Protein Alignment trx and Nsd1

DIOPT Version :10

• Sequence 1: NP_476769.1
• Gene: trx / 41737
• FlyBaseID: FBgn0003862
• Length: 3726
• Species: Drosophila melanogaster
• Sequence 2: NP_001388465.1
• Gene: Nsd1 / 306764
• RGDID: 1307748
• Length: 2689
• Species: Rattus norvegicus
• Alignment Length: 2489
• Identity: 453/2489 - (18%)
• Similarity: 757/2489 - (30%)
• Gaps: 931/2489 - (37%)

  Fly  1633 MSQVIQQSNCDELDIAYKELLSEQFPWFQNETKACTDALE-----------------EDMFE--- 1677
            |:|....:|..||.::..:.....|..|.|.|  |.|..:                 |::||
  Rat   126 MNQEPTCNNPPELQLSVTKTTKNGFLHFDNFT--CVDDADVDSEMDPEQPVTEDESIEEIFEETQ 188

  Fly  1678 ---SCSGGNYEDLQDTGGVSASVYNEHSTSQAESRSGVLD---IPLEEVDDFGSCGIKMRLDTRM 1736
               ||   |||. :...||..::.:|.. |..|||.|.::   :||....:      |.:...|
  Rat   189 TNASC---NYEP-KSENGVEMAMGSEQD-SMPESRHGAVEQPFVPLAPQTE------KQKNKQR- 241

  Fly  1737 CLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCG 1801
                                                   .|:|||.:......|...:      |
  Rat   242 ---------------------------------------SEVDGSNEKTALLPAPNSL------G 261

  Fly  1802 NRGATVGCNVRSCGEHYHYPCARSIDCAFLTDKSMYCPAHAKNGNALKANG--SPSVTYESNFEV 1864
            :...|:       .|.::     ||:.:|..|..   .:.:..||.|:..|  |||.:.|..|
  Rat   262 DTNVTI-------EEQFN-----SINLSFQDDPD---SSTSTLGNMLELPGTSSPSTSQELPF-- 309

  Fly  1865 SRPVYVELDRKRKKLIEPARVQFHIGSLEVRQLGAIVPRF-----------SDSYEAVVPINFLC 1918
            ..|         ||...|  :::.:|.|       |..:|           ||      |:....
  Rat   310 CHP---------KKKSTP--LKYEVGDL-------IWAKFKRRPWWPCRICSD------PLINTH 350

  Fly  1919 SRLYWSSKEPWKIVEYTVRTTIQNSSSTLTA-----LDVGRNY--TVDHTNPNSKEVQLGMAQ-- 1974
            |::..:::.|::  ||.|......|.....|     :..||:.  .:.......|:.:.|...
  Rat   351 SKMKVANRRPYR--EYYVEAFGDPSEKAWVAGKAIVMFEGRHQFEELPVLRKRGKQKEKGYRHKV 413

  Fly  1975 ----IARWHTSLARSEFLE--NGGTDWSGEFPNPNSCVP-----------PDENTEEEPQQQADL 2022
                :::|..|:..:|..:  .|        |....|||           |.|:...:|..:.||
  Rat   414 PQKILSKWEASVGLAEQCDVPRG--------PKTQKCVPSSAKLDSEEDMPFEDCANDPDSEHDL 470

  Fly  2023 LPPELKDAIFEDLPHELLDGISMLDIFLYDDKTDLFAISEQSKDGTQAMTSN--------QAQNQ 2079
            |......::..|..|..            |:|....|.|...|.......::        :||.:
  Rat   471 LLNGCLKSLAFDSEHSA------------DEKEKPCAKSRVRKSSDNIKRTSVKKGLMPFEAQKE 523

  Fly  2080 NQQ------------AGGANSVSICDEDTRNSNTSLGNGWPASNPVEDAMLSAARNSSQVQMLKT 2132
            .::            :||.:.....:|.:|.:|:..|:   ::.|.:....|..:|:::.. .:|
  Rat   524 ERRGKSPENLGLDFLSGGVSDKQASNELSRIANSLTGS---SAAPGQFLFSSCGQNTAKTD-FET 584

