Protein Alignment trx and G9a

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001259088.1
• Gene: G9a / 30971
• FlyBaseID: FBgn0040372
• Length: 1657
• Species: Drosophila melanogaster
• Alignment Length: 1947
• Identity: 329/1947 - (16%)
• Similarity: 598/1947 - (30%)
• Gaps: 646/1947 - (33%)

  Fly  2087 NSVSICDEDTRNSN--TSLGNGWPASNPVEDAMLSAARNSSQVQMLKTLAWPKLDGNSAMATAIK 2149
            ||:|    .|.||:  ||...|....|      |:.|.:       |||.|
  Fly     9 NSMS----STFNSDCATSTAEGGTLLN------LNLAED-------KTLKW-------------- 42

  Fly  2150 RRKLSKNLAEGVFLTLSSQQRNKKEMATVAGVSRRQSISETSVEGVATTSGSVRSKSFTWSAAKR 2214
                 :|||...|.:...:.::|:|      ..|:::.::..:|.:......|...    :|.|.
  Fly    43 -----RNLANNQFASKEKKHKDKEE------EERKEARNQEEIEDIKALLADVVDA----AAVKL 92

  Fly  2215 YFEKSEGREEA---AKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQVKCDRCQCTYRNYDAF 2276
            ..|:::..|:.   .|..| :.:|..:...:..:...|..:...| :|  |.........:.:..
  Fly    93 EEEEAQNAEKVEPHTKCEI-EEEGRKEMEYDQDVAKQDSEMEKKQ-NG--KATSITVKMESNERA 153

  Fly  2277 QRHLPSCSPTMSSNETESDVSGQGMTNNATQISAESLNELQKQLLANAGGL--NYLQSATSFPQV 2339
            ::|....:.|.:..........:.....|.:...|.:....::|.|||..|  ..::.|.:.|.|
  Fly   154 EKHATEIATTSTERWENESFKTEQQNKKAAEKEEEPILAATQKLEANAEPLTTTRIEVAVASPLV 218

  Fly  2340 QSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYANSLQSLAANLGGGFTLA 2404
            .|..|:                           ..|..|..          |..||...|..|||
  Fly   219 VSSASV---------------------------KLAADATN----------QMRAATSAGAATLA 246

  Fly  2405 QPTVTAPAQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTATYQTLQATNTDKKIMLPLTAAGKPL 2469
            ...           |..:|.||::..:.|:.:.   |||:.        ||:.:.:.....||..
  Fly   247 DKN-----------VQVSPGGTRRSRRTPRPID---TPTSV--------TDEHVQVENKKFGKSE 289

  Fly  2470 KTVATKA-------AQQAAVKQRQLKSGHQVKPIQAKLQPH------PQQHQQQQQTQVQQPITV 2521
            :.....:       ....|:.:.|||| ...||....|.|.      |::.:.:.: :::....|
  Fly   290 QYTDCSSHLERFTLDDNTAIVRLQLKS-EPDKPSLTALSPEENSAPAPKRGRGRAR-KIRPDAEV 352

  Fly  2522 MGQNLLQP--------------QLLFQSSTQTQAPQIILPQAQPQNIISFVTGD----------- 2561
            ....::.|              :|..:...|.|...:::.:.:.:.:.....||
  Fly   353 ETSEVILPCEDSLGEKKPGRKRKLPDEPIDQQQLSDLVVVKTEQEELGDAPLGDVKRMRRSVRLG 417

  Fly  2562 ---GSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDASGNLVLTTTPSNSGLQ 2623
               .:.|.|.:.:.....     .|||:|..:|...                        .|.:.
  Fly   418 NRLHADGSPWEEVKTEAL-----HPQPSAELSFAEV------------------------TSEIL 453

  Fly  2624 MLTAQSLQAQPQVIGTLIQPQTIQLGGGADGNQPGSNQQPLILGGTGGGSSG---LEFATTSPQV 2685
            .|.....:..|:..|...:...::|........|.:|      |.....|||   |:....|.:.
  Fly   454 PLAVLDEKTPPKKRGRKAKTPCVKLESETSCGLPFAN------GNKKTNSSGGCELQLPKRSKRR 512

