DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and g2e3

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001003822.1	Gene:	g2e3 / 368848	ZFINID:	ZDB-GENE-030616-400	Length:	706	Species:	Danio rerio

Alignment Length:	755	Identity:	147/755 - (19%)
Similarity:	243/755 - (32%)	Gaps:	268/755 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1725 SCGIKMRLDTRMCLFCRKSGEGLS--GEEARLLYCGHDCWVHTNCAMWSA------EVFEEIDGS 1781
            |..||::....:|..|::|.....  ||:..|..  |:..||..|.:.|:      |..|::.|.
Zfish     8 SAEIKLQDRDLICCLCKRSENNKEKYGEKVHLEQ--HNLAVHFFCLLMSSGICQRGEEDEDVYGF 70

  Fly  1782 L-QNVHSAVARGRMIKCTVCGNRGATVGCNVRSCGEHYHYPCARSIDCAFLTDK--SMYCPAHAK 1843
            | .::...:.|...::|..|...||:|||:::||.:..|.||....:..|....  ..:|..||
Zfish    71 LVGDIKKEIRRSSRLRCFHCKKAGASVGCSIKSCRQMVHMPCGLEQEFVFQFTGLFPSFCKKHA- 134

  Fly  1844 NGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKLIEPARVQFHI-------GS---------- 1891
                      |:.:.:|:..:.....:.||.     |||. :.:|:       ||
Zfish   135 ----------PTQSCDSSHSLPHSCSICLDP-----IEPI-LSYHVLKCPACHGSWFHRKCVQNY 183

  Fly  1892 ---------------------LEVRQLGAIVPRFSDSYE----AVV----------PINFLC--S 1919
                                 .|:.::|..:|....|:|    |.|          .:..||  .
Zfish   184 AHSAAMFFFKCTLCNNKEQFQQEMLRMGIYIPERDASWELEENAFVELLQVYHRCDAVKCLCHKG 248

  Fly  1920 RLYWSSKEPWKIVEYTV---RTTIQNSSSTLTALDVGRNYTVD------------HTN---PNSK 1966
            |.:.|....::||...:   |.|.:..|:.       |.|..|            .|:   ||..
Zfish   249 REHSSQSGYFEIVLCKLCGSRGTHRKCSNI-------RVYEADWMCADCKTAAEGKTSLPLPNHV 306

  Fly  1967 EVQLGMAQ--------IARWHTSLARSEFLENGGTDWSGEFPNPNSCVPP-------DENTEEEP 2016
            |..|.:.|        |:..|:|:...                 ..|||.       |...:...
Zfish   307 ESPLAIRQERKRLFKSISDIHSSIVAK-----------------RQCVPATSPEVLMDLACQISQ 354

  Fly  2017 QQQADLLPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQ-SKDGTQAMTSNQAQNQN 2080
            ||..::|..:....:.|          :.|.:....|......:|.: |||    ..:|..:||.
Zfish   355 QQFTEVLVGDDDGGVME----------AALQVLRQSDFNPCCTLSVKFSKD----KLNNNIRNQR 405

  Fly  2081 ----------------QQAGGANSVSICDEDTRNS---------NTSLGNGWPASN--------- 2111
                            :.:.||.::::..:..|:.         ..||.:|.|...
Zfish   406 RFLRRLVSKLQVSDIFEGSDGAKNLALNSKALRDDLYFDVGSLLALSLVHGGPPLGFFSPALYHS 470

  Fly  2112 ----------PVED----AMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSK-----NL 2157
                      .:||    |.....|..::.:.:|.|.......:..:..|...||:||     .|
Zfish   471 LFNYPKNYRPTLEDLGDTAFGHKIRQIAEAKSMKELRHAMKSASQYLEAAGCWRKISKLSEKDML 535

  Fly  2158 AEGV---FLTLSSQ---QRNKKEMATVAGVSRRQSISET---------------SVEGVATTSGS 2201
            .|.|   :|.:..|   ||.::.:.|:....:.|..|||               ||..:.||..|
Zfish   536 VEDVLNFYLIIRLQLPLQRFREGLRTLGMFEQVQMCSETFFPVFCGPVERLTAESVMELFTTRLS 600

  Fly  2202 ------VRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSIT-----------------EF 2243
                  |..|: |.|..|:|..:.|..:.||.:        :|.:|                 ..
Zfish   601 EEKEKQVLEKT-TISFWKQYLHECEEGQCAASL--------EDLLTFATGTDLVPAIGFKPTPSI 656

  Fly  2244 RIISGDGNLSTAQFSGQVKCDRCQC---TYRNYDAFQRHL 2280
            ..:|...||....   |..||....   |..:|..|::||
Zfish   657 SFLSSPDNLCAFP---QSNCDANHLILPTLPSYQLFKKHL 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	30/114 (26%)
		FYRN	1891..1935	CDD:283589	14/90 (16%)
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
g2e3	NP_001003822.1	ePHD_PHF7_G2E3_like	20..133	CDD:277139	30/114 (26%)
		PHD_PHF7_G2E3_like	237..290	CDD:276971	12/59 (20%)
		HECTc	433..695	CDD:294058	55/273 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810