Protein Alignment trx and Setd2

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001388092.1
• Gene: Setd2 / 316013
• RGDID: 1305576
• Length: 2535
• Species: Rattus norvegicus
• Alignment Length: 2016
• Identity: 356/2016 - (17%)
• Similarity: 641/2016 - (31%)
• Gaps: 662/2016 - (32%)

  Fly  1937 RTTIQNSSSTLTALDVGRNYTVDH--------TNPNSKEVQLGMAQIARWHTSLARSEFLENGGT 1993
            :.|:||  ...|||...:.....|        :||.:|                     :|.|.|
  Rat    81 KKTLQN--RFFTALSNEKQSDSPHSPATPQVDSNPKAK---------------------MEAGDT 122

  Fly  1994 DWSGEFPNPNSCVPPDENTE--------------EEPQ-----QQADLLPPELKDAIFEDLPHEL 2039
                 ||......||....|              ..||     ..|.||||..:      ||
  Rat   123 -----FPATEESSPPKSRVELGRIHFKKHLLHVTSRPQLATTTTVASLLPPTTQ------LP--- 173

  Fly  2040 LDGISMLDIFLYDDKTDLFAISEQSKDGTQAM-----TSNQAQNQNQQAGGANSVSICDEDTRNS 2099
                              .||:|.:.|...:.     ...|..:.:..|..:..|::.....
  Rat   174 ------------------VAIAESTVDSPPSSPPPPPPPPQVSSPSPPAPISEPVALPHPPV--- 217

  Fly  2100 NTSLGNGWPASNPVEDAM-------LSAARNSSQVQMLKTLAWPKLD----------GNSAMATA 2147
             |:|....|...||:.|:       :.:...|.::.|.:.:....|:          .::|:...
  Rat   218 -TALMTSTPGPLPVDAAVRAQKEPPMKSVPESLELDMKQDIVSNSLEEHTNQTLKEQADNALQKE 281

  Fly  2148 IKRRKLSKNLAEGVFLTLSSQQ-RNKKEMATVAGVSRRQSISETSVEGVATTSGSVRS---KSFT 2208
            .......:.:::|..::|||:: .:||:.:...|........|.||.    ||.|.||   ||.|
  Rat   282 DSHIGKEEEVSDGSKISLSSKKASSKKKSSQFEGTFLGSESDEDSVR----TSSSQRSHDLKSST 342

  Fly  2209 WSAAKRYFEKSE--------GREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDR 2265
            ....:|.|:||.        |:...:|..      .||....:..:..|    |...|.:.:.:|
  Rat   343 SIEKERDFKKSSAPSKSEDLGKSSRSKTE------RDDKYFSYSKLERD----TRYVSTRCRSER 397

  Fly  2266 CQCTYRN----------------------YDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQI 2308
            .:...|:                      ||:.:|:      ..||...|.....:..|:|..:.
  Rat   398 DRRRSRSRSRSDRVSRTSLSYSRSERSHYYDSERRY------HRSSPYRERTRYSRPYTDNRARE 456

  Fly  2309 SAESLNELQKQLLANAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPN 2373
            |::|.:|.:|......       ||.|:..:::..|..:|                        :
  Rat   457 SSDSEDEYKKTYPRRT-------SAHSYRDLRTSSSYSKF------------------------D 490

  Fly  2374 PATQANTDDLQI-----YANSLQSLAANLGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIP 2433
            ...:..|..|::     |::.|:..:..              .::.:.|....:|.....|.:..
  Rat   491 RDCKTETSYLEMERRGKYSSKLERESKR--------------TSEHEAIKRCCSPPNELGFRRGS 541

  Fly  2434 QTMQATTTPTATYQTLQATNTDK----KIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVK 2494
            ...:.....|:.|::..:.:..|    |.....|...:..|...:.:.|....|..:|::.:::.
  Rat   542 SYSKHDNNSTSRYKSALSKSISKSDKFKNSFCCTELNEENKQSHSFSLQTPCSKGSELRTINKIP 606

