Protein Alignment trx and Ash1l

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: XP_063137913.1
• Gene: Ash1l / 310638
• RGDID: 1306350
• Length: 3000
• Species: Rattus norvegicus
• Alignment Length: 2477
• Identity: 445/2477 - (17%)
• Similarity: 813/2477 - (32%)
• Gaps: 834/2477 - (33%)

  Fly  1853 SPSVTYESNFEVSRPVYVE--------LDRKRKKLIE--------PARVQFHI-------GSLEV 1894
            |||..........|.|.:|        ..|.|::.||        .|:.||.:       |:|::
  Rat    64 SPSAISSGTLASKREVEIEGNTDEEDPRKRNRERAIEAGKDDGLTDAQQQFSVKETNFSEGNLKL 128

  Fly  1895 RQLGAIVPRFSDSYEAVVPINFLCSRLYWSSKEPWKIVEY----TVRTTIQNSSSTL-------- 1947
            : :|....|                    :.|.|..:..|    .::||:::|...|
  Rat   129 K-IGLQAKR--------------------TKKPPKNLENYVCRPAIKTTVKHSRKALKSGKMTDE 172

  Fly  1948 ---------------------TALDVGRNYTV-----DHTNPNSKEVQLGMAQIARWHTSL---- 1982
                                 ||::.....:|     ...||.||::....:|:|.:..:.
  Rat   173 KNEHCPSKWDSSKLFKKAGDATAIECQSEESVHLHSQGENNPLSKKLSPVHSQMADYIPAAPPLV 237

  Fly  1983 ------ARSEFLENGGTDWSGEFPNPNSCVPPDENTEEEPQQ----------------------- 2018
                  .:...|.||||..:.:.....:..||.::::.:|::
  Rat   238 GSRDPDIKDRALLNGGTSVTEKLAQLIATCPPSKSSKAKPKKLGTGTTVGLVSKDLIRKPGVGSI 302

  Fly  2019 ----QADLL-PPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLF--AISEQSKD-------GTQ 2069
                ..||: .|.|..|:          |:...|    ..|..:|  |:|..:||       ||.
  Rat   303 AGIIHKDLIKKPALSTAV----------GLVTKD----PGKKPMFNAAVSLINKDSVKKLGTGTT 353

  Fly  2070 AMTSNQAQNQNQQAGGANSVSICDED--------------TRNSNTSLGNGWPASNPVEDAMLSA 2120
            |:..|  ::..::.|...:|.:..:|              .:.|...||.|.......::.   .
  Rat   354 AVFIN--KDLGKKPGTVTTVGLLSKDPGKKLGIGIVPGLVNKESGKKLGLGTVVGLVNKEL---G 413

  Fly  2121 ARNSSQVQMLKTLAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQ 2185
            .:.||.|.::......|:..:|||..      ::|::.:.:.....:.|...|:...:    :.:
  Rat   414 KKLSSTVGLVAKDVTKKIVASSAMGL------VNKDIGKKLLSCPIAGQLGSKDALNL----KSE 468

  Fly  2186 SISETSVEGVATTSGSVRS-------KSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSIT-- 2241
            ::..|..:..|:.|.::.:       :|...||..:.|||:..|.  :|..:::...|...||
  Rat   469 ALLPTQEQLKASCSANISNHESQELPESLKDSATSKTFEKNVMRH--SKESMLEKFSVRKEITNL 531

  Fly  2242 ------EFRIISGD-------GNLSTAQFSGQVKCDRCQCTYRNY------DAF----------Q 2277
                  |...|..|       |...|::...|   ....||..::      ||.          :
  Rat   532 EKEMFNEGTCIQQDSFSSNERGAFETSKHEKQ---PPVYCTSPDFQIGGASDASTAKSPFGAVGE 593

  Fly  2278 RHLPSCSPTMSSN-------ETESDVSGQGMTNNATQISAESLNELQKQLLANAGGLNYLQSATS 2335
            .:|||.|||:|.|       ||.|.:....:..|:|   ||.:.|:.:.:     |.|...:.::
  Rat   594 SNLPSSSPTVSVNPLTRNPPETSSQLVPNPLLLNST---AEQMEEISESI-----GKNQFTAEST 650

  Fly  2336 FPQV--QSLGSLGQFGLQGLQQ-----------LQLQPQSLGSGFFLSQPNPATQANTDDLQIYA 2387
            ...|  :|||.......:|:.:           :.....|||     .:|:.|:.:....:....
  Rat   651 HLNVGHRSLGHSISIECKGIDKELNESKSTHLDISRISSSLG-----KKPSLASDSGIHTITPSV 710

  Fly  2388 NSLQSLAAN-----LGGGFTLAQPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQ 2447
            .:..||.:|     ||        .|.||.:...:|.|.:.....:.::..:..:|..|......
  Rat   711 VNFTSLFSNKPFLKLG--------AVAAPDKHCQVAESLSTSFQSKPLKKRKGRKARWTKVVARS 767