  Fly  2686 ILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASKIEPIVDLPAGYVV 2750
            |..|       ..|::|..:..:                        |:...||.:....:...|
  Fly   513 IKPT-------PKILENDELRCE------------------------FETKHIERMTQWESAAAV 546

  Fly  2751 LNNTGDASSAGTFLNAASVLQQQTQDDTTTQILQNANFQFQSVPTSSGASTSM------------ 2803
            ..:....::.|...|:::..|:..:.|.:         .|:..|.....::::
  Fly   547 DGDFETPTTGGNGSNSSTSRQKSDKSDGS---------NFEGGPGHPAGTSAIKKRLFSKSQRDI 602

  Fly  2804 -DYTSPVMVTAKIPPVTQIKRTNAQAKAAGISGVGKVPPQPQVVNKVLPTSIVTQQSQVQVKNSN 2867
             :|.:.::..:|:||...:::.....||:.|:  ....|:.:.:||.....: .:|.:..:|:..
  Fly   603 ENYGAAMLAKSKLPPCPDVEQFLNDIKASRIN--ANRSPEERKLNKKQQRKL-AKQKEKHLKHLG 664

  Fly  2868 LKQSQVKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEV-KPKVMKPTPKVQNQNHSLLQ 2931
            |:::.....:.:.:..|               .|...|..:::| ||.|   |.:|:|   |:.:
  Fly   665 LQKNHRDEPSDNDSSNT---------------DNEFFPTTRVQVGKPSV---TLRVRN---SVTK 708

  Fly  2932 QQQQQQPQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQM---IHIPQQQQPLQQQQVQV 2993
            :.........::.|.|   |..|:|   :||.|:...:..:.|:.   |..|..:| |......:
  Fly   709 ELPTTATLKSRRNPVV---QAAKLT---RRIGARAAGEVTEAARASVPISTPDAEQ-LHSLDTSI 766

  Fly  2994 QPSM-PIITLAEAPVVQ--SQFV---MEPQALEQQELANRVQHFSTSSSSSSSNCSL------PT 3046
            |..: ||..|...|...  |:|:   .:|.           |:::.::..||..|::      ..
  Fly   767 QADVTPIRDLDMRPSTSRVSKFICLCQKPS-----------QYYARNAPDSSYCCAIDHIDDQKI 820

  Fly  3047 NVVNPMQQQAPSTTSSSTTRPTNR--------------------------------VLPMQQR-- 3077
            ...|.:     |:...:..||:.|                                ||..||.
  Fly   821 GCCNEL-----SSEVHNLLRPSQRVSYMILCDEHKKRLQSHNCCAGCGIFCTQGKFVLCKQQHFF 880

  Fly  3078 --------------------QEPAPLSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTL 3122
                                :|...:....||:....|...::.|   :.||....||    .:|
  Fly   881 HPDCAQRFILSTSYEKELGDEEDQGVKFSSPVLVLKCPHCGLDTP---ERTSTVTMKC----QSL 938

  Fly  3123 PSPVYEAELKVSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQL--------- 3178
            |..:...:.|:...      .:|..:.|.:....|:..|.|...:|..|.|....|
  Fly   939 PVFLRTQKYKIKPA------RLTTSSHLTQFGTVENANTPGATARNKGGLSTAVTLSAASSPASK 997

  Fly  3179 ----------LLQQQQREQLNQ----QLVNNGYL---LDKHTFQVEPMDTDVYREEDLEEEEDED 3226
                      ......|..||.    ||:....:   |..|........|..:...|:......|
  Fly   998 TNGAQRGRAGTSNSNSRHALNSINFAQLIPESVMNVVLRGHVVSASGRVTAEFTPRDMYYAVQND 1062

  Fly  3227 DDFSLKMATSACNDHEMSDSEEPAVKDKISKILDNLTNDDCAD-SIAT-------ATTMEVDASA 3283
            |                        .:::::||       .|| ::.|       .|.:.:.|.:
  Fly  1063 D------------------------LERVAEIL-------AADFNVLTPIREYLNGTCLHLVAHS 1096