  Fly  2495 PIQAKLQPHPQQHQQQQQT---QVQQPITVMGQNLLQPQLLFQSSTQTQAPQIILPQAQPQNIIS 2556
            ..:....|.|........|   ..:.||       |:|:.:...|.:: ..::.||:.:...:.:
  Rat   607 EREKTGSPSPSNQLNDSPTFKKLDESPI-------LKPEFIGHDSHES-IKELELPKMKNDQLRN 663

  Fly  2557 FVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSG 2621
            |.:           |.:...|  .|:.: |...||.|:.|.|            :.:|:..|.:|
  Rat   664 FCS-----------IELNVNG--SPETE-TDVATFRTSKPDA------------ISMTSDDSVTG 702

  Fly  2622 LQMLTAQSLQAQPQVIGTLIQPQTIQLGG-----GAD--------GNQPGSNQQPLILGGTGGGS 2673
            .::        .|.:.|.::.....|..|     .||        ...|....:||:
  Rat   703 SEV--------SPLIKGCVLSSNGFQSVGRCRERDADDACRQHNKSKSPFRETEPLL-------- 751

  Fly  2674 SGLEFATTSPQ----VILATQPMYYGLETIVQNTVMSSQQFVSTA-MPGMLSQNASFSATTTQVF 2733
                    ||.    :.|..:.:.|. :|:::..|........|. .....|.|.|..|...::
  Rat   752 --------SPHHDKVMSLPVKTIDYS-KTLIKEPVDKRHSCCKTKDSDRYCSPNESSEAENREI- 806

  Fly  2734 QASKIEPIVDLPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQ-SVPTSS 2797
                                     |:..|:|        ...|:.|.:..|.....| |..|..
  Rat   807 -------------------------SSNCFVN--------VHLDSKTVVCDNRELTDQHSEFTCD 838

  Fly  2798 GASTSMDYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQ 2862
            |...|:..||.          ..:...:...::.|.||:..:        :.||:.|..:::
  Rat   839 GYKQSIGSTSS----------ASLNHFDDLYESVGSSGISSL--------QSLPSGIRCEEN--- 882

  Fly  2863 VKNSNLKQSQVKGKAASGTGTTCGAPPSIASKP-------LQKKTNMIRPIHKLEVKPKVMKPTP 2920
                                 |..|..::.||.       :.|:|:::..:      |...|...
  Rat   883 ---------------------TSPALDTVQSKKGIDFLKYVGKETDVVSAL------PDSGKAFS 920

  Fly  2921 KVQNQNHSLLQQQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQP 2985
            ..:|: |::|..|..|:.|           :....|:.::|..::....:.:|....||....:
  Rat   921 SWENR-HNMLSGQSLQESQ-----------EEGSSTLHERRGRSEVSLDEEEQRGHTHISDDSE- 972

  Fly  2986 LQQQQVQVQPSMPIITLAEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCS------- 3043
                  .|.|....:|:.::..|......:... ...|:.:.|....::||:|||:.|
  Rat   973 ------VVFPYDLNLTMEDSDGVTYTLKCDSSG-NAPEIVSTVHGDYSASSASSSDESDSEDTES 1030

  Fly  3044 ---------------LPTNVVNPMQQQAP-STTSSSTTRP---------TNRVLPMQQRQEPAPL 3083
                           :|.|...||::.:| |:.||.:.|.         .:|....:::.| :..
  Rat  1031 DDSSIPRNRLQSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDGLESRRHAYEEKFE-SMA 1094

  Fly  3084 SNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELKVSSVLESIVPDVTMDA 3148
            |..|         ...|:..:|:.|..:....|:|              .|..:::.:|::   |
  Rat  1095 SKGC---------SQTEKFFLHKGTERNPETSYSQ--------------FSRKIDNHLPEI---A 1133