  Fly  2448 T--------LQATNTDKKIML-PLTAAGKPLKTVATKAAQQAA----VKQRQLKSGHQVKPIQAK 2499
            |        |:.:...|.:.. .|:.:.:|.|.:.|..|....    :|:|..|......|..|.
  Rat   768 TCRSPKGLDLERSELFKNVSCSSLSNSSEPAKFMKTIGASSFVDHDFLKRRLPKLSKSSAPSLAL 832

  Fly  2500 L-------------------------------QPHPQQHQQQQQTQVQQP----ITVMGQNLLQP 2529
            |                               :|...:.:.::..|::.|    :.:....:...
  Rat   833 LADSEKASHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFSL 897

  Fly  2530 QLLFQSSTQTQAPQIILPQAQPQNI---ISFVTGDGSQGQPLQYISIPTAGEYKPQPQPTATPTF 2591
            |     |.:.|.|.|:.|:.:..:.   :|.......:|:|.:.:..|.  :.|| |..:..|..
  Rat   898 Q-----SKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRSPV--KMKP-PVLSVAPFV 954

  Fly  2592 LTTAPG----------AGATYLQTDASGNLVLTTTPSNSGLQMLTAQS-LQAQP----------Q 2635
            .|.:|.          :.:.:.:::  ..|..|....:|..|.:.:.| |:.:|          |
  Rat   955 ATESPSKLESESENHRSSSDFFESE--DQLQDTDDLEDSHRQSVCSVSDLEMEPDKKISKRNNGQ 1017

  Fly  2636 VIGTLIQP----QTIQ--------LGGGADGNQPGSNQQPL-----ILGGTGGGSSGLEFATTSP 2683
            ::.|:|:.    :|::        |....:.:..|..|..|     .|..|.|...|.:...:..
  Rat  1018 LMKTIIRKINKMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATFGSKLGQQINVSKK 1082

  Fly  2684 QVILATQPMYYGL------ETIVQNTVMSS-----------QQFVSTA----MPGMLSQNASF-- 2725
            ..|      |.|.      :|::...:..|           ||...:|    :|.:|...||.
  Rat  1083 GTI------YIGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSPASSSE 1141

  Fly  2726 ---SATTTQVFQASKIEPIVDLPAGYV---------VLNNTGD---------------ASSAGTF 2763
               |...:|....|..:..|...||:|         |.:..|.               ..|..|.
  Rat  1142 ILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVPYLHVHSRQGSMIQTLAMKKAAKGRRRLSPPTL 1206

  Fly  2764 L-NAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSMDYTS--------------PVMVTA 2813
            | |:.|.|.:.|.....|....:.:...:::|:.||..|..:.||              .....:
  Rat  1207 LPNSPSHLSELTSLKEATPSPVSESHSDETIPSDSGIGTDNNSTSDRAEKFCGQKKRRHSFEHIS 1271

  Fly  2814 KIPPVT--------------------------QIKRTNAQAKAAGISGVGKVPPQPQVVNKVLP- 2851
            .|||.|                          ::||...:.|          ...||:.|:..|
  Rat  1272 LIPPETSTVLNSLKEKHKHKCKRRSHDYLSYDKMKRQKRKRK----------KKYPQLRNRQDPD 1326

  Fly  2852 -----TSIVTQQSQVQVKNSN---------------------------------LKQSQVKGKAA 2878
                 ..::::.|::::.:.:                                 :::..:|.|.
  Rat  1327 FIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSFYTHPSFPLDPLHYIRKPDLKKKR- 1390

  Fly  2879 SGTGTTCGAPP----SIASKPLQKKTNM------IRPIHKLEVKPKVMK---------------- 2917
                   |.||    ::|..|.....:.      ..|.:.:...|..:.
  Rat  1391 -------GRPPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSPSPLTAAPIGLGYYGRYPPTL 1448

  Fly  2918 -------------PTPKVQNQNHSLLQ--QQQQQQPQLQQQIPAVVVNQVPKVTIS-QQRIPAQT 2966
                         |.|...:..|.||.  :..:::.:|.:|...:..::.|.:::| ...:|
  Rat  1449 YPPPPSPSFTTPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQEAFLTTSRTPLLSMSTYPSVP--- 1510

  Fly  2967 QQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITLAEAPVVQS----QFVME------------ 3015
              .::....|:....:.:...::....||.:.:.|.:...|::|    :|..:
  Rat  1511 --PEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDTGSSRSVLESLKRYRFGKDTVGDRYKHKEKH 1573

  Fly  3016 ------PQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQ----QQAPS------------ 3058
                  |.....:.|.||.:.:.:...|.||  ||...:..|:|    :.:||
  Rat  1574 RCHMSCPHLSPSKSLINREEQWVSREPSESS--SLALGLQTPLQIDCSESSPSLSLGGFTPNSEP 1636