  Fly  2133 LAWPKLDGNSAMATAIKRRKLSKNLAEGVFLTLSSQQRNKKEMATV-AGVSRRQSISETSVEGVA 2196
            .....|.|.|..|...|.....|.|..|...:      :|.::..| ||...::|.|.:    |.
  Rat   585 PNCDSLSGLSESALISKHSGEKKKLQPGQVCS------SKVQLCYVGAGDEEKRSDSVS----VC 639

  Fly  2197 TTSGSVRSKSFTWSAAKRYFEKSEGREEAAKMRIMQMDGVDDSITEFRIISGDGNLSTAQFSGQV 2261
            |||                                     ||         |..:|...:.:.:.
  Rat   640 TTS-------------------------------------DD---------GSSDLDPTEHNSEF 658

  Fly  2262 KCDRCQCTYRNYDAFQRHLPSCSPTMSSNETESDVSGQGMTNNATQIS----AESLNELQKQLLA 2322
                             |......|.:.::||:.:|   |..|.|:.|    ...:.|.||.|:.
  Rat   659 -----------------HKSVLEVTDALDKTENALS---MHKNETKYSRYPATNRVKEKQKSLIT 703

  Fly  2323 NAGGLNYLQSATSFPQVQSLGSLGQFGLQGLQQLQLQPQSLGSGFFLSQPNPATQANTDDLQIYA 2387
            |: ..::|..:|...:.         |...:.|:.|....:.|..    |.|..:...|.|....
  Rat   704 NS-HTDHLMDSTKTVEP---------GTAEISQVNLSDLKISSPI----PKPQPEFRNDGLTTKF 754

  Fly  2388 NSLQSL----AANLGGGFTLAQPTVTAP---AQPQLIAVSTNPDGTQQFIQIPQTMQATTTPTAT 2445
            |:...:    :...||   ||..|: .|   .||:..::..      :..:.|..  |.|:.|:.
  Rat   755 NAPPGIRNENSLTKGG---LANQTL-LPLKCRQPKFRSIKC------KHKESPTA--AETSATSE 807

  Fly  2446 YQTLQATNTDKKIMLPLTAAGKPLKTVATKAAQQAAVKQRQLKSGHQVKPIQAKLQPHPQQH--- 2507
            ..:|:..::|..        |.|:.:: :|:.:...:|  .|.:.|:.....:.::....:|
  Rat   808 DLSLKCCSSDTN--------GSPMTSI-SKSGKGEGLK--LLNNMHEKTRDSSDIETAVVKHVLS 861

  Fly  2508 --QQQQQTQVQQPITVMGQNLLQPQLLFQS-STQTQAPQIILPQAQ------------------- 2550
              ::.....:.:.::..|.:.....|||.| |:|...|  |.|..:
  Rat   862 ELKELSYRSLSEDVSDSGTSKSSKPLLFSSASSQNHIP--IEPDYKFSTLLMMLKDMHDSKTKEQ 924

  Fly  2551 ----PQNIISFVT---GDGSQGQPLQYISIPTAGEYKPQPQPTATPTFLTTAPGAGATYLQTDAS 2608
                .||:.|:.|   ||.|.|.|
  Rat   925 RLMTAQNVASYRTPDRGDCSSGSP----------------------------------------- 948

  Fly  2609 GNLVLTTTPSNSGLQMLTAQSLQAQPQVIGTLIQPQTIQLGGGA-DGNQPGSNQQPLILGGTGGG 2672
                                        :||   .:.:.|||.. :..:||.:.|..:....|||
  Rat   949 ----------------------------VGT---SKVLVLGGSTHNSEKPGDSTQDSVRLSPGGG 982

  Fly  2673 SSGLEFATTSPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGMLSQNASFSATTTQVFQASK 2737
            .|.|....:|...:|.:.          :..:.:..:..|..:|......|..|...........
  Rat   983 DSALSGELSSSLSVLPSD----------KRDLPACGKIRSNCIPRRNCGRAKLSPKLRVTISTQM 1037

  Fly  2738 IEPIVD--------------LPAGYVVLNNTGDASSAGTFLNAASVLQQQTQDDTTTQ------I 2782
            .:|.|:              |||..:..|..|:..|.|: :|..  |:...||....:      :
  Rat  1038 AKPSVNPKALKTERKRKLSRLPAVTLAANGLGNKESGGS-VNGP--LKGGAQDPAKEEPLQQMDL 1099