  Fly  3284 GYQQMVEDVLATTAAQSAPTEEFEGALETAAVEAAATYINEMADAHVLDLKQLQNGVELELRRRK 3348
            |..||...:|...|:........:..|.||.:.|.   :||..|  :|:| .||.|.::
  Fly  1097 GTLQMAYLLLCKGASSPDFVNIVDYELRTALMCAV---MNEKCD--MLNL-FLQCGADV------ 1149

  Fly  3349 EEQRTVSQEQEQSKAAIVPTAAAPEPPQPI----QEPKKMTGPHLLYEIQSEDGFTYKSSSITEI 3409
                .:.....::...|.......|..|.|    :..:.:|......:.|.|.|:|      ..:
  Fly  1150 ----AIKGPDGKTSLHIAAQLGNLEATQLIVDSYRTSRNITSFLSFIDAQDEGGWT------AMV 1204

  Fly  3410 WEKVFEAVQVARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYLIEQLPGVEKCSKYTPKYHKRN 3474
            |........:.|    |..||:.....:..|.:.      :.:|:.|......|.       ..|
  Fly  1205 WAAELGHTDIVR----LASLPQAVFLKLINIFLF------ISFLLNQDADPNICD-------NDN 1252

  Fly  3475 GNV---STAANGAHGGNLGGSSASAALSVSGGDSH-----------------------GLLDYGS 3513
            ..|   ||..|       .|......|..||.|.:                       .|:..|:
  Fly  1253 NTVLHWSTLHN-------DGLDTITVLLQSGADCNVQNVEGDTPLHIACRHSVTRMCIALIANGA 1310

  Fly  3514 D---QDELEENAYDC-----ARC-------------EPYSNRSEYDMFSWLASRHRKQPIQVF-- 3555
            |   :::.|:..:||     :.|             .|...|: :.:.:..::....:||||.
  Fly  1311 DLMIKNKAEQLPFDCIPNEESECGRTVGFNMQMRSFRPLGLRT-FVVCADASNGREARPIQVVRN 1374

  Fly  3556 -VQPSDNE------------------------LVPRR----------------------GTGSNL 3573
             :..|:||                        .:.||                      .:..|.
  Fly  1375 ELAMSENEDEADSLMWPDFRYVTQCIIQQNSVQIDRRVSQMRICSCLDSCSSDRCQCNGASSQNW 1439

  Fly  3574 PMAMKYRTLKETYKDYVGVF-------------------------------RSHIHGRGLYCTKD 3607
            ..|.........|:|...:|                               .....|.|:....:
  Fly  1440 YTAESRLNADFNYEDPAVIFECNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALAN 1504

  Fly  3608 IEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNC 3672
            :..|..|..|.||::.:...|:|..  ||     |.|.:|:...:||...||..||.||.||||
  Fly  1505 VPKGTFVGSYTGEILTAMEADRRTD--DS-----YYFDLDNGHCIDANYYGNVTRFFNHSCEPN- 1561

  Fly  3673 YSKVVDI-LGHKH-------IIIFALRRIVQGEELTYDY--KFPFEDEK--IPCSCGSKRCR 3722
               |:.: :.::|       |..|:.|.|..|||:.:||  ||...:.:  :.|.|.:..|:
  Fly  1562 ---VLPVRVFYEHQDYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSCVGCRCLTTTCK 1620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1890..1937	CDD:461787
		FYRC	3388..3476	CDD:197781	14/87 (16%)
		SET_KMT2A_2B	3575..3726	CDD:380947	46/191 (24%)
G9a	NP_001259088.1	PTZ00121	<68..>188	CDD:173412	16/127 (13%)
		EHMT_ZBD	786..933	CDD:411018	23/165 (14%)
		ANKYR	1063..1322	CDD:440430	57/335 (17%)
		ANK repeat	1088..1120	CDD:293786	7/31 (23%)
		ANK repeat	1124..1153	CDD:293786	11/44 (25%)
		ANK repeat	1155..1196	CDD:293786	5/40 (13%)
		ANK repeat	1199..1249	CDD:293786	10/65 (15%)
		ANK repeat	1251..1283	CDD:293786	10/38 (26%)
		ANK repeat	1285..1316	CDD:293786	3/30 (10%)
		SET_EHMT	1391..1622	CDD:380941	49/241 (20%)