Protein Alignment trx and Set2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_572888.2
• Gene: Set2 / 32301
• FlyBaseID: FBgn0030486
• Length: 2362
• Species: Drosophila melanogaster
• Alignment Length: 2035
• Identity: 381/2035 - (18%)
• Similarity: 653/2035 - (32%)
• Gaps: 738/2035 - (36%)

  Fly  1841 HAKNG-----------NALKANGSPSVTYE---SNFEVSR---------PVYVEL---DRKRKKL 1879
            |:::|           .|..|:.|.:.|..   |.||:|.         |..:|:   .|..:.|
  Fly   104 HSQSGTTAASTSMSTATASAASASSAATVSRLFSMFEMSHQSLPPPPPPPTALEIFAKPRPTQSL 168

  Fly  1880 I------EPARVQFHIGSLEVRQLGAIVP------------RFSDSYEAVVPINFL--CSRLYWS 1924
            |      ||:.|.   |:..|:.:..:.|            :.:|:  |::|...:  ||....:
  Fly   169 IVAQVTSEPSAVG---GAHPVQTMAGLPPVTPRKRGRPRKSQLADA--AIIPTVIVPSCSDSDTN 228

  Fly  1925 SKEPWKIVEYTVRTTIQNSSSTLTALDVGRNYTVDHTNPNSKEVQLGMAQIARWHTSLARSEFLE 1989
            |          ..||..|.||     |.|.........|.||           ...||.|   |:
  Fly   229 S----------TSTTTSNMSS-----DSGELPGFPIQKPKSK-----------LRVSLKR---LK 264

  Fly  1990 NGG---TDWSGEFPNPNS--CVPP---DENT-EEEPQQQADLLPPELKDAIFEDLPHELLDGISM 2045
            .||   :..||..|:.:|  ..||   |||. :|.|:|:.:|  ..:.||      .|..|..|.
  Fly   265 LGGRLESSDSGNSPSSSSPEVEPPALQDENAMDERPKQEQNL--SRMVDA------EENSDSDSQ 321

  Fly  2046 LDIFLYDDKTDLFAISEQSKDGTQAMTSNQAQNQNQQAGGANSVSICDEDTRNSNTSLGNGWPAS 2110
            : ||:        .|..:|..|          .:.|:.|  ..|.:..:|..:.:..|....|..
  Fly   322 I-IFI--------EIETESPKG----------EEEQEEG--RPVEVEPQDLIDIDMELAKQEPTP 365

  Fly  2111 NPVEDAMLSAARNSSQVQMLK--TLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKK 2173
            :|.||.      :...|::|.  ...|...|.......|..:|..... .|....:.||..|..:
  Fly   366 DPEEDL------DEIMVEVLSGPPSLWSADDEAEEEEDATVQRATPPG-KEPAADSCSSAPRRSR 423

  Fly  2174 EMATVAGVSRR-QSISETSVEGVATTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVD 2237
            ..|.::|.||: :::.||..|..|.:|..:...           |:|:.:||    :.:.:|.::
  Fly   424 RSAPLSGSSRQGKTLEETFAEIAAESSKQILEA-----------EESQDQEE----QHILIDLIE 473

  Fly  2238 DSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSGQG-M 2301
            |:::|..:.|                                  |.|||:.....|..|..:. :
  Fly   474 DTLSESEVTS----------------------------------SVSPTIEHMVVEEVVVEENQL 504

  Fly  2302 TNNATQISAESLNELQKQLLANAGGLNYLQSATSF-PQVQSLGSLGQFGLQGLQQLQLQPQSLGS 2365
            .:.|.:|.......:.|::.:.:..:....:...| |:|::..:.|:.
  Fly   505 VDEADEILDSKQEFVIKKVFSESDNIAASLNKDIFEPKVETKATCGEV----------------- 552

  Fly  2366 GFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFI 2430
                 .|.|  :..|:|:.|    .:.:||.|.....:.:||....|:.:|
  Fly   553 -----VPRP--EMVTEDVYI----TEGIAATLEKSAVVTKPTTEMIAETKL-------------- 592

  Fly  2431 QIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKP 2495
                                   :|:.::.|      |||
  Fly   593 -----------------------SDEVVIEP------PLK------------------------- 603

  Fly  2496 IQAKLQPHPQQHQQQQQTQVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIISFVTG 2560
                      .....:||:|:.|.:....|:.:.:.:..:..:|.:..::.|:.        .|.
  Fly   604 ----------DESDPKQTEVELPESKPAVNIPKSERILSAEVETTSSPLVPPEC--------CTL 650

  Fly  2561 DGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTA----PGAGATYLQTDASG-----NLVLTTT 2616
            :...|..|...|:.|  |.|.......||.....|    |.|..   :.:||.     |.:|...
  Fly   651 ESVSGPVLLETSLST--EEKSNENVETTPLKTEAAKEDSPPAAP---EEEASNSSEEPNFLLEDY 710

  Fly  2617 PSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSGLEFATT 2681
            .||        |...|:.:::..              .||.|..|.||
  Fly   711 ESN--------QEQVAEDEMMKC--------------NNQKGQKQTPL----------------- 736

  Fly  2682 SPQVILATQPMYYGLETI------VQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASK--- 2737
             |::....:|:   .||:      ::|...||        |.::.:.........:|.:::|
  Fly   737 -PEMKEPEKPV---AETVSKKEKAMENPARSS--------PAIVDKKVRAGEMEKKVVKSTKGTV 789

  Fly  2738 IEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTS 2802
            .|..:|.......:.......|..:...|  :|:::|:.:.                    :|..
  Fly   790 PEKKMDSKKSCAAVTPAKQKESGKSAKEA--ILKKETEKEK--------------------SSAK 832