  Fly  2783 LQNANFQFQSVPTSS--------------------GASTSMDYTSPVMVTAKIP----------- 2816
            |:|....|.|....|                    |:..:::...|..|...:|
  Rat  1100 LRNEETHFDSKVKQSDPDKILEKEPSFENRKGPEVGSEINIENDEPHGVDQVVPKKRWQRLNQRR 1164

  Fly  2817 --PVTQIKRTNAQAKAAGISGVGKVPPQP-------QVVNKVLPTSIVTQQSQVQVKNSNLKQSQ 2872
              |..:..|...:..:.|..|| .:|..|       .:..:..||||        :::|....:.
  Rat  1165 PKPGKRASRFREKENSEGAFGV-LLPGDPVQKGRDDYLEQRAPPTSI--------LEDSAADPNH 1220

  Fly  2873 VKGKAASGTGTTCGAPPSIASKPLQKKTNMIRPIHKLEVKPKVMKPTPKVQNQNHSLLQQQQQQQ 2937
            |....:.|.........|::...|:|:|.:  |    .:.|:...|.|.|:::...|
  Rat  1221 VSHSESVGPRLNVCDKSSVSMGDLEKETGI--P----SLTPQTKIPEPAVRSEKKRL-------- 1271

  Fly  2938 PQLQQQIPAVVVNQVPKVTISQQRIPAQTQQQQLQQAQMIHIPQQQQPLQQQQVQVQPSMPIITL 3002
                                   |.|::...:..::...|..|:::|...|:||....|
  Rat  1272 -----------------------RKPSKWLLEYTEEYDQIFAPKKKQKKVQEQVHKVSS------ 1307

  Fly  3003 AEAPVVQSQFVMEPQALEQQELANRVQHFSTSSSSSSSNCSLPTNVVNPMQQQAPSTTSSSTTRP 3067
                           ..|.:.|..|.:       ||:.|            :|....:..||
  Rat  1308 ---------------RCEDESLLARCR-------SSAQN------------KQVDENSLIST--- 1335

  Fly  3068 TNRVLPMQQRQEPAPLSNECPVVSSPTPPKPVEQPIIHQMTSASVSKCYAQKSTLPSPVYEAELK 3132
                     ::||..|..|.|.         :|.|::              :|.|  .|..|||.
  Rat  1336 ---------KEEPPVLEREAPF---------LEGPLV--------------QSDL--GVAHAELP 1366

  Fly  3133 VSSVLESIVPDVTMDAILEEQPVTESIYTEGLYEKNSPGESKTEQLLLQQQQREQLNQQLVNN-- 3195
            ..::...:.|:|:....||.:.:.  :.|.|.||              .::||:...:.|.:|
  Rat  1367 QLTLSVPVAPEVSPRPTLESEELL--VKTPGNYE--------------GKRQRKPTKKLLESNDL 1415

  Fly  3196 --GYLLDKHTFQVEPMDTDVYREEDLEEEEDEDDDFSLKMATSACNDHEMSDSE-EPAVKD---K 3254
              |::..|                       .|...|.|...|...::.:.||. .|.:|:   .
  Rat  1416 DPGFMPKK-----------------------GDLGLSRKCCESGHLENGVGDSRATPHLKEFGGG 1457

  Fly  3255 ISKILD------------------NLTNDDCADSIATATTMEVDASAGYQQMVEDVLATTAAQSA 3301
            .::|.|                  .:..:|.|        .|..:||..:.|:.    .|||  :
  Rat  1458 TTRIFDKPRKRKRQRHGTARVHYKRVKKEDSA--------RETPSSAEGELMIH----RTAA--S 1508

  Fly  3302 PTEEFEGALE-TAAVEAAATYINEMADAHVLDLKQLQNGVEL----------------------E 3343
            |.|..|..:| ...:.|:.....|......|.....||..:|                      |
  Rat  1509 PKEILEEGIEHDPGMSASKRLQGERGGGAALKENVCQNCEKLGELLLCEAQCCGAFHLECLGLTE 1573

  Fly  3344 LRRRK---EEQRT-------VSQEQEQSKAAIVP--------TAAAPEPPQPIQEPKKMTGPHLL 3390
            :.|.|   .|.||       ..|..|..|..::|        ......||..:|........|:.
  Rat  1574 MPRGKFICNECRTGIHTCFVCKQSGEDVKRCLLPLCGKFYHEECVQKYPPTVVQNKGFRCPLHIC 1638