  Fly  3059 ----------TTSSSTTRPTN-------------RVLPMQ-------QRQEPAPLSNECPVVSSP 3093
                      |::..:.|.:|             .:.|:|       .|:||.| |.|..:.|..
  Rat  1637 ASSDEHMNLFTSAIGSCRVSNPNSSCRKKLTDSPGLFPVQDTALSRPHRKEPLP-STERAIQSLA 1700

  Fly  3094 TPPKPVEQPIIHQMTSASVS---KCYAQKST------LP--SPVYEAEL--KVSSVLESIVPDVT 3145
            ......::|......|.:.|   |..:.:||      :|  ||...|.|  .|..:|:.||....
  Rat  1701 GSQSASDKPSQRSSESTNCSPTRKRSSSESTSSTVNGIPSRSPRLVASLDDSVDCLLQRIVQHDE 1765

  Fly  3146 MDAILE--EQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNNGYLLDKHTFQVEP 3208
            .:::.:  :.|:|    |......:|||.|.:::..|.:..                  :..|..
  Rat  1766 QESVEKNGDAPIT----TVSAPPSSSPGHSYSKERTLGKSD------------------SLLVPA 1808

  Fly  3209 MDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSEEPAVKDK------ISKILDNLTNDDC 3267
            :.:|......|..|         |:| |.|:.|.:..|...|::.:      ..|||....|.|.
  Rat  1809 VPSDSCNSIPLLSE---------KLA-SRCSPHHIKRSVVEAMQRQARKMCNYDKILATKKNLDH 1863

  Fly  3268 ADSIATATTMEVDASAGYQ--------------QMVEDVLATTAAQSAPTEEFEGA--------- 3309
            .:.|..|..::..|..|..              |.|..:.|..|||....|..||.
  Rat  1864 VNKILKAKKLQRQARTGNNFVKRRPGRPRKCPLQAVVSMQAFQAAQFVNPELNEGEEVSLHLSPD 1928

  Fly  3310 LETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRKEEQRTVSQEQEQSKAAIVPTAAAPEP 3374
            ..|..:||....:| :...|....|: :|.:..|..|:|::.....:|||.:|:.|....   |.
  Rat  1929 TVTDVIEAVVQSVN-LNSEHKKGWKR-KNWLLEEQTRKKQKTVPEEEEQENNKSFIEKPV---EI 1988

  Fly  3375 PQPIQEPKKMTGPHLLYEIQSEDGFTYKSSSITEIWEKVFEAVQVARRAHGLTPLPEGPLADMGG 3439
            |.|::.|.:.:.|               .|::    :.|...:...::|    |.|........|
  Rat  1989 PSPLETPAEPSEP---------------ESNL----QPVLALIPREKKA----PRPPKKKYQRAG 2030

  Fly  3440 IQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRNGNVSTAANGAHGGNLGGSSASAALSVSGGD 3504
            :.....||...|..:.||. .||. :|||..|
  Rat  2031 LYSDVYKTTDPKSRLIQLK-KEKL-EYTPGEH--------------------------------- 2060

  Fly  3505 SHGLLDYGSDQDELEENAYDCARCEPYSNRSEYD-MFSWLASRHRKQP-----------IQVFVQ 3557
                 :||.....:....|  .|.:....:..|| ::.|..::..|:|           :.|.|:
  Rat  2061 -----EYGLFPAPIHVGKY--LRQKRIDFQLPYDILWQWKHNQLYKKPDVPLYKKIRSNVYVDVK 2118

  Fly  3558 P-------------SDNELVPRRGTGSNLPMAMKY-----------------RTLKETYKDYVGV 3592
            |             .|::  .|:|.|.:....|.:                 |..:..:...:..
  Rat  2119 PLSGYEATTCNCKKPDDD--TRKGCGDDCLNRMIFAECSPNTCPCGEQCCNQRIQRHEWVQCLER 2181

  Fly  3593 FRSHIHGRGLYCTKDIEAGEMVIEYAGELI-----RSTLTDKRERYYDSRGIGCYMFKIDDNLVV 3652
            ||:...|.|:...:.::||:.:|||.||::     |:.:.::...:.|.     |...:|..:|:
  Rat  2182 FRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-----YCLNLDSGMVI 2241

  Fly  3653 DATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKF-PFEDEKIP-CS 3715
            |:...||.||||||.|:|||..:...:.|...|.::||:.:..|.||||||.| .|..||.. |.
  Rat  2242 DSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDVPAGTELTYDYNFHSFNVEKQQLCK 2306

  Fly  3716 CGSKRCR 3722
            ||.::||
  Rat  2307 CGFEKCR 2313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787	7/50 (14%)
		FYRC	3388..3476	CDD:197781	17/87 (20%)
		SET_KMT2A_2B	3575..3726	CDD:380947	51/172 (30%)
Ash1l	XP_063137913.1	None