  Fly  2803 MDYTSPVMVTAK-------IPPVTQIKRTNAQAKAAGISGVGKVPPQ---PQVVNKVLPTSIVTQ 2857
            :|.:||..:..|       .|.:..:.:::.:            |||   |.|::|........:
  Fly   833 LDSSSPNTLDKKGKDTAQWSPQLQTLPKSSTK------------PPQESAPSVISKTTSNQPAPK 885

  Fly  2858 QSQVQVK-----NSNLKQSQVKGKAASGTGTTCGA---PPSIASKPL---QKKTNMIRPI-HKLE 2910
            :.|...|     ||.....:.|.||.||. ..|.|   ...:|:..|   :|....::.: .|:|
  Fly   886 EEQHAAKKGLSDNSPPSVLKAKEKAVSGF-VECDAMFKAMDLANAQLRLDEKNKKKLKKVPTKVE 949

  Fly  2911 VKPKVMKPTP-KVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQA 2974
            ..|||..||. .|..|..||..:...::..:.:..|.:..|..|    |.....|.|...:|:.:
  Fly   950 APPKVEPPTAVPVPGQKKSLSGKTSLRRNTVYEDSPNLERNSSP----SSDSAQANTSAGKLKPS 1010

  Fly  2975 QMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSS 3039
            ::             :.::.|...  |:.||                           .....||
  Fly  1011 KV-------------KKKINPRRS--TICEA---------------------------AKDLRSS 1033

  Fly  3040 SNCSLPTNVVNPMQQQAPSTTSSS-------TTRPTNRVLPMQQRQEPAPLSNECPVVSSPTPPK 3097
            |:.|.||..|......:.|:.|||       ||...:....:.||:        ..:.....|..
  Fly  1034 SSSSTPTREVAASSPVSTSSDSSSKRNGSKRTTSDLDGGSKLDQRR--------YTICEDRQPET 1090

  Fly  3098 PVEQPI------IHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDAILEEQPVT 3156
            .:..|:      :|...||             :|::                   |.:|:
  Fly  1091 AIPVPLTKRRFSMHPKASA-------------NPLH-------------------DTLLQ----- 1118

  Fly  3157 ESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDVYREEDLEE 3221
                |.|  :|....|.|           |.|::|               ..:|:.
  Fly  1119 ----TAG--KKRGRKEGK-----------ESLSRQ---------------NSLDSS--------- 1142

  Fly  3222 EEDEDDDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCADSIATATTMEVDA----S 3282
                                  |.:.:.|.|.|..|          :..|.:|..:|.::    |
  Fly  1143 ----------------------SSASQGAPKKKALK----------SAEILSAALLETESSESTS 1175

  Fly  3283 AGYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRR 3347
            :|.:....||      |::|  |.|.|             |...|.    .|.:::||.| |:|.
  Fly  1176 SGSKMSRWDV------QTSP--ELEAA-------------NPFGDI----AKFIEDGVNL-LKRD 1214

  Fly  3348 K--EEQRTVSQEQEQSKA-----------AIVPTAAAPEPPQPIQEPKKMTGPHLLYEIQSEDGF 3399
            |  |:||...|::.:.:|           |.:.|.|....|.|.|.             ..||
  Fly  1215 KVDEDQRKEGQDEVKREADPEEDEFAQRVANMETPATTPTPSPTQS-------------NPED-- 1264

  Fly  3400 TYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMG-GIQMIGLKTNALKYLIEQLPGVEKC 3463
               |:|.|.:. |..|.....||:|.:...|:||.|..| |:..:.|...::...:.:|..:|
  Fly  1265 ---SASTTTVL-KELETGGGVRRSHRIKQKPQGPRASQGRGVASVALAPISMDEQLAELANIE-- 1323

  Fly  3464 SKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGDSHGLLDYGSDQDELEENAYDCARC 3528
                                             |::.....|.||..:    ..|:||.|.|||.
  Fly  1324 ---------------------------------AINEQFLRSEGLNTF----QLLKENFYRCARQ 1351

  Fly  3529 EPYSN-RSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNL----------PMAMK-YRT 3581
            ....| ..:.|.|                ...|.|.......|:..          |:... .|.
  Fly  1352 VSQENAEMQCDCF----------------LTGDEEAQGHLSCGAGCINRMLMIECGPLCSNGARC 1400

  Fly  3582 LKETYKDY----VGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYD-SRGIGC 3641
            ..:.::.:    ..|||:...|.|:.....|..||.::||.||:|.|...::|:..|. .|....
  Fly  1401 TNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVGEVIDSEEFERRQHLYSKDRNRHY 1465

  Fly  3642 YMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKF- 3705
            |...:....|:|||.:||.:|:|||.|:||..::...:.|...|..|:::.|..|||:|:||::
  Fly  1466 YFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWTVNGELRIGFFSVKPIQPGEEITFDYQYL 1530

  Fly  3706 PFEDEKIPCSCGSKRCRKYL 3725
            .:..:...|.|.:..||.::
  Fly  1531 RYGRDAQRCYCEAANCRGWI 1550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	381/2035 (19%)
		FYRN	1890..1937	CDD:461787	9/60 (15%)
		FYRC	3388..3476	CDD:197781	19/88 (22%)
		SET_KMT2A_2B	3575..3726	CDD:380947	46/158 (29%)
Set2	NP_572888.2	valS	<709..832	CDD:237855	27/195 (14%)
		AWS	1358..1410	CDD:197795	7/67 (10%)
		SET_SETD2	1410..1551	CDD:380949	45/141 (32%)
		WW	2014..2043	CDD:459800
		SRI	2266..2355	CDD:462404