  Fly  3391 YEIQSEDGFTYKSSSITEIWEKVFEAVQ--VARRAHGLTPLPEGPLADMGGIQMIGLKTNALKYL 3453
            ....:.:.....:|.     .::...|:  ||..|:...      ||       .|.|..|...:
  Rat  1639 ITCHAANPANVSASK-----GRLMRCVRCPVAYHANDFC------LA-------AGSKILASNSI 1685

  Fly  3454 IEQLPGVEKC-SKYTPKYHKRNG---NVSTAANGAHGGN-LGGSSASAA-----LSV-------- 3500
            |        | :.:||:...||.   |||.....:.||: |...|..||     |::
  Rat  1686 I--------CPNHFTPRRGCRNHEHVNVSWCFVCSEGGSLLCCDSCPAAFHRECLNIDIPEGNWY 1742

  Fly  3501 -----SGGDSH--------------------------------------------GLLDY----- 3511
                 :|...|                                            |..||
  Rat  1743 CNDCKAGKKPHYREIVWVKVGRYRWWPAEICHPRAVPSNIDKMRHDVGEFPVLFFGSNDYLWTHQ 1807

  Fly  3512 ----------------------GSDQDELEENAYDCARCEPYSNRSEYDMFSWLASRHRKQP--- 3551
                                  |:.:..|:|.|   ||.|....:.|...........:|.|
  Rat  1808 ARVFPYMEGDVSSKDKMGKGVDGTYKKALQEAA---ARFEELKAQKELRQLQEDRKNDKKPPPYK 1869

  Fly  3552 ----------IQVFVQPSDNELVPR---RGTGSNLPMAMKYRTL--------------------- 3582
                      :|:|.  :|...:||   :.|..| |..:....:
  Rat  1870 HIKVNRPIGRVQIFT--ADLSEIPRCNCKATDEN-PCGIDSECINRMLLYECHPTVCPAGGRCQN 1931

  Fly  3583 ----KETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGI-GCY 3642
                |..|.| |.:||:...|.||....||:.||.|.||.||||.......|.||.....| ..|
  Rat  1932 QCFSKRQYPD-VEIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFY 1995

  Fly  3643 MFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFP- 3706
            |..:|.:.::||..:||.|||:||||:|||.::...:.|...:.:|||..|..|.|||::|...
  Rat  1996 MLTLDKDRIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLEC 2060

  Fly  3707 FEDEKIPCSCGSKRCRKYL 3725
            ..:.|..|.||:..|..:|
  Rat  2061 LGNGKTVCKCGAPNCSGFL 2079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:413390
		PRK13914	<1006..>1224	CDD:237555
		PHD1_KMT2A_like	1268..1344	CDD:276981
		PHD	1346..1390	CDD:214584
		PHD3_KMT2A_like	1423..1479	CDD:276983
		ePHD_KMT2A_like	1737..1841	CDD:277134	12/103 (12%)
		FYRN	1890..1937	CDD:461787	11/57 (19%)
		FYRC	3388..3476	CDD:197781	17/93 (18%)
		SET_KMT2A_2B	3575..3726	CDD:380947	57/178 (32%)
Nsd1	NP_001388465.1	PWWP_NSD1_rpt1	318..433	CDD:438989	22/131 (17%)
		TNG2	<1452..1585	CDD:227367	26/146 (18%)
		PHD1_NSD1_2	1543..1585	CDD:277118	7/41 (17%)
		PHD2_NSD1	1590..1636	CDD:277120	7/45 (16%)
		PHD3_NSD1	1637..1690	CDD:277123	12/78 (15%)
		PHD4_NSD1	1707..1746	CDD:277126	7/38 (18%)
		PWWP_NSD1_rpt2	1753..1848	CDD:438992	11/97 (11%)
		AWS	1899..1937	CDD:465559	2/38 (5%)
		SET_NSD1	1939..2080	CDD:380987	56/142 (39%)
		PHD5_NSD1	2118..2160	CDD:277129
		C5HCH	2159..2208	CDD:465605
		PHA03247	<2221..2593	CDD:223021