  Fly  3149 ILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEPMDTDV 3213
            ..:...|..:.:|:  .:.:|.|...:|..:..:..|                      |.:..|
  Rat  1134 HSQSDGVDSTSHTD--VKSDSVGHLNSEDAIRAKMSR----------------------PQELPV 1174

  Fly  3214 YRE--EDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVK--DKI--SKILDNLTNDDCADSIA 3272
            |.:  |||.....:...||.:..:|.....|:|.|....:.  |.:  |:.|.||..|.......
  Rat  1175 YCDDFEDLPNTSRQQMIFSNRPDSSRLGKAELSFSSSCDISRMDGLHSSEELRNLGWDFSQQERP 1239

  Fly  3273 TATTMEVDASAG------YQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMADAH-- 3329
            |.|..:.|:|.|      |||..|....|       .:.::|              |...|..
  Rat  1240 TTTYQQPDSSYGTCGTHKYQQSAEHYGGT-------HDYWQG--------------NGYWDPRSA 1283

  Fly  3330 --------VLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEPPQPIQEPKKMTG 3386
                    |.|  ::|..|...|...:||:....|.                           :|
  Rat  1284 GRPPGTGVVYD--RIQGQVPDSLTDDREEEENWDQR---------------------------SG 1319

  Fly  3387 PHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALK 3451
            .|  :...|...|.::.                                |.|.:|...:.:|::|
  Rat  1320 SH--FSSPSNKFFFHQK--------------------------------DKGSVQAPEISSNSIK 1350

  Fly  3452 --YLIEQLPGVEK-------CSKYTPKYHKRNGNVSTAANGAHGGNL-------GGSSASAALSV 3500
              .:|.:.....|       ..:..||..::.....:.::|......       .|.|:....|.
  Rat  1351 DSLVINERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGELQARKKVRVEIEQGQSSVPQHSE 1415

  Fly  3501 SGGDSHGLLDYGSDQ---------------DELEENAYDCARCEPYSNRSEYDM------FSWLA 3544
            ..|.|..:.|:...|               |.:|||.|   ..|...|:|..|:      .:.|:
  Rat  1416 LVGPSCAMDDFRDPQRWKEFAKLGKMPCYFDLIEENVY---LTERKKNKSHRDIKRMQCECTPLS 1477

  Fly  3545 SRHRKQPIQVFVQPSDNELV--------PRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRG 3601
            ...|.|......:...|.|:        |.....||      .|..::.:.| |.|..:...|.|
  Rat  1478 KDERAQGEVACGEDCLNRLLMIECSSRCPNGDYCSN------RRFQRKQHAD-VEVILTEKKGWG 1535

  Fly  3602 LYCTKDIEAGEMVIEYAGELIRSTLTDKRE------RYYDSRGIGCYMFKIDDNLVVDATMRGNA 3660
            |...||:.:...|:||.||::     |.:|      .|..::.|..|...:.::.::|||.:||.
  Rat  1536 LRAAKDLPSNTFVLEYCGEVL-----DHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNC 1595

  Fly  3661 ARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFP-FEDEKIPCSCGSKRCRKY 3724
            :||:||.|||||.::...:.|...:..|..:.:..|.|||:||:|. :..|...|.|||..||.|
  Rat  1596 SRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGY 1660

  Fly  3725 L 3725
            |
  Rat  1661 L 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787	356/2016 (18%)
		FYRC	3388..3476	CDD:197781	12/96 (13%)
		SET_KMT2A_2B	3575..3726	CDD:380947	51/158 (32%)
Setd2	NP_001388092.1	AWS	1467..1521	CDD:197795	9/59 (15%)
		SET_SETD2	1521..1662	CDD:380949	50/147 (34%)
		TCRP1	2136..>2319	CDD:434335
		WW	2362..2391	CDD:459800
		SRI	2438..2526	CDD:462404