DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trx and Set1

DIOPT Version :9

Sequence 1:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster
Sequence 2:	NP_001015221.1	Gene:	Set1 / 3354971	FlyBaseID:	FBgn0040022	Length:	1641	Species:	Drosophila melanogaster

Alignment Length:	1382	Identity:	274/1382 - (19%)
Similarity:	460/1382 - (33%)	Gaps:	383/1382 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2498 AKLQPHPQQHQQQQQTQVQ---QPITVMGQNLLQPQ--LLFQSSTQTQAPQII--------LPQA 2549
            ||||| |........|::|   ||.:..|...|..:  |:|:..|...||..:        ..|.
  Fly   490 AKLQP-PVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFKGKTFGNAPPFLQMDSSDSETDQG 553

  Fly  2550 QPQNIISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLT 2614
            :|: :.|.|..|.:..:..:. |.....:...||...                  :|.|.:..|.
  Fly   554 KPE-VFSDVNSDSNNSENKKR-SCEKNNKVLHQPNEA------------------SDISSDEELI 598

  Fly  2615 TTPSNSGLQMLTAQSLQAQPQVIGTL-IQPQTIQLGGGADGNQ-------PGSNQQPLILGGTGG 2671
            .....|.|.::..:.:......:.:| .|...||...||:...       ..|||.|.....:|.
  Fly   599 GKKDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQTKEGAEYKSIMSSYMYSHSNQNPFYYHASGY 663

  Fly  2672 GS--SGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMP-----GMLS-QNASFSAT 2728
            |.  ||:...:.|.   |.:...|...|.:   ..::|..|.|.:.|     |.|| ||......
  Fly   664 GHYLSGIPSESASR---LFSNGAYVHSEYL---KAVASFNFDSFSKPYDYNKGALSDQNDGIRQK 722

  Fly  2729 TTQVFQASKIEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQF--- 2790
            ..||.             ||:|                 ..|:|..:.|...::::...|:.
  Fly   723 VKQVI-------------GYIV-----------------EELKQILKRDVNKRMIEITAFKHFET 757

  Fly  2791 ---------QSVP----TSSGASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAA---GISGVG-- 2837
                     :|.|    ..|..:|.::.........|.|.:..:  .||..:.|   ..|.:|
  Fly   758 WWDEHTSKARSKPLFEKADSTVNTPLNCIKDTSYNEKNPDINLL--INAHREVADFQSYSSIGLR 820

  Fly  2838 ----KVP--------PQPQVVNKVLPT-------SIVTQQSQVQVKNSNLKQSQVKGKAASGTGT 2883
                |:|        |.|      :||       .:..|:..||..:|:.:.|.|:
  Fly   821 AAMPKLPSFRRIRKHPSP------IPTKRNFLERDLSDQEEMVQRSDSDKEDSNVE--------- 870

  Fly  2884 TCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQPQLQQQIPAVV 2948
                    .|...:.|.....||.:.:.|........|.:....|.......   ....:.....
  Fly   871 --------ISDTARSKIKGPVPIQESDSKSHTSGLNSKRKGSASSFFSSSSS---STSSEAEYEA 924

  Fly  2949 VNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFV 3013
            ::.|.|...|::..|....|:.|.|
  Fly   925 IDCVEKARTSEEDSPRGYGQRNLNQ---------------------------------------- 949

  Fly  3014 MEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRPTNRVLPMQQRQ 3078
             ....:..:.|...:...:..:..|.||.....||....::...|.|.....|   .:.|..:.:
  Fly   950 -RTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKNIYSDTDEDNDR---TLFPALKEK 1010

  Fly  3079 EPAPLSNECPVVSSPT----PPKPVEQPIIHQM--TSASVSKCYAQKSTLPSPVYEAELKVSSVL 3137
            ..:.:.::...:|..:    ....:|..|:.::  |.....:|....:.:|.|.|..|
  Fly  1011 NISTILSDLEEISKDSCIGLDENGIEPTILRKIPNTPKLNEECRRSLTPVPPPGYNEE------- 1068

  Fly  3138 ESIVPDVTMDAILEEQPVTE--SIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLD 3200
                 ::......:::|..|  .||::...||......|.....:.|.:||.|.:|.......||
  Fly  1069 -----EIKKKVDCKQKPSFEYDRIYSDSEEEKEYQERRKRNTEYMAQMEREFLEEQEKRIEKSLD 1128

  Fly  3201 KHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTND 3265
            |:   ::..:..|........:.||....::.. |.:|  .|.:...:..:.:.||  ::|..|:
  Fly  1129 KN---LQSPNNIVKNNNSPRNKNDETRKTAISQ-TRSC--FESASKVDTTLVNIIS--VENDINE 1185

  Fly  3266 ----DCADSIATATTMEVDASAGYQQMVEDVLATTAAQSAPTEEFEGALETA-AVEAAATYINEM 3325
                :..|.:..........|.|..:..:..:.:....|..::..:.|||.. ::...:..:.:.
  Fly  1186 FGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHSVSLGDY 1250

  Fly  3326 ADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQP----IQEPKKMTG 3386
            ....|.:.|.:       |:|..|....|||          .|...|..|:.    ||:.|:...
  Fly  1251 PSGKVNETKNI-------LKREAENIAIVSQ----------MTRTGPGRPRKDPICIQKKKRDLA 1298

  Fly  3387 PHL----------------------------LYEIQSEDG-----FTYKSSSITEIWEKVFEAVQ 3418
            |.:                            :|:.:.::.     :|:.:..|..      |.:.
  Fly  1299 PRMSNVKSKMTPNGDEWPDLAHKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDA------EDIN 1357

  Fly  3419 VARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSK----YTPKYHKRNGNVST 3479
            ..:.:: |..|.:.|.|                ..:.....|:.|:.    :.|...||.
  Fly  1358 FIKMSY-LDHLHKEPYA----------------MFLNNTHWVDHCTTDRAFWPPPSKKRR----- 1400

  Fly  3480 AANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARCE--------------- 3529
                                              ..|||..:...|||.|
  Fly  1401 ----------------------------------KDDELIRHKTGCARTEGFYKLDVREKAKHKY 1431

  Fly  3530 PYSNRSEYDMF--------SWLASRH------RKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYR 3580
            .|:..:..|.|        :.|.:.|      :.|.|....:.:...|:...|:.....: :|:.
  Fly  1432 HYAKANTEDSFNEDRSDEPTALTNHHHNKLISKMQGISREARSNQRRLLTAFGSMGESEL-LKFN 1495

  Fly  3581 TLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIG-CYMF 3644
            .|| ..|..:...:|.||..||:..:.|.|.||||||.|::||..:.|.||..|::.||| .|:|
  Fly  1496 QLK-FRKKQLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIGSSYLF 1559

  Fly  3645 KIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFED 3709
            :||...::|||..||.||||||.|.||||:||:.|...|.|:|::.:.|...||:|||||||.||
  Fly  1560 RIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEITYDYKFPLED 1624

  Fly  3710 EKIPCSCGSKRCRKYLN 3726
            |||||.||::.||..||
  Fly  1625 EKIPCLCGAQGCRGTLN 1641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781	13/124 (10%)
		SET	3590..3710	CDD:214614	60/120 (50%)
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:240750
		DUF1777	255..>380	CDD:285811
		PRP38_assoc	<318..388	CDD:289628
		N-SET	1341..1492	CDD:288597	28/213 (13%)
		SET	<1463..1641	CDD:225491	78/179 (44%)
		SET	1504..1625	CDD:214614	60/120 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467645
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840