPQPPPKSEPEIRPAKKRGRQPKQPV 1106

  Fly  3379 QEPKKMTGP------HLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAH---GLTPLPEGPL 3434
            .|....|.|      .:...|:..||....::...:|        ::.||.:   |..|..|.|:
  Fly  1107 LEEPPPTPPPQQKKNKMEPNIRLPDGIDPNTNFSCKI--------RLKRRKNLEAGTQPKKEKPV 1163

  Fly  3435 ADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALS 3499
            ..:               .:|::|         |:.......:...|......::  .:....|.
  Fly  1164 QPV---------------TVEEIP---------PEIPVSQEEIDAEAEAKRLDSI--PTEHDPLP 1202

  Fly  3500 VSGGDSHGLLDYGSDQDELEENAYDCA-------------------------------------- 3526
            .|...:.|..||.|..:..|:.|...:                                      
  Fly  1203 ASESHNPGPQDYASCSESSEDKASTTSLRKLSKVKKTYLVAGLFSNHYKQSLMPPPAKVNKKPGL 1267

  Fly  3527 --------------RCEPYSNRSE------YDMF---------------SWLASRHRKQPIQVF- 3555
                          .||.|..|:|      ||::               ||   .:||....|: 
  Fly  1268 EEQVGPASLLPPPPYCEKYLRRTEMDFELPYDIWWAYTNSKLPTRNVVPSW---NYRKIRTNVYA 1329

  Fly  3556 --VQPS--------------------D---NELVPRRGTGSNLPMAMKYRTLK-ETYKDYVGV-- 3592
              |:|:                    |   |.:|....:.||.|...|.|..| :.:....||  
  Fly  1330 ESVRPNLAGFDHPTCNCKNQGEKSCLDNCLNRMVYTECSPSNCPAGEKCRNQKIQRHAVAPGVER 1394

  Fly  3593 FRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYM-------FKIDDNL 3650
            |.:...|.|:.....|..|..::||.||::       .|:.:..|....|:       ..:|..|
  Fly  1395 FMTADKGWGVRTKLPIAKGTYILEYVGEVV-------TEKEFKQRMASIYLNDTHHYCLHLDGGL 1452

  Fly  3651 VVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKF----PFEDEK 3711
            |:|....|:..||:||.|||||..:...:.|...:::||.|.|.:||||||||.|    |.|.: 
  Fly  1453 VIDGQRMGSDCRFVNHSCEPNCEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQ- 1516

  Fly  3712 IPCSCGSKRCR 3722
             ||.|.:.:||
  Fly  1517 -PCRCNTPQCR 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trxNP_476769.1 NR_DBD_like 762..>856 CDD:295381
PHD1_KMT2A_like 1268..1344 CDD:276981
PHD 1346..1390 CDD:214584
PHD3_KMT2A_like 1423..1479 CDD:276983
ePHD_KMT2A_like 1737..1841 CDD:277134
FYRN 1891..1935 CDD:283589
FYRC 3388..3476 CDD:197781 13/90 (14%)
SET 3590..3710 CDD:214614 44/132 (33%)
ash1NP_001246834.1 AWS 1340..1388 CDD:197795 9/47 (19%)
SET 1392..1512 CDD:214614 41/126 (33%)
Bromo_ASH1 1680..1787 CDD:99955
PHD_ASH1L 1858..1900 CDD:277023
BAH_polybromo 1929..2073 CDD:240068
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45467644
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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