Protein Alignment trx and set-25

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_499738.3
• Gene: set-25 / 3565129
• WormBaseID: WBGene00012802
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 815
• Identity: 157/815 - (19%)
• Similarity: 265/815 - (32%)
• Gaps: 295/815 - (36%)

  Fly  3020 EQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQ---------QQAPSTTSSSTTRPTNRVLPMQ 3075
            |.|.|..|.:..:|.::.||..    .||:...:         |.||||::.....|..     .
 Worm    75 ETQRLRQRRRISATDATQSSRT----MNVIEDRKPRVNRARKSQDAPSTSTCGFETPVG-----T 130

  Fly  3076 QRQEPAPLSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCY------AQKSTLPSPVYEAELKVS 3134
            :|:..|        ..|..|||   |..:.::..||.||..      .:|:|.|: |.::..:.|
 Worm   131 KRKSKA--------ADSQKPPK---QSKLRKIDEASTSKAVDNSSKDGKKTTKPA-VTQSNRRRS 183

  Fly  3135 SVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTE-QLLLQQQQREQLNQQLVNNGYL 3198
            .:....||             .|:|::|     :|..||.|| :..:..|||.   :::..|..:
 Worm   184 GLSLRPVP-------------IETIFSE-----SSGRESSTEDEADVSHQQRV---EKIAKNPIM 227

  Fly  3199 LDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEE---------PAVKDK 3254
            :     .|.|:....|..   .|.......:..:: ...||:...:....         |.:..|
 Worm   228 V-----VVLPLGPGNYPN---NERITVVSTYKSRV-NKNCNEARRAQRHGSWSRKGIAFPGIPTK 283

  Fly  3255 ISKILDNLTNDDCADSIATATTMEVDASAGYQQMVEDVL---------------ATTAAQSAPT- 3303
                  ..|..|.|...|.|:..  .|.|.::.....:|               ....|::|||
 Worm   284 ------KFTKSDLAKYGAHASNW--PAQAAFRSEEGKILIYYEGWTCLTLHRLSVEECARTAPTI 340

  Fly  3304 -------EEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQS 3361
                   ::|...:::||.|.|...:.          |..:||:||.|             .|..
 Worm   341 LEEMSIRDKFIETVKSAAAEEAKLVVE----------KNQENGIELTL-------------DEAL 382

  Fly  3362 KAAIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGL 3426
            |...:             ||...:.|..::.|..:..:.:...:                |..||
 Worm   383 KQIFI-------------EPVPQSSPENVFWIYQDLSYFHTMDN----------------RDLGL 418

  Fly  3427 TPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTP------KYHKRNGNVSTAANGAH 3485
            .|           :..|...|.:::         ..|..||.      ..:||  .:.:.||
 Worm   419 AP-----------VFYISSYTQSVR---------PPCYAYTAINIVDVDAYKR--CLESRAN--- 458

  Fly  3486 GGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQ 3550
                          :|..|..|...:...:.:..||...| :|:.        .|.:|...|...
 Worm   459 --------------MSFADLTGQKIWMPTRSKACENGTKC-KCDA--------RFMFLYDPHDVT 500

  Fly  3551 PIQVFVQPS----------DNELV--------------PRRG--TGSNLPMAMKYRTLKETYKDY 3589
            .::  ..|.          ||..:              |||.  .|...|:|:.|...::
 Worm   501 NLE--CTPDGKVDFTDFKIDNARIVMECSDACGCSLDCPRRSLQRGQQHPLAVYYEGPEK----- 558

  Fly  3590 VGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELI----------RSTLTDKRERY----------- 3633
                     |.|:....:|:|||:|.||.|::.          .||.||..|..
 Worm   559 ---------GFGVRAAANIKAGELVCEYTGDVTLLPTSDPVASSSTKTDDGEEQENPEAPERVDS 614

  Fly  3634 -YDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHK--------HIIIFA 3689
             ||:.     ...:|..:::.|...||.:|||||.|:|:  |..|::...:        .:.::|
 Worm   615 SYDAA-----FNAMDTKIIISAKKTGNISRFINHSCDPS--SVFVEVYSRRFEEDPLIPRVAVYA 672

  Fly  3690 LRRIVQGEELTYDYKFP---FEDEKIPCSCGSKRC 3721
            ::.|..|||:|..|..|   ::...:.|.|.|.:|
 Worm   673 IKDIALGEEITIAYYEPGIEWKRSSVKCRCKSTKC 707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	12/93 (13%)
		SET_KMT2A_2B	3575..3726	CDD:380947	44/180 (24%)
set-25	NP_499738.3	SET	<525..711	CDD:394802	49/204 (24%)